Molecular Dynamics Simulation and NMR Investigation of the Association of the β-Blockers Atenolol and Propranolol with a Chiral Molecular Micelle.
This study is part of a larger effort to understand the mechanism of chiral recognition in capillary electrophoresis by characterizing the molecular micelle binding of chiral compounds with different geometries and charges. Propranolol and atenolol were chosen because their structures are similar, but their chiral interactions with the molecular micelle are different. Molecular dynamics simulations showed both propranolol enantiomers inserted their aromatic rings into the molecular micelle core and that (S)-propranolol associated more strongly with the molecular micelle than (R)-propranolol. This difference was attributed ...
Source: Chemical Physics - August 13, 2015 Category: Chemistry Authors: Morris KF, Billiot EJ, Billiot FH, Hoffman CB, Gladis AA, Lipkowitz KB, Southerland WM, Fang Y Tags: Chem Phys Source Type: news
How Common Are Tremors in Childhood?
Discussion
Tremor is one of several movement disorders in childhood including tics, dystonia, chorea, myoclonus, and sterotypy. Tremors are a rhythmic oscillating involuntary movement across a joint axis. They are the result of normal or accentuated postural or muscular processes. They are categorized as follows:
Rest tremor – occurs during rest and stops with movement
Action tremor- occurs during a voluntary activity
Kinetic tremor- occurs when limb is moving
Postural tremor – occurs when the limb is stationary but held against gravity
Isometric tremor – occurs when limb is stationary but is exerting a...
Source: PediatricEducation.org - May 11, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Heart Drug Clears Up 'Strawberry' Birthmarks
Study suggests propranolol as a new option to treat infantile hemangioma (Source: WebMD Health)
Source: WebMD Health - February 19, 2015 Category: Consumer Health News Source Type: news
Oral Propranolol Successfully Treats Infantile Hemangioma (FREE)
By Mary Wu Chang, MD
Propranolol is successful and safe in treating infantile hemangioma (IH), but optimal dosing remains to be established, according to an industry-funded study in … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - February 19, 2015 Category: Primary Care Source Type: news
Heart Drug Clears Up 'Strawberry' Birthmarks
Study suggests propranolol as a new option to treat infantile hemangioma
Source: HealthDay
Related MedlinePlus Pages: Birthmarks, Blood Pressure Medicines, Uncommon Infant and Newborn Problems (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - February 18, 2015 Category: Consumer Health News Source Type: news
Infantile Hemangioma, Propranolol, and CNS FunctionInfantile Hemangioma, Propranolol, and CNS Function
Recent studies have suggested that propranolol use is associated with CNS effects including memory problems, sleep disturbance, and psychomotor function. Is it safe to use in infantile hemangioma? The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 16, 2015 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news
Propranolol for Infantile Haemangiomas: Chances and RisksPropranolol for Infantile Haemangiomas: Chances and Risks
Propranolol has become the first-line therapy for complicated hemangiomas, but new studies have raised questions about its safety. The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 9, 2015 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news
Update on Propranolol for Infantile Hemangioma: Where Are We Now?
The discovery of propranolol for the treatment of infantile hemangioma in 2008 has revolutionized management of this condition. Hundreds of reports have corroborated the initial published findings that propranolol is a safe and efficacious therapeutic agent. Furthermore, it is well tolerated in infants and can markedly alter the natural history and potential disfigurement of these lesions. The goal of this review is to outline the salient features of infantile hemangioma and the optimal use of propranolol as a first-line treatment modality. (Source: NeoReviews recent issues)
Source: NeoReviews recent issues - January 1, 2015 Category: Pediatrics Authors: Cyrulnik, A. A., Glick, S. A. Tags: Pediatric Drug Labeling Update Articles Source Type: news
Propranolol in infantile hemangioma: Indication of major added benefit in some patients
Data were only available for children at risk of permanent scars or disfigurement, however, based on this information, scientists report that added benefit of propranolol in infantile hemangioma is proven in other children with proliferating hemangioma. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 5, 2014 Category: Science Source Type: news
Propranolol in infantile hemangioma: Indication of major added benefit in some patients
(Institute for Quality and Efficiency in Health Care) Data were only available for children at risk of permanent scars or disfigurement. No added benefit is proven in other children with proliferating hemangioma. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 5, 2014 Category: Global & Universal Source Type: news
Beta-blockers expand treatment options for infantile hemangiomas
VANCOUVER, B.C. – Propranolol may have revolutionized the treatment of infantile hemangiomas over the past decade, but other beta-blockers are making inroads in the treatment of these and other pediatric dermatologic disorders.
One such beta-blocker is atenolol, a hydrophilic cardioselective agent...googletag.display('div-gpt-ad-cta'); (Source: Skin and Allergy News)
Source: Skin and Allergy News - November 18, 2014 Category: Dermatology Tags: PED News PED Dermatology SAN Expert Analysis SAN Clinical News SAN News SAN Lasers and Treatment Modalities SAN Pediatric Dermatology Source Type: news
Could meditation help combat migraines?
ConclusionThis pilot RCT, based on just 19 adult migraine sufferers, showed an eight-week mindfulness-based stress reduction course led to benefits for headache duration, disability, self-efficacy and mindfulness measures, compared to a control group who received usual care. There were non-significant benefits observed for measures of migraine frequency and severity. Both groups continued to take any migraine medication (prophylactic or for treatment during a headache) they were already taking before the trial.The research group themselves were very reasonable in their conclusions and called for larger trials to be done t...
Source: NHS News Feed - September 15, 2014 Category: Consumer Health News Tags: Medical practice Neurology Mental health Source Type: news
European Commission approves Pierre Fabre’s Hemangiol for infantile hemangioma treatment
Pierre Fabre Dermatologie Laboratories has received paediatric use marketing authorisation from the European Commission for Hemangiol (propranolol), indicated for the treatment of proliferating infantile hemangioma. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - May 5, 2014 Category: Pharmaceuticals Source Type: news
Hemangeol (Propranolol Hydrochloride Oral Solution) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - April 3, 2014 Category: Drugs & Pharmacology Source Type: news
Beta Blocker May Ease Social Problems in AutismBeta Blocker May Ease Social Problems in Autism
Preliminary research suggests the beta blocker propranolol may help teens and young adults with autism improve their social interaction and problem- solving skills. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 19, 2014 Category: Consumer Health News Tags: Psychiatry News Source Type: news
