The effects of telerehabilitation in adults with complex biventricular congenital heart conditions: protocol for a multi-centre, randomised controlled trial —CH-FIT
DiscussionIf found to be efficacious, telerehabilitation may be an alternative option for delivering exercise, improving health outcomes, and increasing accessibility to exercise programmes. Efficacy data is required to quantify the clinical significance of this delivery mode of exercise.Trial registrationACTRN12622000050752Trial registration date: 17 January 2022Trial registration URL:https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=382635&showOriginal=true&isReview=trueTrial registry name: Australian and New Zealand Clinical Trials Registry (Source: Trials)
Source: Trials - April 5, 2024 Category: Research Source Type: clinical trials

Early Discharge After Mitral and Tricuspid Edge-to-edge Repair: an Assessment of Feasibility and Safety
Conditions: Mitral Regurgitation; Tricuspid Regurgitation; Mitral Repair; Heart Failure Interventions: Behavioral: Early discharge protocol Sponsors: Oxford University Hospitals NHS Trust; Edwards Lifesciences Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 2, 2024 Category: Research Source Type: clinical trials

INSIDE: Identification of Genomic Screening Pathways in Cancer Patients With DNA Repair Alterations
Conditions: Prostate Cancer Sponsors: Fondazione del Piemonte per l ' Oncologia Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 28, 2024 Category: Research Source Type: clinical trials

Shockwave ™Peripheral Intravascular Lithotripsy Balloon for Advanced Endovascular Aortic Repair
Conditions: Thoracoabdominal Aortic Aneurysm, Without Mention of Rupture; Abdominal Aortic Aneurysm Without Rupture; Thoracic Aortic Aneurysm Without Rupture Interventions: Device: Shockwave ™ Peripheral Intravascular Lithotripsy Balloon M5+ Sponsors: Rede Optimus Hospitalar SA; Shockwave Medical, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 27, 2024 Category: Research Source Type: clinical trials

The REPAIR study: oral antibiotics to prevent infection and wound dehiscence after obstetric perineal tear —a double-blinded placebo controlled randomized trial
DiscussionReducing the risk of wound dehiscence and/or infection would decrease the number of control visits, prevent the need for longer antibiotic treatment, and possibly also decrease both short-term and long-term symptoms. This would be of great importance so the mother, her partner, and the baby could establish and optimize their initial family relation.Trial registrationThe conduction of this study is approved the 2/2 –2023 with the EU-CT number: 2022–501930-49–00. ClinicalTrials.gov Identifier: NCT05830162. (Source: Trials)
Source: Trials - March 27, 2024 Category: Research Source Type: clinical trials

Prophylactic Ilioinguinal Neurectomy During Open Tension-Free Inguinal Hernia Repair
Conditions: Ilioinguinal Nerve Section; Pain Prevention; Hernioplasty Interventions: Procedure: ilioinguinal nerve section Sponsors: Zagazig University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 25, 2024 Category: Research Source Type: clinical trials

The ARIA trial protocol: a randomised controlled trial to assess the clinical, technical, and cost-effectiveness of a cloud-based, ARtificially Intelligent image fusion system in comparison to standard treatment to guide endovascular Aortic aneurysm repair
This study aims to assess the benefit to patients, practitioners, and the health service of a novel image fusion medical device (Cydar EV), which allows this high-resolution 3D information to be available to operators at the time of surgery.MethodsThe trial is a multi-centre, open label, two-armed randomised controlled clinical trial of 340 patient, randomised 1:1 to either standard treatment in endovascular aneurysm repair or treatment using Cydar EV, a CE-marked medical device comprising of cloud computing, augmented intelligence, and computer vision. The primary outcome is procedural time, with secondary outcomes of pro...
Source: Trials - March 25, 2024 Category: Research Source Type: clinical trials

Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease
Conditions: Chronic Granulomatous Disease (CGD); X-Linked Chronic Granulomatous Disease Interventions: Biological: Base-edited hematopoietic stem and progenitor cells; Drug: Busulfan; Drug: Palifermin; Drug: Filgrastim; Drug: Plerixafor Sponsors: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 22, 2024 Category: Research Source Type: clinical trials

Intrathecal Non-preservative-free Morphine With Bupivacaine Versus Intrathecal Bupivacaine Alone for Analgesia in Unilateral Inguinal Hernia Repair Surgeries
Conditions: Pain, Postoperative Interventions: Drug: Morphine; Drug: Placebo Sponsors: Cairo University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 20, 2024 Category: Research Source Type: clinical trials

Estradiol Supplementation and Rotator Cuff Repair: A Preliminary Randomized Trial
Conditions: Rotator Cuff Tears; Rotator Cuff Injuries; Rotator Cuff Syndrome; Menopause Related Conditions; Menopause Interventions: Drug: Transdermal estrogen; Procedure: Rotator Cuff Repair Surgery Sponsors: University of Utah Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 19, 2024 Category: Research Source Type: clinical trials

Evaluation of Laparoscopic Cholecystectomy and Concomitant Paraumbilical Hernia Repair
Conditions: Abdominal Disorder Sponsors: Assiut University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 19, 2024 Category: Research Source Type: clinical trials

Ilioinguinal-iliohypogastric Nerve Block Prior to Shouldice Inguinal Hernia Repair
Conditions: Inguinal Hernia; Pain, Postoperative Sponsors: Shouldice Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 18, 2024 Category: Research Source Type: clinical trials

Flexor Injury Rehabilitation Splint Trial (FIRST): protocol for a pragmatic randomised controlled trial comparing three splints for finger flexor tendon repairs
DiscussionFIRST will compare the three splints with respect to clinical efficacy, complications, quality of life and cost-effectiveness. FIRST is a pragmatic trial which will recruit from 26 NHS sites to allow findings to be generalisable to current clinical practice in the UK. It will also provide significant insights into patient experiences of splint wear and how adherence to splinting may impact outcomes.Trial registrationISRCTN: 10236011 (Source: Trials)
Source: Trials - March 16, 2024 Category: Research Source Type: clinical trials

Safety and Pharmacokinetics of IMT504, an Immunomodulator and Tissue Repair Inducer
Conditions: Immune System Interventions: Drug: Oligonucleotides, Phosphorothioate Sponsors: Ministry of Public Health of the Province of La Rioja; Immunalgia Therapeutics S.A. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2024 Category: Research Source Type: clinical trials

Post-operative Lower Eyelid Massage for Prevention of the Lower Eyelid Scare Contracture After Subciliary Approach
Conditions: Zygomatic and Lefort II Fractures; Infraorbital Rim Fixation; Subciliary Approach Repair Interventions: Procedure: lower eyelid massage Sponsors: Chiang Mai University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 15, 2024 Category: Research Source Type: clinical trials