Fibronectin promotes wound healing in an atopic human skin xenografting model
Atopic dermatitis (AD) is a chronic, inflammatory skin disease characterized by dry and itchy lesions that can be localized or extend over large portions of the body. Skin lesions in AD patients have increased expression of Th2 cytokines, and IL-4 promotes the pathogenesis of AD and skin fibrotic remodeling. Human skin biopsies and primary keratinocytes stimulated with IL-4 demonstrate diminished epidermal differentiation complex (EDC) gene expression (Howell et al., 2007). Our previous reports have shown that mutations of EDC genes and increased Th2 responses cooperate to exacerbate diminished barrier function in the Stat...
Source: Journal of Investigative Dermatology - November 30, 2023 Category: Dermatology Authors: Wenwu Zhang, Nahid Akhtar, Jennifer Zhao, Dan F. Spandau, Mark H. Kaplan Tags: Letters to the Editor Source Type: research
Strategies for coping with stress in mothers of children with atopic dermatitis - a cross-sectional study
CONCLUSIONS: Although mothers of children with AD experience higher levels of stress compared with mothers of children without AD, the disease does not change coping strategies. Psychological support for mothers of children with AD should be oriented toward strengthening cognitive coping strategies.PMID:38028406 | PMC:PMC10646713 | DOI:10.5114/ada.2023.127934 (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 29, 2023 Category: Dermatology Authors: Aleksandra K Kobusiewicz Bart łomiej Tarkowski Andrzej Kaszuba Anna Zalewska-Janowska Source Type: research
Association of pruritus with sleep in patients with psoriasis and chronic spontaneous urticaria: A cross-sectional study
CONCLUSION: Nocturnal itch is prevalent in chronic dermatoses and significant for sleep deficit and impaired QoL. Early screening and management of sleep disturbance among patients presenting with nocturnal itch should be routinely undertaken.PMID:38024914 | PMC:PMC10657069 | DOI:10.4103/jfmpc.jfmpc_2425_22 (Source: Primary Care)
Source: Primary Care - November 29, 2023 Category: Primary Care Authors: Prakriti Shukla Parul Verma Srishti Tripathi Alok K Dwivedi Mukesh Shukla Swastika Suvirya Source Type: research
Discussion on the Antipruritic Mechanism of Qiwei Antipruritic Based on Network Pharmacology and Molecular Docking Technology
CONCLUSION: The mechanism of Qiwei antipruritic may be related to histamine activation mechanism, calcium channel mechanism, inhibition of inflammatory signaling pathway, inhibition of neurotransmitters, and regulation of immune pathways. The traditional Chinese medicine compound Qiwei antipruritic can treat clinical pruritus through multiple targets and pathways.PMID:38021433 | PMC:PMC10657760 | DOI:10.2147/CCID.S435800 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - November 29, 2023 Category: Dermatology Authors: Luoxi Wang Tinghan Deng Ying Liu Hongbin Cheng Source Type: research
Strategies for coping with stress in mothers of children with atopic dermatitis - a cross-sectional study
CONCLUSIONS: Although mothers of children with AD experience higher levels of stress compared with mothers of children without AD, the disease does not change coping strategies. Psychological support for mothers of children with AD should be oriented toward strengthening cognitive coping strategies.PMID:38028406 | PMC:PMC10646713 | DOI:10.5114/ada.2023.127934 (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - November 29, 2023 Category: Dermatology Authors: Aleksandra K Kobusiewicz Bart łomiej Tarkowski Andrzej Kaszuba Anna Zalewska-Janowska Source Type: research
A recalcitrant skin lesion and subsequent infection in a recreational intramural male athlete: a case report
J Athl Train. 2023 Nov 28. doi: 10.4085/1062-6050-0467.22. Online ahead of print.ABSTRACTA 35-year-old intramural male athlete presented to the athletic training staff with a 4.5cm x 2.2cm itchy, painful, swollen, and infected insidious skin lesion on his right lateral malleolus due to an underlying dermatological deficiency. Suspecting infection, the patient was referred to his nurse practitioner and was diagnosed with atopic dermatitis caused by a ceramide deficiency. He was placed on Cefalexin and Mupirocin 2% ointment but returned due to the lesion increasing to 8.5cm x 6cm although infection seemed controlled. He was ...
Source: Journal of Athletic Training - November 28, 2023 Category: Sports Medicine Authors: James E Leone Kimberly A Gray Source Type: research
A recalcitrant skin lesion and subsequent infection in a recreational intramural male athlete: a case report
J Athl Train. 2023 Nov 28. doi: 10.4085/1062-6050-0467.22. Online ahead of print.ABSTRACTA 35-year-old intramural male athlete presented to the athletic training staff with a 4.5cm x 2.2cm itchy, painful, swollen, and infected insidious skin lesion on his right lateral malleolus due to an underlying dermatological deficiency. Suspecting infection, the patient was referred to his nurse practitioner and was diagnosed with atopic dermatitis caused by a ceramide deficiency. He was placed on Cefalexin and Mupirocin 2% ointment but returned due to the lesion increasing to 8.5cm x 6cm although infection seemed controlled. He was ...
Source: J Athl Train - November 28, 2023 Category: Sports Medicine Authors: James E Leone Kimberly A Gray Source Type: research
A recalcitrant skin lesion and subsequent infection in a recreational intramural male athlete: a case report
J Athl Train. 2023 Nov 28. doi: 10.4085/1062-6050-0467.22. Online ahead of print.ABSTRACTA 35-year-old intramural male athlete presented to the athletic training staff with a 4.5cm x 2.2cm itchy, painful, swollen, and infected insidious skin lesion on his right lateral malleolus due to an underlying dermatological deficiency. Suspecting infection, the patient was referred to his nurse practitioner and was diagnosed with atopic dermatitis caused by a ceramide deficiency. He was placed on Cefalexin and Mupirocin 2% ointment but returned due to the lesion increasing to 8.5cm x 6cm although infection seemed controlled. He was ...
Source: Journal of Athletic Training - November 28, 2023 Category: Sports Medicine Authors: James E Leone Kimberly A Gray Source Type: research
A recalcitrant skin lesion and subsequent infection in a recreational intramural male athlete: a case report
J Athl Train. 2023 Nov 28. doi: 10.4085/1062-6050-0467.22. Online ahead of print.ABSTRACTA 35-year-old intramural male athlete presented to the athletic training staff with a 4.5cm x 2.2cm itchy, painful, swollen, and infected insidious skin lesion on his right lateral malleolus due to an underlying dermatological deficiency. Suspecting infection, the patient was referred to his nurse practitioner and was diagnosed with atopic dermatitis caused by a ceramide deficiency. He was placed on Cefalexin and Mupirocin 2% ointment but returned due to the lesion increasing to 8.5cm x 6cm although infection seemed controlled. He was ...
Source: J Athl Train - November 28, 2023 Category: Sports Medicine Authors: James E Leone Kimberly A Gray Source Type: research
A recalcitrant skin lesion and subsequent infection in a recreational intramural male athlete: a case report
J Athl Train. 2023 Nov 28. doi: 10.4085/1062-6050-0467.22. Online ahead of print.ABSTRACTA 35-year-old intramural male athlete presented to the athletic training staff with a 4.5cm x 2.2cm itchy, painful, swollen, and infected insidious skin lesion on his right lateral malleolus due to an underlying dermatological deficiency. Suspecting infection, the patient was referred to his nurse practitioner and was diagnosed with atopic dermatitis caused by a ceramide deficiency. He was placed on Cefalexin and Mupirocin 2% ointment but returned due to the lesion increasing to 8.5cm x 6cm although infection seemed controlled. He was ...
Source: Journal of Athletic Training - November 28, 2023 Category: Sports Medicine Authors: James E Leone Kimberly A Gray Source Type: research
Imiquimod-induced pruritus in female wild-type and knockin Wistar rats: underscoring behavioral scratching in a rat model for antipruritic treatments
Animal models of skin disease are used to evaluate therapeutics to alleviate disease. One common clinical dermatological complaint is pruritus (itch), but there is a lack of standardization in the characteriza... (Source: BMC Research Notes)
Source: BMC Research Notes - November 25, 2023 Category: Research Authors: Karen Lariosa-Willingham, Dmitri Leonoudakis, Florian Simon, Kendall Walker, Philippe Guillaume, Liling Warren and Jennifer Stratton Tags: Research Note Source Type: research
Evaluation and Management of Pruritus and Scabies in the Elderly Population
Pruritus is the most common dermatologic complaint in the geriatric population. Its growing prevalence coincides with the rapid growth of the elderly population (>65 years of age) in the United States. According to the US Census Bureau, 16.9% of the population, or more than 56 million adults 65 years and older, lived in the United States in 2022. Pruritus is a condition that accompanies a diverse array of underlying etiologic factors. The mechanism of normal i tch impulse transmission has been recently elucidated. The itch sensation originates from epidermal/dermal receptors connected to unmyelinated, afferent C-fibers t...
Source: Clinics in Geriatric Medicine - November 23, 2023 Category: Geriatrics Authors: Shakira Meltan, Bharat Panuganti, Michelle Tarbox Source Type: research
That itchy, scratchy feeling strikes when Staph bacteria get to work
Nature, Published online: 22 November 2023; doi:10.1038/d41586-023-03561-xAn enzyme wielded by a common skin bacterium acts on nerve receptors that trigger intense itching. (Source: Nature AOP)
Source: Nature AOP - November 22, 2023 Category: Research Source Type: research
IL-33 Potentiates Histaminergic Itch
(Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Anna M. Trier, Aaron Ver Heul, Avery Fredman, Victoria Le, Zhen Wang, Kelsey Auyeung, James Meixiong, Paola Lovato, Michael J. Holtzman, Fang Wang, Xinzhong Dong, Andrew L. Ji, Brian S. Kim Source Type: research
Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching
ConclusionThese results suggest that OSM is an important cytokine in the regulation of skin monocytes, promoting the actions of IL-4 and IL-13 in the DRG and suppressing the action of IL-31. It is speculated that OSM released from monocytes in skin modulates the sensitivity of DRG neurons to type 2 inflammatory cytokines and thereby the severity of AD-associated skin itch. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - November 16, 2023 Category: Allergy & Immunology Source Type: research
