Fight Aging! Newsletter, December 25th 2023
This study generates a comprehensive single-cell transcriptomic atlas of human atherosclerosis including 118,578 high-quality cells from atherosclerotic coronary and carotid arteries. By performing systematic benchmarking of integration methods, we mitigated data overcorrection while separating major cell lineages. Notably, we define cell subtypes that have not been previously identified from individual human atherosclerosis scRNA-seq studies.
Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome...
Source: Fight Aging! - December 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Nectandrin B Extends Life in Flies
In this study, we present evidence that Nectandrin B (NecB), a bioactive lignan compound isolated from nutmeg, significantly extended the lifespan of the fruit fly Drosophila melanogaster by as much as 42.6% compared to the control group. NecB also improved age-related symptoms including locomotive deterioration, body weight gain, eye degeneration, and neurodegeneration in aging D. melanogaster. This result represents the most substantial improvement in lifespan observed in animal experiments to date, suggesting that NecB may hold promise as a potential therapeutic agent for promoting longevity and addressing age-related d...
Source: Fight Aging! - December 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
5 Foods Science Says Will Help You Live Longer
The foods that help you live longer and protect you from cancer and heart disease. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 8, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Nutrition Source Type: blogs
OMI in a pediatric patient? Teenagers do get acute coronary occlusion, so don't automatically dismiss the idea.
Acute coronary syndrome in a pediatric patient?Written by Kirsten Morrissey, MD with edits by Bracey,
Grauer, Meyers, and Smith An older teen was transferred from an outside hospital
with elevated serum troponin and and ECG demonstrating ST elevations. The patient was obese and had a medical history of only recurrent tonsillitis status post tonsillectomy and adenoidectomy but was otherwise healthy and fully vaccinated. He reported 1.5 days of chest pain that started as substernal and crushing in nature awakening him from sleep and occasionally traveling to right side of neck. The pain ...
Source: Dr. Smith's ECG Blog - December 5, 2023 Category: Cardiology Authors: Bracey Source Type: blogs
Assessing Pentadecanoic Acid In Vitro
The work on pentadecanoic acid noted here is interesting, but should be taken with a grain of salt given that it is performed in vitro. In general, one should expect any given set of mechanisms in the cell to be associated with many different means of manipulation. It is interesting to see a fatty acid capable of touching on the same mechanisms as rapamycin, but remember that the ability to influence the same mechanistic targets does not necessarily translate to the same ability to produce a modest slowing of aging in animal studies. So the usual advice stands here, to wait for the animal studies before getting too excited...
Source: Fight Aging! - November 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
This Diet Lowers Cognitive Decline Risk By 17%
Adhering to this diet could not only lower the risk of heart disease but also boost cognitive function. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - November 21, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Dementia Source Type: blogs
Why Oval shaped ASD device are not popular ?
This study , though addressed a vital query ,is never meant to find the truth we want, as it has no oval vs circular device to compare the outcome.
Final message
It is strange ,cardiologists look for perfection and precision in every cardiac intervention, … while in case of ASD device closure, size is sacrosanct, but shapes, we are allowed to shrug off. May be things will change.
Reference
1.Song J, Lee SY, Baek JS, Shim WS, Choi EY. Outcome of transcatheter closure of oval shaped atrial septal defect with amplatzer septal occluder. Yonsei Med J. 2013 Sep;54(5):1104-9.
2.Roberson DA, Cui W, Patel D, ...
Source: Dr.S.Venkatesan MD - November 21, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized amplatzer asd device ASD device closure asd device erosion asd ostium secundum size ivc rim vs aortic rim oval asd oval vs circular defects ovoid asd device size vs shape of asd Source Type: blogs
A Therapy to Reduce Lipoprotein(a) Levels
The research and development community is ever in search of the next statin drug, and a way to reduce lipoprotein(a) levels looks very much like an alternative statin. Statins reduce the amount of cholesterol carried by LDL particles in the bloodstream. Lipoprotein(a) is a carrier of cholesterol, like LDL, and research has shown that high levels correlate with the development of atherosclerotic lesions, as is the case for LDL-cholesterol. That being so, one can't be all that optimistic that a treatment to reduce lipoprotein(a) will actually do much for disease risk. Statins reduce risk of stroke and heart attack resulting ...
Source: Fight Aging! - November 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 20th 2023
In this study, we attempted to further explain the role, exact mechanism and target of ICA in treating AD from the ferroptosis perspective. We found that ICA could improve the neurobehavioral, memory, and motor abilities of AD mice. It could lower the ferroptosis level and enhance the resistance to oxidative stress. After inhibition of MDM2, ICA could no longer improve the cognitive ability of AD mice, nor could it further inhibit ferroptosis. Network pharmacological analysis revealed that MDM2 might be the target of ICA action.
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Particulate Air Pollution and Its Effects on the Mechan...
Source: Fight Aging! - November 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Endothelial Cell Senescence in Atherosclerosis
Senescent cells accumulate throughout the body with age. They are created constantly due to stresses placed upon cells, and when somatic cells reach the Hayflick limit on replication, and are cleared by the immune system. This process of clearance slows down with age, unfortunately, and so a burden of lingering senescent cells begins to build up. Senescent cells are disruptive to tissue structure and function, even when present in comparatively small numbers relative to other cells in a tissue, as a result of the pro-growth, pro-inflammatory signals that they generate.
Atherosclerosis involves the generation of fatt...
Source: Fight Aging! - November 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Essential haematology for cardiologist
Forget NEJM, Circulation, JACC, for some time. Hope & wish every one of us is aware of a journal called Blood, bringing stunning and dramatic discoveries week after week ,about the most crucial fluid that sustains our life. The journal Blood is published by the American Society of Haematology since 1949. Its impact factor is currently 20.8, celebrating its 75th year of existence .
We know, heart disease consistently tops the global mortality and morbidity charts . Without blood, heart is just a purposeless organ with four empty chambers. More than ninety percent of the cardiac mortality happens due to freezing an...
Source: Dr.S.Venkatesan MD - November 15, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized 4 factor prothrombin complex concentrate 4 factor prothrombin complex concentrate. 4F-PCC : dilute thrombin time andexanet alfa anticoagulants bleeding risk Chromogenic anti-Xa assay dabigatron dapt doacs dTT: dilute Source Type: blogs
Essential hematology for cardiologist
Forget NEJM, Circulation, JACC, for some time. Hope & wish every one of us is aware of a journal called Blood, bringing stunning and dramatic discoveries week after week ,about the most crucial fluid that sustains our life. The journal Blood is published by the American Society of Hematology since 1949. Its impact factor is currently 20.8, celebrating its 75th year of existence .
We know, heart disease consistently tops the global mortality and morbidity charts . Without blood, heart is just a purposeless organ with four empty chambers. More than ninety percent of the cardiac mortality happens due to freezing and...
Source: Dr.S.Venkatesan MD - November 15, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized 4 factor prothrombin complex concentrate 4 factor prothrombin complex concentrate. 4F-PCC : dilute thrombin time andexanet alfa anticoagulants bleeding risk Chromogenic anti-Xa assay dabigatron dapt doacs dTT: dilute Source Type: blogs
Kento Health Raises $4.1 Million CAD to Bring AI to Cardiovascular Care
Dialogue Alumni’s New Startup is Gearing up to Strike Hard in the Battle Against the Leading Cause of Death
Montréal-based healthtech startup Kento Health has closed a $4.1 million CAD ($3 million USD) pre-seed financing round.
The round was led by Boreal Ventures and N49P and saw participation from Broom Ventures, Graphite Ventures, and several other strategic angel investors as well as an undisclosed US-based medical institution. Kento claims it is poised to make a substantial impact in the fight against the world’s leading cause of death by using technology like artificial intelligence (AI).
“This funding not...
Source: EMR and HIPAA - November 8, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Alex Norman Boreal Ventures Broom Ventures David Charbonneau Dialogue Health Graphite Ventures Health IT Funding Health IT Fundings Health IT Investment Jonah Davies Kento Kento Health Max Leca Source Type: blogs
Please Include “ mitral regurgitation ” in the “ Complication basket ” of hypertensive heart disease
Hypertension is a prevalent condition in the general population, as is mitral regurgitation (MR). For most of us, HT traditionally conveys a “singular meaning” that is, high pressure within blood vessels. We often forget that the origin of blood pressure begins right inside the heart, i.e, the left ventricle, which is guarded by two valves – the aortic and mitral. (Though we are aware, LVH is the classical response to HT),
Obviously, there will be signiifcant consequences to the structural integrity of these valves when LV pressure is raised beyond the tolerable limit of endocardial layers that line th...
Source: Dr.S.Venkatesan MD - November 5, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized effect of sht on mr functional MR hyppertension and mitral regurgitation secondary mr tips on mr amanagement valvular heart disease vasodilators in mr Source Type: blogs
Let us add “ mitral regurgitation ” in the “ Complication basket ” of hypertensive heart disease
Hypertension is a prevalent condition in the general population, as is mitral regurgitation (MR). For most of us, HT traditionally conveys a “singular meaning” that is, high pressure within blood vessels. We often forget that the origin of blood pressure begins right inside the heart, i.e, the left ventricle, which is guarded by two valves – the aortic and mitral. (Though we are aware, LVH is the classical response to HT),
Obviously, there will be signiifcant consequences to the structural integrity of these valves when LV pressure is raised beyond the tolerable limit of endocardial layers that line th...
Source: Dr.S.Venkatesan MD - November 5, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized effect of sht on mr functional MR hyppertension and mitral regurgitation secondary mr tips on mr amanagement valvular heart disease vasodilators in mr Source Type: blogs
