Reported case of recovery from rabies using intrathecal rabies immune globulin was flawed
Can J Neurol Sci. 2023 Nov 23:1-4. doi: 10.1017/cjn.2023.319. Online ahead of print.NO ABSTRACTPMID:37994535 | DOI:10.1017/cjn.2023.319 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - November 23, 2023 Category: Neurology Authors: Alan C Jackson Charles E Rupprecht Reeta S Mani Nidia Arechiga-Ceballos Darryn L Knobel Source Type: research
Reported case of recovery from rabies using intrathecal rabies immune globulin was flawed
Can J Neurol Sci. 2023 Nov 23:1-4. doi: 10.1017/cjn.2023.319. Online ahead of print.NO ABSTRACTPMID:37994535 | DOI:10.1017/cjn.2023.319 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - November 23, 2023 Category: Neurology Authors: Alan C Jackson Charles E Rupprecht Reeta S Mani Nidia Arechiga-Ceballos Darryn L Knobel Source Type: research
Reported case of recovery from rabies using intrathecal rabies immune globulin was flawed
Can J Neurol Sci. 2023 Nov 23:1-4. doi: 10.1017/cjn.2023.319. Online ahead of print.NO ABSTRACTPMID:37994535 | DOI:10.1017/cjn.2023.319 (Source: The Canadian Journal of Neurological Sciences)
Source: The Canadian Journal of Neurological Sciences - November 23, 2023 Category: Neurology Authors: Alan C Jackson Charles E Rupprecht Reeta S Mani Nidia Arechiga-Ceballos Darryn L Knobel Source Type: research
Octagam Trial Results Show Promise
Since the New England Journal of Medicine publication on intravenous immune globulin (IVIG) for dermatomyositis late last year, the data have proved a major lift for patient care, offering crucial new insights into how best to manage patients and clues about how to minimize risks.1 The ProDERM trial results also seem to have opened up... (Source: The Rheumatologist)
Source: The Rheumatologist - November 9, 2023 Category: Rheumatology Authors: Thomas R. Collins Tags: Conditions Drug Updates Myositis dermatomyositis intravenous immune globulin Octagam Source Type: research
Dosing Strategy of Immunoglobulin (IgG) Replacement Therapies in Obese and Overweight Patients with Primary Immunodeficiency Diseases (PIDDs): A Meta-Analysis of Clinical Trials
J Clin Pharmacol. 2023 Nov;63 Suppl 2:S110-S116. doi: 10.1002/jcph.2368.ABSTRACTThe current dosing strategy of immune globulin products for the treatment of primary immunodeficiency diseases (PIDDs) in the USA is based on total body weight (BW). The aim of our study was to assess the relationship between dose and trough level, and to determine whether an alternative dosing strategy should be considered for patients who are overweight or obese. We analyzed data in a total of 533 patients from 11 studies. We modeled the relationship between trough level and dose per week using a linear mixed model. We used an over-dispersed ...
Source: The Journal of Clinical Pharmacology - November 9, 2023 Category: Drugs & Pharmacology Authors: Tingting Zhou Million A Tegenge Basil Golding John Scott Source Type: research
Dosing Strategy of Immunoglobulin (IgG) Replacement Therapies in Obese and Overweight Patients with Primary Immunodeficiency Diseases (PIDDs): A Meta-Analysis of Clinical Trials
J Clin Pharmacol. 2023 Nov;63 Suppl 2:S110-S116. doi: 10.1002/jcph.2368.ABSTRACTThe current dosing strategy of immune globulin products for the treatment of primary immunodeficiency diseases (PIDDs) in the USA is based on total body weight (BW). The aim of our study was to assess the relationship between dose and trough level, and to determine whether an alternative dosing strategy should be considered for patients who are overweight or obese. We analyzed data in a total of 533 patients from 11 studies. We modeled the relationship between trough level and dose per week using a linear mixed model. We used an over-dispersed ...
Source: The Journal of Clinical Pharmacology - November 9, 2023 Category: Drugs & Pharmacology Authors: Tingting Zhou Million A Tegenge Basil Golding John Scott Source Type: research
Dosing Strategy of Immunoglobulin (IgG) Replacement Therapies in Obese and Overweight Patients with Primary Immunodeficiency Diseases (PIDDs): A Meta-Analysis of Clinical Trials
J Clin Pharmacol. 2023 Nov;63 Suppl 2:S110-S116. doi: 10.1002/jcph.2368.ABSTRACTThe current dosing strategy of immune globulin products for the treatment of primary immunodeficiency diseases (PIDDs) in the USA is based on total body weight (BW). The aim of our study was to assess the relationship between dose and trough level, and to determine whether an alternative dosing strategy should be considered for patients who are overweight or obese. We analyzed data in a total of 533 patients from 11 studies. We modeled the relationship between trough level and dose per week using a linear mixed model. We used an over-dispersed ...
Source: The Journal of Clinical Pharmacology - November 9, 2023 Category: Drugs & Pharmacology Authors: Tingting Zhou Million A Tegenge Basil Golding John Scott Source Type: research
Dosing Strategy of Immunoglobulin (IgG) Replacement Therapies in Obese and Overweight Patients with Primary Immunodeficiency Diseases (PIDDs): A Meta-Analysis of Clinical Trials
J Clin Pharmacol. 2023 Nov;63 Suppl 2:S110-S116. doi: 10.1002/jcph.2368.ABSTRACTThe current dosing strategy of immune globulin products for the treatment of primary immunodeficiency diseases (PIDDs) in the USA is based on total body weight (BW). The aim of our study was to assess the relationship between dose and trough level, and to determine whether an alternative dosing strategy should be considered for patients who are overweight or obese. We analyzed data in a total of 533 patients from 11 studies. We modeled the relationship between trough level and dose per week using a linear mixed model. We used an over-dispersed ...
Source: The Journal of Clinical Pharmacology - November 9, 2023 Category: Drugs & Pharmacology Authors: Tingting Zhou Million A Tegenge Basil Golding John Scott Source Type: research
Case Report: Insulin hypersensitivity in youth with type 1 diabetes
ConclusionAlthough rare, insulin hypersensitivity reactions negatively affect glycemic control and quality of life. These cases demonstrate the varying severity and presentation of insulin hypersensitivity reactions along with the limited success of various treatment approaches. Given the life-sustaining nature of insulin therapy, further studies are needed to better understand the underlying pathophysiology of insulin hypersensitivity and to develop targeted treatment approaches. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - October 20, 2023 Category: Endocrinology Source Type: research
A Korean family with RHD*DNT only detectable after anti-D alloimmunization
CONCLUSIONS: We recommend DNT individuals as candidates for Rh immune globulin prophylaxis during the perinatal period and transfusions with D- blood components. An anticipatory RHD genotyping is suggested for partial D family members to prevent potential partial D individuals from becoming alloimmunized.PMID:37852281 | DOI:10.1093/ajcp/aqad132 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 18, 2023 Category: Pathology Authors: Dong Woo Shin Gun-Hyuk Lee Hanah Kim Kyeong A So Yun Ji Hong Mina Hur Kyoung Un Park Source Type: research
A Korean family with RHD*DNT only detectable after anti-D alloimmunization
CONCLUSIONS: We recommend DNT individuals as candidates for Rh immune globulin prophylaxis during the perinatal period and transfusions with D- blood components. An anticipatory RHD genotyping is suggested for partial D family members to prevent potential partial D individuals from becoming alloimmunized.PMID:37852281 | DOI:10.1093/ajcp/aqad132 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 18, 2023 Category: Pathology Authors: Dong Woo Shin Gun-Hyuk Lee Hanah Kim Kyeong A So Yun Ji Hong Mina Hur Kyoung Un Park Source Type: research
Recent Advances in the Prevention and Management of Monkeypox Viral Infection in Humans
CONCLUSION: We have, herein, covered features of monkeypox viral biology that are important for risk assessment and getting ready for an outbreak of the monkeypox virus, with a focus on recent advances in knowledge of the virus's host range, evolutionary potential, and potential targets for neutralization.PMID:37842888 | DOI:10.2174/0113894501258154231008194028 (Source: Current Drug Targets)
Source: Current Drug Targets - October 16, 2023 Category: Drugs & Pharmacology Authors: Preeti Gujjar Rishabh Chaudhay Inderjeet Verma Nitin Bansal Sumeet Gupta Seema Bansal Source Type: research
Standardization of a multiplex assay to identify weak D types in a mixed-race Brazilian population
Immunohematology. 2023 Oct 16;39(3):93-100. doi: 10.2478/immunohematology-2023-016. eCollection 2023 Sep 1.ABSTRACTRH allele variability is caused by several types of variants, resulting in altered RhD and RhCE phenotypes. Most of the weak D phenotypes in European-derived populations are weak D types 1, 2, or 3, which are not involved in alloimmunization episodes. However, the Brazilian population is racially diverse, and the accuracy of molecular and serologic tests developed in recent years has allowed for the identification of other RH variants, that are common in the Brazilian population, such as weak D type 38 or weak...
Source: Immunohematology - October 16, 2023 Category: Hematology Authors: T C S Silva M R Dezan B R Cruz S S M Costa C L Dinardo J O Bordin Source Type: research
