Timing of Radiotherapy (RT) After Radical Prostatectomy (RP): Long-term outcomes in the RADICALS-RT trial [NCT00541047]
Ann Oncol. 2024 Apr 5:S0923-7534(24)00105-4. doi: 10.1016/j.annonc.2024.03.010. Online ahead of print.ABSTRACTBACKGROUND: The optimal timing of radiotherapy (RT) after radical prostatectomy for prostate cancer has been uncertain. RADICALS-RT compared efficacy and safety of adjuvant RT versus an observation policy with salvage RT for PSA failure.METHODS: RADICALS-RT was a randomised controlled trial enrolling patients with ≥1 risk factor (pT3/4, Gleason 7-10, positive margins, pre-op PSA≥10ng/ml) for recurrence after radical prostatectomy. Patients were randomised 1:1 to adjuvant RT ("Adjuvant-RT") or an observation pol...
Source: Cancer Control - April 7, 2024 Category: Cancer & Oncology Authors: C C Parker P M Petersen A D Cook N W Clarke C Catton W R Cross H Kynaston W R Parulekar R A Persad F Saad L Bower G C Durkan J Logue C Maniatis D Noor H Payne J Anderson A K Bahl F Bashir D M Bottomley K Brasso L Capaldi P W Cooke C Chung J Donohue B Eddy Source Type: research
Timing of Radiotherapy (RT) After Radical Prostatectomy (RP): Long-term outcomes in the RADICALS-RT trial [NCT00541047]
Ann Oncol. 2024 Apr 5:S0923-7534(24)00105-4. doi: 10.1016/j.annonc.2024.03.010. Online ahead of print.ABSTRACTBACKGROUND: The optimal timing of radiotherapy (RT) after radical prostatectomy for prostate cancer has been uncertain. RADICALS-RT compared efficacy and safety of adjuvant RT versus an observation policy with salvage RT for PSA failure.METHODS: RADICALS-RT was a randomised controlled trial enrolling patients with ≥1 risk factor (pT3/4, Gleason 7-10, positive margins, pre-op PSA≥10ng/ml) for recurrence after radical prostatectomy. Patients were randomised 1:1 to adjuvant RT ("Adjuvant-RT") or an observation pol...
Source: Ann Oncol - April 7, 2024 Category: Cancer & Oncology Authors: C C Parker P M Petersen A D Cook N W Clarke C Catton W R Cross H Kynaston W R Parulekar R A Persad F Saad L Bower G C Durkan J Logue C Maniatis D Noor H Payne J Anderson A K Bahl F Bashir D M Bottomley K Brasso L Capaldi P W Cooke C Chung J Donohue B Eddy Source Type: research
Timing of Radiotherapy (RT) After Radical Prostatectomy (RP): Long-term outcomes in the RADICALS-RT trial [NCT00541047]
Ann Oncol. 2024 Apr 5:S0923-7534(24)00105-4. doi: 10.1016/j.annonc.2024.03.010. Online ahead of print.ABSTRACTBACKGROUND: The optimal timing of radiotherapy (RT) after radical prostatectomy for prostate cancer has been uncertain. RADICALS-RT compared efficacy and safety of adjuvant RT versus an observation policy with salvage RT for PSA failure.METHODS: RADICALS-RT was a randomised controlled trial enrolling patients with ≥1 risk factor (pT3/4, Gleason 7-10, positive margins, pre-op PSA≥10ng/ml) for recurrence after radical prostatectomy. Patients were randomised 1:1 to adjuvant RT ("Adjuvant-RT") or an observation pol...
Source: Ann Oncol - April 7, 2024 Category: Cancer & Oncology Authors: C C Parker P M Petersen A D Cook N W Clarke C Catton W R Cross H Kynaston W R Parulekar R A Persad F Saad L Bower G C Durkan J Logue C Maniatis D Noor H Payne J Anderson A K Bahl F Bashir D M Bottomley K Brasso L Capaldi P W Cooke C Chung J Donohue B Eddy Source Type: research
