Comparing the Effect of Early Versus Delayed Metformin Treatment on Glycaemic Parameters Among Australian Adults With Incident Diabetes: Evidence Using a National General Practice Database
Clin Ther. 2024 Apr 1:S0149-2918(24)00067-5. doi: 10.1016/j.clinthera.2024.03.001. Online ahead of print.ABSTRACTPURPOSE: To compare the effect of early vs delayed metformin treatment for glycaemic management among patients with incident diabetes.METHODS: Cohort study using electronic health records of regular patients (1+ visits per year in 3 consecutive years) aged 40+ years with 'incident' diabetes attending Australian general practices (MedicineInsight, 2011-2018). Patients with incident diabetes were defined as those who had a) 12+ months of medical data before the first recording of a diabetes diagnosis AND b) a diag...
Source: Clinical Therapeutics - April 2, 2024 Category: Drugs & Pharmacology Authors: Mingyue Zheng Mumtaz Begum Carla De Oliveira Bernardo Nigel Stocks David Gonzalez-Chica Source Type: research
Protocol for a construct and clinical validation study of MyCog Mobile: a remote smartphone-based cognitive screener for older adults
Introduction
Annual cognitive screening in older adults is essential for early detection of cognitive impairment, yet primary care settings face time constraints that present barriers to routine screening. A remote cognitive screener completed on a patient’s personal smartphone before a visit has the potential to save primary care clinics time, encourage broader screening practices and increase early detection of cognitive decline. MyCog Mobile is a promising new remote smartphone-based cognitive screening app for primary care settings. We propose a combined construct and clinical validation study of MyCog Mobile.
M...
Source: BMJ Open - April 2, 2024 Category: General Medicine Authors: Young, S. R., McManus Dworak, E., Byrne, G. J., Jones, C. M., Yoshino Benavente, J., Yao, L., Curtis, L. M., Varela Diaz, M., Gershon, R., Wolf, M., Nowinski, C. Tags: Open access, General practice / Family practice Source Type: research
Prospective diagnostic accuracy study of history taking and physical examination for adults with vertigo in general practice: study protocol
Introduction
Vertigo is a prevalent and burdensome symptom. More than 80% of patients with vertigo are primarily treated by their general practitioner (GP) and are never referred to a medical specialist. Despite this therapeutic responsibility, the GP’s diagnostic toolkit has serious limitations. All recommended tests lack empirical evidence, because a diagnostic accuracy study on vestibular disorders (‘How well does test x discriminate between patients with or without target condition y?’) has never been performed in general practice. The VERtigo DIagnosis study aims to fill this gap.
Methods and analys...
Source: BMJ Open - April 2, 2024 Category: General Medicine Authors: Ross, A., Leemeyer, A.-M. R., Bruintjes, T. D., Cals, J. W. L., Bronstein, A., van Leeuwen, R. B., Lissenberg-Witte, B., van Vugt, V. A., Rutgers, S., Maarsingh, O. R. Tags: Open access, General practice / Family practice Source Type: research
Short-stay urgent hospital admissions of children with convulsions: A mixed methods exploratory study to inform out of hospital care pathways
ConclusionsSSAs for convulsions are different to SSAs for other conditions and our findings could inform new efficient convulsion-specific pre and post hospital pathways designed to improve family experiences and reduce admissions and readmissions. (Source: PLoS One)
Source: PLoS One - April 1, 2024 Category: Biomedical Science Authors: Cari Malcolm Source Type: research
Minor tranquillizers for short-term treatment of newly onset symptoms of anxiety and distress: a systematic review with network meta-analysis of randomized trials
AbstractUnspecific symptoms of anxiety and distress are frequently encountered in patients in both general practice and acute psychiatric services. Minor tranquillizers may be a treatment option when non-pharmacological interventions are insufficient or unavailable. We conducted a systematic review with network meta-analysis of the evidence for short-term (1 –4 weeks) pharmacological treatment of newly onset symptoms of anxiety and distress. We searched the PsycInfo, MEDLINE, EMBASE and Cochrane Library databases and extracted data following a predefined hierarchy of outcomes. We assessed risk of bias using the Cochrane...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 1, 2024 Category: Neuroscience Source Type: research
