UV light-mediated corneal crosslinking as (lymph)angioregressive pretreatment to promote graft survival after subsequent high-risk corneal transplantation (CrossCornealVision): protocol for a multicenter, randomized controlled trial
DiscussionBased on preclinical and early pilot clinical evidence, we want to test the novel concept of temporary (lymph)angioregressive pretreatment of high-risk eyes by CXL to promote subsequent corneal graft survival. So far, there is no evidence-based approach to reliably improve graft survival in the high-risk corneal transplantation setting available in clinical routine. If successful, this approach will be the first to promote graft survival in high-risk transplants. It will significantly improve vision and quality of life in patients suffering from corneal blindness.Trial registrationClinicalTrials.gov NCT05870566. ...
Source: Trials - March 6, 2024 Category: Research Source Type: clinical trials
Effects of Acupoint Massage Around Eyes on Ocular Biological Indexes
Conditions: Investigating the Effects of Periocular Acupressure on Ocular Biological Indicators Interventions: Other: acupressure Sponsors: Zhongnan Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 5, 2024 Category: Research Source Type: clinical trials
Efficacy and Safety of Liposomal Bupivacaine Under ERAS Concept for Postoperative Analgesia of Ultrasound-Guided QLB in Gynecologic Laparoscopic Patients: A Randomized, Single-blind, Active-Controlled Clinical Study
Conditions: Pharmacological Action Interventions: Drug: Ropivacaine injection; Drug: Bupivacaine liposome Sponsors: Tianjin Medical University General Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 1, 2024 Category: Research Source Type: clinical trials
The Diagnostic Accuracy of Advanced Imaging in Identifying Suspected Skin Cancer (Basal Cell Carcinoma) Around the Eyes
Conditions: BCC - Basal Cell Carcinoma; BCC; Skin Diseases; Eyelid Tumor; Eyelid Diseases Sponsors: Vejle Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 26, 2024 Category: Research Source Type: clinical trials
iLux Treatment for Meibomian Gland Dysfunction
Conditions: Meibomian Gland Dysfunction; Eyes Dry Chronic Interventions: Device: iLUX Treatment System Sponsors: Cl ínica de Oftalmología de Cali S.A Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 26, 2024 Category: Research Source Type: clinical trials
Comparing the effects of pulsed and radiofrequency catheter ablation on quality of life, anxiety, and depression of patients with paroxysmal supraventricular tachycardia: a single-center, randomized, single-blind, standard-controlled trial
ConclusionsOur study provided new and meaningful evidence that PFA was effective in significantly improving QOL and decreasing anxiety and depression in PFA patients.Trial registrationChinese Clinical Trial Registry, ChiCTR2200060272. (Source: Trials)
Source: Trials - February 24, 2024 Category: Research Source Type: clinical trials
Efficacy of Personalized Repetitive Transcranial Magnetic Stimulation Protocol Based on Functional Reserve to Enhance Upper Limb Function in Subacute Stroke Patients: A Multi Center, Randomized, Single Blind, Parallel Group Prospective Clinical Trial
Conditions: Stroke Interventions: Device: Group 1-1; Device: Group 1-2; Device: Group 2-1; Device: Group 2-2; Device: Group 3-1; Device: Group 3-2 Sponsors: Samsung Medical Center; National Research Foundation of Korea; Ministry of Food and Drug Safety, Korea; Seoul National University Hospital; Bucheon St. Mary ' s Hospital; Saint Vincent ' s Hospital, Korea; Severance Hospital; Kumoh National Institute of Technology; NEUROPHET Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 21, 2024 Category: Research Source Type: clinical trials
Epithelium-on Cross-linking Versus Observation of Fellow Eyes of Patients With Unilateral Clinically Evident Keratoconus
Conditions: Keratoconus Interventions: Procedure: Epithelium-on corneal cross-linking (epi-on CXL) Sponsors: Assiut University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 20, 2024 Category: Research Source Type: clinical trials
Simultaneous pHototherapeutic Keratectomy and corneAl Collagen cRosslinking in Eyes With Keratoconus: a Randomized Trial (SHARK)
Conditions: Keratoconus Interventions: Procedure: Corneal collagen cross linking (CXL); Procedure: Transepithelial phototherapeutic keratectomy (t-PTK) Sponsors: Oslo University Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 16, 2024 Category: Research Source Type: clinical trials
Collection of Ocular Surface Impressions Cytology of the Living Eye From Patients With Dry Eyes or Limbal Stem Cell Deficiency.
Conditions: Eye Diseases Interventions: Diagnostic Test: EYEPRIM Sponsors: Centre Hospitalier Universitaire de Saint Etienne; Laboratoire Biologie, Ing énierie et Imagerie de la Greffe de Cornée (BiiGC) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 13, 2024 Category: Research Source Type: clinical trials
Testing Tactile Aids With Blind Subjects
Conditions: Vision, Low; Blindness Interventions: Behavioral: Single bump acuity; Behavioral: Optimal spacing between bumps; Behavioral: Improving signal from a single bump with designer materials Sponsors: University of Delaware Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 2, 2024 Category: Research Source Type: clinical trials
Health economic evaluation of a nurse-assisted online eye screening in home healthcare to reduce avoidable vision impairment (iScreen): study protocol for a cluster randomized controlled trial
DiscussionAn eye screening for populations at risk contributes to the detection of undiagnosed and untreated vision impairment. This may reduce the health-related consequences of vision loss and the high economic burden associated with vision impairment.Trial registrationClinicalTrials.gov NCT06058637. Registered on 27 September 2023. (Source: Trials)
Source: Trials - February 2, 2024 Category: Research Source Type: clinical trials
Transpalpebral electrical stimulation for the treatment of retinitis pigmentosa: study protocol for a series of N-of-1 single-blind, randomized controlled trial
DiscussionThe trial will evaluate the efficacy and safety of microcurrent stimulation on RP and provide high-quality evidence for clinical application through N-of-1 trial.Trial registrationChinese Clinical Trial Registry; ChiCTR2300067357;https://www.chictr.org.cn/showproj.html?proj=174635. Registered on 5 January 2023 (Source: Trials)
Source: Trials - January 27, 2024 Category: Research Source Type: clinical trials
Efficacy of an aloe vera, chamomile, and thyme cosmetic cream for the prophylaxis and treatment of mild dermatitis induced by radiation therapy in breast cancer patients: a controlled clinical trial (Alantel Trials)
The objective was to evaluate the effect of a cream (Alantel) based on natural products at high concentrations for the preventive and cura tive treatment (at early stages) of radiation-induced dermatitis in patients with breast cancer.MethodsOur protocol is an experimental, prospective, triple-blind, multicenter, controlled clinical trial with two parallel arms. The experimental group will be treated with Alantel, while the control group will receive another moisturizing cream. Radiotherapy oncology professionals will recruit a total of 88 patients (44 per comparison group) with breast cancer who will receive radiotherapy ...
Source: Trials - January 25, 2024 Category: Research Source Type: clinical trials
A Novel Target Delineation Scheme in High-grade Glioma Patients: a Randomized Single-blind Clinical Trial
Conditions: Radiation Toxicity; MRI Simulated Positioning; High Grade Glioma; Progression-free Survival; Overall Survival Interventions: Radiation: reduced target volume; Radiation: EORTC (European organisation for research and treatment of cancer) target volume Sponsors: Zhujiang Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 22, 2024 Category: Research Source Type: clinical trials
