Best dose fractionation to try to induce Abscopal in NSCLC?
Hello dear friends,
I have a 60 yo patient, very fit that was diagnosed of a left NSCLC, that was resected and received adjuvant RT for N2 disease.
She did very well.
2 years later she developed 4 small nodules in the right Lung (controlateral) as only site for disease progression.
Biopsy revealed NCSLC , PDL-1+>90%.
She received a Immunotherapy. at the follow-up, the number of lesions increased to 7 nodules. 2 out of 7 increased in size - with one adherent to the chestwall and that may...
Best dose fractionation to try to induce Abscopal in NSCLC? (Source: Student Doctor Network)
Source: Student Doctor Network - March 7, 2020 Category: Universities & Medical Training Authors: Kroll2013 Tags: Radiation Oncology Source Type: forums
Question about Head and Neck Cancers and Immunotherapy
In my cancer immunology class, we discussed immunotherapies for various head and neck cancers. We had a surgical oncologist come in and talk about his work as well. What I'm curious about is, how will immunotherapies affect surgical treatment of H&N cancers? Will it render surgical intervention obsolete or will it help surgeons more easily resect the tumors? (Source: Student Doctor Network)
Source: Student Doctor Network - November 20, 2019 Category: Universities & Medical Training Authors: Alakazam123 Tags: Medical Students - MD Source Type: forums
ASTRO to CMS: "By the love of all that's holy, PLEASE delay rolling out the APM!"
https://www.journalofclinicalpathways.com/news/astro-congress-urge-cms-adjust-radiation-oncology-apm
Final decision expected soon. We are all waiting with bated breath. Have to say I agree with ASTRO on this one - most programs need at least one year (1/2021) to implement appropriate infrastructure to meet mandates of RO APM.
Then again, Azar does need to make some cuts ASAP to account for all the immunotherapy/CAR-T products in the pipeline for 2020 . . . (Source: Student Doctor Network)
Source: Student Doctor Network - November 16, 2019 Category: Universities & Medical Training Authors: Gfunk6 Tags: Radiation Oncology Source Type: forums
Reflexion - BgRT
I heard a presentation yesterday from Reflexion - they have built an integrated Tomotherapy + PET unit to perform what they call "biologically-directed therapy" or BgRT. I am happy to answer questions about it on this thread.
Two things which stood out from the presentation is that the entire concept of BgRT is predicated on two large assumptions (supported by preliminary research but not validated in large trials):
1. SRS/SBRT + Immunotherapy = abscopal effect = better patient endpoints...
Reflexion - BgRT (Source: Student Doctor Network)
Source: Student Doctor Network - October 31, 2019 Category: Universities & Medical Training Authors: Gfunk6 Tags: Radiation Oncology Source Type: forums
Vaccine against cancer: a progressive solution.
The proposal of vaccines against cancer is presented in three stages, the first stage covers the research published by Moshe Reuven et al in the American Chemical Society in which a immunotherapy prevention is created, that, by using antigens and glyconanoparticles created by a biomimetic process, produce more immune cells and get them to easily identify the canker cells in the body and then destroy them. (Moshe et al, 2019).
The second stage applies to those who are suffering...
Vaccine against cancer: a progressive solution. (Source: Student Doctor Network)
Source: Student Doctor Network - October 26, 2019 Category: Universities & Medical Training Authors: Jorge Genis Tags: Student Research and Publishing Source Type: forums
Question about Surgical Oncologists (because of a class event)
We had a Surgical Oncologist come into our class, and talk about what he does for a living. The class was on Cancer Immunology, and he talked about how he was working on immunotherapy for rectal cancer. He told us that in the past rectal cancer patients often were inoperable and were poor candidates for surgery, but that with advances, things have considerably improved.
I'm curious about the following. With the success of immunotherapy, will a lot of surgical oncological procedures become...
Question about Surgical Oncologists (because of a class event) (Source: Student Doctor Network)
Source: Student Doctor Network - July 7, 2019 Category: Universities & Medical Training Authors: Alakazam123 Tags: Pre-Medical - MD Source Type: forums
Advice on journal to submit to
Hello everyone. I'm looking for advice on where I could submit this research project I did during medical school.
Basically it's a broad historical overview of the history of cancer immunotherapy, from 1880's to modern day with some analysis and projections into the future. I have submitted it to 3 journals so far which all said something along the lines of "this is good and interesting to read, but is not within the scope of our journal. We only accept journals answering a specific...
Advice on journal to submit to (Source: Student Doctor Network)
Source: Student Doctor Network - June 11, 2019 Category: Universities & Medical Training Authors: NTheo91 Tags: Medical Students - MD Source Type: forums
Re: Combination immunotherapy: the emerging treatment that removes cancer ’s “cloak of invisibility”
(Source: BMJ Comments)
Source: BMJ Comments - June 10, 2019 Category: General Medicine Source Type: forums
Future of Rad Onc with therapy advances
I'm interested in pursuing Radiation Oncology, and was hoping to hear some thoughts on what the future will be like for Radiation Oncologists with some of the advancements in cancer therapy coming out (immunotherapy, for example). From my naive perspective, it seems like the future is pretty uncertain. (Source: Student Doctor Network)
Source: Student Doctor Network - April 18, 2018 Category: Universities & Medical Training Authors: premed1234567891011 Source Type: forums
Is Immunotherapy only the purview of Med Onc?
M4 here, currently pursuing a path in Radiation Oncology. I have always been keenly interested in cancer since I started medical school, and was drawn specifically to Rad Onc due to its use of technology, treatment success, academic nature, and comprehensive range of malignancies one is able to see in this field. However, there were certainly aspects of Medical Oncology that I was attracted to as well; having a little more "ownership" of the patient being one, and the exciting new...
Is Immunotherapy only the purview of Med Onc? (Source: Student Doctor Network)
Source: Student Doctor Network - June 5, 2017 Category: Universities & Medical Training Authors: fw5tape6kq Source Type: forums
Radiation & Immunotherapy Clinical Evidence
Published online today Lancet Oncology:
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(17)30380-7/fulltext
Progression-free survival with pembrolizumab was significantly longer in patients who previously received extracranial radiotherapy compared with those without previous extracranial radiotherapy (HR 0·50 [0·30–0·84], p=0·0084; median progression-free survival 6·3 months [95% CI 2·1–10·4] vs 2·0 months [1·8–2·1]). Overall survival with pembrolizumab...
Radiation & Immunotherapy Clinical Evidence (Source: Student Doctor Network)
Source: Student Doctor Network - May 27, 2017 Category: Universities & Medical Training Authors: Xrt4life Source Type: forums
Can I sue Paracosm because immunotherapy is not available on the NHS?
Forum: Chat
Posted By: Inappropriately
Post Time: 06-03-2017 at 02:00 (Source: The Student Room)
Source: The Student Room - March 6, 2017 Category: Universities & Medical Training Source Type: forums
MS Bio...will it help??
Will a MS in Bio help me? Or will it raise some questions? My LONG TERM goal is to become a pediatric oncologist. The program that I had been accepted to will allow my research to be focused on immunotherapy. (Source: Student Doctor Network)
Source: Student Doctor Network - February 20, 2017 Category: Universities & Medical Training Authors: MountainClimber94 Source Type: forums
SRS Brain for Melanoma on Nivolumab and Ipilimumab?
Anyone doing this? Lit search shows promise of SRS with immunotherapy but I don't see a whole lot of safety in humans type data. (Source: Student Doctor Network)
Source: Student Doctor Network - February 19, 2017 Category: Universities & Medical Training Authors: Mandelin Rain Source Type: forums
2.66cGPA - 2.54sGPA - 521 MCAT
My GPA (2.66) sucks and my MCAT (c/s 130 - CARS 131 - b/b 130 - p/s 130 - Total 521) score is great...what can I do???
I have tons of volunteer experience (Clinical + Non-clinical), 300+ hours shadowing (MD + DO), a few publications (Trauma, Immunotherapy, Public Health), and have done NK Cell Immunotherapy research for the past 18 months. Currently working as the Biology Lab Coordinator for a university and as a research for UCSF Peds Residency program. Recently, I developed 2 programs...
2.66cGPA - 2.54sGPA - 521 MCAT (Source: Student Doctor Network)
Source: Student Doctor Network - August 22, 2016 Category: Universities & Medical Training Authors: mms9 Source Type: forums
