Targeted Disruption of Myc –Max Oncoprotein Complex by a Small Molecule
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00799 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - October 11, 2017 Category: Chemistry Authors: Seung H. Choi, Madhupriya Mahankali, Sang Jun Lee, Mitchell Hull, H. Michael Petrassi, Arnab K. Chatterjee, Peter G. Schultz, Katherine A. Jones and Weijun Shen Source Type: research

Identifying Dysregulated Epigenetic Enzyme Activity in Castrate-Resistant Prostate Cancer Development
ACS Chemical BiologyDOI: 10.1021/acschembio.6b01035 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - October 11, 2017 Category: Chemistry Authors: Jin-Hee Lee, Bing Yang, Anastasia J. Lindahl, Nathan Damaschke, Melissa D. Boersma, Wei Huang, Eva Corey, David F. Jarrard and John M. Denu Source Type: research

Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00758 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - October 10, 2017 Category: Chemistry Authors: Vincent M. Alford, Anushree Kamath, Xiaodong Ren, Kunal Kumar, Qianwen Gan, Monaf Awwa, Michael Tong, Markus A. Seeliger, Jian Cao, Iwao Ojima and Nicole S. Sampson Source Type: research

Assaying RNA Localization in Situ with Spatially Restricted Nucleobase Oxidation
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00519 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - October 9, 2017 Category: Chemistry Authors: Ying Li, Mahima B. Aggarwal, Kim Nguyen, Ke Ke and Robert C. Spitale Source Type: research

Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00466 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - October 9, 2017 Category: Chemistry Authors: Priscila dos Santos Bury, Fanglu Huang, Sicong Li, Yuhui Sun, Peter F. Leadlay and Marcio Vinicius Bertacine Dias Source Type: research

Editing the Genome Without Double-Stranded DNA Breaks
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00710 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - October 9, 2017 Category: Chemistry Authors: Alexis C. Komor, Ahmed H. Badran and David R. Liu Source Type: research

Oligomerization State of CXCL4 Chemokines Regulates G Protein-Coupled Receptor Activation
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00704 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - October 4, 2017 Category: Chemistry Authors: Ya-Ping Chen, Hsin-Li Wu, Kevin Boye ́, Chen-Ya Pan, Yi-Chen Chen, Nadège Pujol, Chun-Wei Lin, Liang-Yuan Chiu, Clotilde Billottet, Isabel D. Alves, Andreas Bikfalvi and Shih-Che Sue Source Type: research

Observation by Real-Time NMR and Interpretation of Length- and Location-Dependent Deamination Activity of APOBEC3B
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00662 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - October 3, 2017 Category: Chemistry Authors: Li Wan, Takashi Nagata, Ryo Morishita, Akifumi Takaori-Kondo and Masato Katahira Source Type: research

Intertwined Precursor Supply during Biosynthesis of the Catecholate –Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00597 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - October 2, 2017 Category: Chemistry Authors: Jacob Gubbens, Changsheng Wu, Hua Zhu, Dmitri V. Filippov, Bogdan I. Florea, Se ́bastien Rigali, Herman S. Overkleeft and Gilles P. van Wezel Source Type: research

Two-Color 810 nm STED Nanoscopy of Living Cells with Endogenous SNAP-Tagged Fusion Proteins
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00616 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - October 2, 2017 Category: Chemistry Authors: Alexey N. Butkevich, Haisen Ta, Michael Ratz, Stefan Stoldt, Stefan Jakobs, Vladimir N. Belov and Stefan W. Hell Source Type: research

A Single-Chain Photoswitchable CRISPR-Cas9 Architecture for Light-Inducible Gene Editing and Transcription
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00603 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 29, 2017 Category: Chemistry Authors: Xin X. Zhou, Xinzhi Zou, Hokyung K. Chung, Yuchen Gao, Yanxia Liu, Lei S. Qi and Michael Z. Lin Source Type: research

Simultaneous Production of Anabaenopeptins and Namalides by the Cyanobacterium Nostoc sp. CENA543
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00570 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 29, 2017 Category: Chemistry Authors: Ta ̂nia K. Shishido, Jouni Jokela, David P. Fewer, Matti Wahlsten, Marli F. Fiore and Kaarina Sivonen Source Type: research

BAF180: Its Roles in DNA Repair and Consequences in Cancer
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00541 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 28, 2017 Category: Chemistry Authors: Sarah Hopson and Martin J. Thompson Source Type: research

Platinum Binds Proteins in the Endoplasmic Reticulum of S. cerevisiae and Induces Endoplasmic Reticulum Stress
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00553 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 28, 2017 Category: Chemistry Authors: Rachael M. Cunningham and Victoria J. DeRose Source Type: research

Discovery of Oligonucleotide Signaling Mediated by CRISPR-Associated Polymerases Solves Two Puzzles but Leaves an Enigma
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00713 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 27, 2017 Category: Chemistry Authors: Eugene V. Koonin and Kira S. Makarova Source Type: research

Backbone Circularization Coupled with Optimization of Connecting Segment in Effectively Improving the Stability of Granulocyte-Colony Stimulating Factor
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00776 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 27, 2017 Category: Chemistry Authors: Takamitsu Miyafusa, Risa Shibuya, Wataru Nishima, Rie Ohara, Chuya Yoshida and Shinya Honda Source Type: research

Inhibitors of the Diadenosine Tetraphosphate Phosphorylase Rv2613c of Mycobacterium tuberculosis
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00653 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 26, 2017 Category: Chemistry Authors: Kathrin H. Go ̈tz, Stephan M. Hacker, Daniel Mayer, Jan-Niklas Dürig, Steffen Stenger and Andreas Marx Source Type: research

Whole-Genome Shotgun Sequencing of Two β-Proteobacterial Species in Search of the Bulgecin Biosynthetic Cluster
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00687 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 26, 2017 Category: Chemistry Authors: Mark E. Horsman, Daniel R. Marous, Rongfeng Li, Ryan A. Oliver, Byungjin Byun, Scott J. Emrich, Bill Boggess, Craig A. Townsend and Shahriar Mobashery Source Type: research

Mapping the Binding Site for Escitalopram and Paroxetine in the Human Serotonin Transporter Using Genetically Encoded Photo-Cross-Linkers
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00338 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 26, 2017 Category: Chemistry Authors: Hafsteinn Rannversson, Jacob Andersen, Benny Bang-Andersen and Kristian Str ømgaard Source Type: research

Live Cell Imaging of Mitochondrial Autophagy with a Novel Fluorescent Small Molecule
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00647 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 21, 2017 Category: Chemistry Authors: Hidefumi Iwashita, Satoru Torii, Noriyoshi Nagahora, Munetaka Ishiyama, Kosei Shioji, Kazumi Sasamoto, Shigeomi Shimizu and Kentaro Okuma Source Type: research

CRISPR-Mediated Tagging of Endogenous Proteins with a Luminescent Peptide
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00549 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 21, 2017 Category: Chemistry Authors: Marie K. Schwinn, Thomas Machleidt, Kris Zimmerman, Christopher T. Eggers, Andrew S. Dixon, Robin Hurst, Mary P. Hall, Lance P. Encell, Brock F. Binkowski and Keith V. Wood Source Type: research

Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00581 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 20, 2017 Category: Chemistry Authors: Kenneth M. Lum, Yoshiaki Sato, Brittney A. Beyer, Warren C. Plaisted, Justin L. Anglin, Luke L. Lairson and Benjamin F. Cravatt Source Type: research

Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00484 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 19, 2017 Category: Chemistry Authors: Gert-Jan Moggre ́, Myles B. Poulin, Peter C. Tyler, Vern L. Schramm and Emily J. Parker Source Type: research

Structure-Guided Screening for Functionally Selective D2 Dopamine Receptor Ligands from a Virtual Chemical Library
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00493 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 19, 2017 Category: Chemistry Authors: Barbara Ma ̈nnel, Mariama Jaiteh, Alexey Zeifman, Alena Randakova, Dorothee Möller, Harald Hübner, Peter Gmeiner and Jens Carlsson Source Type: research

The Potency of Diarylamine Radical-Trapping Antioxidants as Inhibitors of Ferroptosis Underscores the Role of Autoxidation in the Mechanism of Cell Death
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00730 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 18, 2017 Category: Chemistry Authors: Ron Shah, Kaitlyn Margison and Derek A. Pratt Source Type: research

Bioactive Natural Products Prioritization Using Massive Multi-informational Molecular Networks
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00413 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 15, 2017 Category: Chemistry Authors: Florent Olivon, Pierre-Marie Allard, Alexey Koval, Davide Righi, Gregory Genta-Jouve, Johan Neyts, Ce ́cile Apel, Christophe Pannecouque, Louis-Félix Nothias, Xavier Cachet, Laurence Marcourt, Fanny Roussi, Vladimir L. Katanaev, David Touboul, Jean-Luc Source Type: research

Rheostatic Control of Cas9-Mediated DNA Double Strand Break (DSB) Generation and Genome Editing
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00652 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 15, 2017 Category: Chemistry Authors: John C. Rose, Jason J. Stephany, Cindy T. Wei, Douglas M. Fowler and Dustin J. Maly Source Type: research

An Anion −π Interaction Strongly Stabilizes the β-Sheet Protein WW
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00768 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 14, 2017 Category: Chemistry Authors: Mason S. Smith, Eliza E. K. Lawrence, Wendy M. Billings, Kimberlee S. Larsen, Natalie A. Be ́car and Joshua L. Price Source Type: research

BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00694 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 14, 2017 Category: Chemistry Authors: Mahboob Salim, Timothy J Knowles, Alfie T. Baker, Martin S. Davey, Mark Jeeves, Pooja Sridhar, John Wilkie, Carrie R. Willcox, Hachemi Kadri, Taher E. Taher, Pierre Vantourout, Adrian Hayday, Youcef Mehellou, Fiyaz Mohammed and Benjamin E. Willcox Source Type: research

Two Cooperative Glycosyltransferases Are Responsible for the Sugar Diversity of Saquayamycins Isolated from Streptomyces sp. KY 40-1
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00453 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 13, 2017 Category: Chemistry Authors: Shaimaa M. Salem, Stevi Weidenbach and Ju ̈rgen Rohr Source Type: research

Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00711 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 13, 2017 Category: Chemistry Authors: Kimberly E. Anderson, Milton To, James A. Olzmann and Daniel K. Nomura Source Type: research

Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00481 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 12, 2017 Category: Chemistry Authors: Julia C. Meier, Cynthia Tallant, Oleg Fedorov, Hanna Witwicka, Sung-Yong Hwang, Ruud G. van Stiphout, Jean-Philippe Lambert, Catherine Rogers, Clarence Yapp, Brian S. Gerstenberger, Vita Fedele, Pavel Savitsky, David Heidenreich, Danette L. Daniels, Dafyd Source Type: research

Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00617 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 12, 2017 Category: Chemistry Authors: Lars Dittus, Thilo Werner, Marcel Muelbaier and Marcus Bantscheff Source Type: research

Superhelicity Constrains a Localized and R-Loop-Dependent Formation of G-Quadruplexes at the Upstream Region of Transcription
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00435 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 11, 2017 Category: Chemistry Authors: Ke-wei Zheng, Yi-de He, Hong-he Liu, Xin-min Li, Yu-hua Hao and Zheng Tan Source Type: research

Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00479 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 8, 2017 Category: Chemistry Authors: Naga Sandhya Guntaka, Alan R. Healy, Jason M. Crawford, Seth B. Herzon and Steven D. Bruner Source Type: research

Functional Analysis of Cytochrome P450s Involved in Streptovaricin Biosynthesis and Generation of Anti-MRSA Analogues
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00467 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 7, 2017 Category: Chemistry Authors: Yuanzhen Liu, Xu Chen, Zhengyuan Li, Wei Xu, Weixin Tao, Jie Wu, Jian Yang, Zixin Deng and Yuhui Sun Source Type: research

Exploiting Overlapping Advantages of In Vitro and In Cellulo Selection Systems to Isolate a Novel High-Affinity cJun Antagonist
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00693 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 7, 2017 Category: Chemistry Authors: Daniel Baxter, Christopher G. Ullman, Laura Frigotto and Jody M. Mason Source Type: research

Ionic Strength Sensing in Living Cells
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00348 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 6, 2017 Category: Chemistry Authors: Boqun Liu, Bert Poolman and Arnold J. Boersma Source Type: research

BNANC Gapmers Revert Splicing and Reduce RNA Foci with Low Toxicity in Myotonic Dystrophy Cells
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00416 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 5, 2017 Category: Chemistry Authors: Kassie S. Manning, Ashish N. Rao, Miguel Castro and Thomas A. Cooper Source Type: research

Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00485 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 5, 2017 Category: Chemistry Authors: Philipp Ottis, Momar Toure, Philipp M. Cromm, Eunhwa Ko, Jeffrey L. Gustafson and Craig M. Crews Source Type: research

Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00589 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 1, 2017 Category: Chemistry Authors: Sebastian Go ̈tze, Regine Herbst-Irmer, Martin Klapper, Helmar Görls, Kilian R. A. Schneider, Robert Barnett, Thomas Burks, Ursula Neu and Pierre Stallforth Source Type: research

Enhancing the Potency of Nalidixic Acid toward a Bacterial DNA Gyrase with Conjugated Peptides
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00540 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 1, 2017 Category: Chemistry Authors: Marya Ahmed and Shana O. Kelley Source Type: research

Synthetic Lethality Triggered by Combining Olaparib with BRCA2 –Rad51 Disruptors
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00707 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - September 1, 2017 Category: Chemistry Authors: Federico Falchi, Elisa Giacomini, Tiziana Masini, Nicolas Boutard, Lorenza Di Ianni, Marcella Manerba, Fulvia Farabegoli, Lara Rossini, Janet Robertson, Saverio Minucci, Isabella Pallavicini, Giuseppina Di Stefano, Marinella Roberti, Roberto Pellicciari a Source Type: research

Chemical Interrogation of LuxR-type Quorum Sensing Receptors Reveals New Insights into Receptor Selectivity and the Potential for Interspecies Bacterial Signaling
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00458 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - August 31, 2017 Category: Chemistry Authors: Joseph P. Gerdt, Danielle M. Wittenwyler, Joshua B. Combs, Michelle E. Boursier, Jacob W. Brummond, He Xu and Helen E. Blackwell Source Type: research

Elucidating Substrate Promiscuity within the FabI Enzyme Family
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00400 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - August 31, 2017 Category: Chemistry Authors: Gabriel S. Freund, Terrence E. O ’Brien, Logan Vinson, Dylan Alexander Carlin, Andrew Yao, Wai Shun Mak, Ilias Tagkopoulos, Marc T. Facciotti, Dean J. Tantillo and Justin B. Siegel Source Type: research

Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00330 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - August 30, 2017 Category: Chemistry Authors: Nicholas J. Porter and David W. Christianson Source Type: research

Chemically Sumoylated Histone H4 Stimulates Intranucleosomal Demethylation by the LSD1 –CoREST Complex
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00716 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - August 30, 2017 Category: Chemistry Authors: Abhinav Dhall, Caroline E. Weller, Aurea Chu, Patrick M. M. Shelton and Champak Chatterjee Source Type: research

Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00468 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - August 29, 2017 Category: Chemistry Authors: John P. Santa Maria, Yumi Park, Lihu Yang, Nicholas Murgolo, Michael D. Altman, Paul Zuck, Greg Adam, Chad Chamberlin, Peter Saradjian, Peter Dandliker, Helena I. M. Boshoff, Clifton E. Barry, Charles Garlisi, David B. Olsen, Katherine Young, Meir Glick, Source Type: research

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00527 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - August 29, 2017 Category: Chemistry Authors: Jamie R. Genthe, Jaeki Min, Dana M. Farmer, Anang A. Shelat, Jose A. Grenet, Wenwei Lin, David Finkelstein, Karen Vrijens, Taosheng Chen, R. Kiplin Guy, Wilson K. Clements and Martine F. Roussel Source Type: research

8-Oxo-7,8-dihydroguanine in the Context of a Gene Promoter G-Quadruplex Is an On –Off Switch for Transcription
ACS Chemical BiologyDOI: 10.1021/acschembio.7b00636 (Source: ACS Chemical Biology)
Source: ACS Chemical Biology - August 28, 2017 Category: Chemistry Authors: Aaron M. Fleming, Judy Zhu, Yun Ding and Cynthia J. Burrows Source Type: research