IIG seminar “ Myeloid-derived IL-33 intersects with neuronal immunity ”
This seminar will be given by Dr. Herbert who has made important contributions towards understanding mechanisms controlling development of alternatively activated macrophages and Type 2 inflammation within the respiratory and gastrointestinal tract. His recent findings reveal a previously undescribed mechanism of intercellular cross-talk wherein “ itch ” neuron activation reshapes myeloid cytokine expression patterns to alter skin composition for cutaneous immunity against invasive pathogens.Air date: 5/15/2024 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - April 16, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Sensing Inflammation in the Skin and Beyond
The type 2 immune response has evolved to arm the mammalian host with the capacity to expel parasites and noxious environmental substances from barrier surfaces. One critical aspect of this defense mechanism is stimulating protective behavioral responses such as coughing, sneezing, and scratching. Increasingly, it is appreciated that cytokines associated with type 2 immunity such as IL-4, IL-13, and IL-31 play critical roles in triggering mechanical reflexes like itch via direct interactions with sensory neurons. However, the tissue- and cell-specific manner in which these cytokines imprint unique sensory and neuroinflamma...
Source: Videocast - All Events - November 22, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Cell transplants to treat the “disease” of chronic pain
NIH Director's Wednesday Afternoon Lecture Series
Neuropathic pain arises, in part, from a nerve injury-induced loss of spinal cord GABAergic inhibitory controls. Here we asked whether the neurological consequences of peripheral nerve damage can be overcome by transplanting embryonic cortical GABAergic precursor cells into the spinal cord. Using electrophysiological, neuroanatomical and behavioral approaches, we found that the cells integrate into host spinal cord circuits and can ameliorate the persistent pain and itch associated with nerve damage.For more information go to https://oir.nih.gov/walsAir date: 5/18/2016 3:0...
Source: Videocast - All Events - April 19, 2016 Category: Journals (General) Tags: Upcoming Events Source Type: video
Scratching beneath the surface of itch, touch and pain
Presented by: Diana Bautista, Ph.D., University of California, BerkeleyCategory: NIH OnlyAired date: 10/27/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - October 27, 2014 Category: Journals (General) Tags: Past Events Source Type: video
Scratching beneath the surface of itch, touch and pain
Neuroscience Seminar SeriesAir date: 10/27/2014 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 7, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
