Angiomatoid fibrous histiocytoma: Report of two cases, initially construed as sarcoma with unusual clinico-pathological features
Indian J Pathol Microbiol. 2022 Oct-Dec;65(4):921-924. doi: 10.4103/ijpm.ijpm_1468_20.ABSTRACTAngiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of uncertain differentiation with low metastatic potential, most commonly occurring in children, adolescents, and young adults, involving extremities. Due to its rare nature and diverse presentation, both clinically and morphologically, it is often misdiagnosed. It becomes important to correctly diagnose this lesion, given its distinct therapeutic implications. Here, we present the clinical, radiologic, and pathologic findings of two rare cases of AFH. Since AFH is...
Source: Indian Journal of Pathology and Microbiology - October 29, 2022 Category: Pathology Authors: Sunil Pasricha Garima Durga Anila Sharma Manish Pruthi Meenakshi Kamboj Gurudutt Gupta Ankush Jajodia Vivek Mahawar Venkata Pradeep Babu Koyyala Anurag Mehta Source Type: research
Angiomatoid fibrous histiocytoma: Report of two cases, initially construed as sarcoma with unusual clinico-pathological features
Indian J Pathol Microbiol. 2022 Oct-Dec;65(4):921-924. doi: 10.4103/ijpm.ijpm_1468_20.ABSTRACTAngiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of uncertain differentiation with low metastatic potential, most commonly occurring in children, adolescents, and young adults, involving extremities. Due to its rare nature and diverse presentation, both clinically and morphologically, it is often misdiagnosed. It becomes important to correctly diagnose this lesion, given its distinct therapeutic implications. Here, we present the clinical, radiologic, and pathologic findings of two rare cases of AFH. Since AFH is...
Source: Indian Journal of Pathology and Microbiology - October 29, 2022 Category: Pathology Authors: Sunil Pasricha Garima Durga Anila Sharma Manish Pruthi Meenakshi Kamboj Gurudutt Gupta Ankush Jajodia Vivek Mahawar Venkata Pradeep Babu Koyyala Anurag Mehta Source Type: research
Angiomatoid fibrous histiocytoma: Report of two cases, initially construed as sarcoma with unusual clinico-pathological features
Indian J Pathol Microbiol. 2022 Oct-Dec;65(4):921-924. doi: 10.4103/ijpm.ijpm_1468_20.ABSTRACTAngiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of uncertain differentiation with low metastatic potential, most commonly occurring in children, adolescents, and young adults, involving extremities. Due to its rare nature and diverse presentation, both clinically and morphologically, it is often misdiagnosed. It becomes important to correctly diagnose this lesion, given its distinct therapeutic implications. Here, we present the clinical, radiologic, and pathologic findings of two rare cases of AFH. Since AFH is...
Source: Indian Journal of Pathology and Microbiology - October 29, 2022 Category: Pathology Authors: Sunil Pasricha Garima Durga Anila Sharma Manish Pruthi Meenakshi Kamboj Gurudutt Gupta Ankush Jajodia Vivek Mahawar Venkata Pradeep Babu Koyyala Anurag Mehta Source Type: research
Epithelioid fibrous histiocytoma: three diagnostically challenging cases with novel ALK gene fusions, unusual storiform growth pattern, and a prominent spindled morphology
We report three EFHs with unusual histological presentation represented by a prominent/predominant spindle cell proliferation arranged in a variably storiform/whirling architectural pattern with or without stromal sclerosis. One of the cases closely resembled cellular fibrous histiocytoma. All three cases were immunohistochemically ALK-positive and were analyzed forALK gene rearrangements using a next-generation sequencing –based assay (FusionPlex Sarcoma Kit, ArcherDx). Three novel fusions, namelyAP3D1::ALK,COL1A::ALK, andLRRFIP2::ALK, were detected and further confirmed by FISH in all 3 cases and RT-PCR in 1 case. All ...
Source: Virchows Archiv - September 29, 2022 Category: Pathology Source Type: research
Operative Technique: Angiomatoid Fibrous Histiocytoma —Unique Case and Management
Conclusion The case presented is unique; the first reported AFH at the jugular foramen and the first reported case utilizing preoperative embolization. Preoperative embolization is a relatively safe technique that can improve the surgeon's ability to perform a maximally safe resection, which may decrease the need for adjuvant radiation in rare skull base tumors in young patients. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Journal of Neurological Surgery Reports)
Source: Journal of Neurological Surgery Reports - September 20, 2022 Category: Neurosurgery Authors: Mazur-Hart, David J. O'Neill, Brannan E. Pang, Brandi W. Hakar, Melanie H. Wood, Matthew D. Gupta, Sachin Sayama, Christina M. Liu, Jesse J. Dogan, Aclan Tags: Case Report Source Type: research
