TWiV 1063: Childhood paralysis with Kevin Messacar
Kevin Messacar visits the Incubator to discuss his career as a pediatric infectious disease physician, and his work on enteroviruses that are associated with acute flaccid myelitis and other diseases. Host: Vincent Racaniello Guest: Kevin Messacar Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Global Scholar Travel Awards (ASV) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Emergence of EV-D68 (Microbio Spectr) 2014 outbreak of EV-D68 (J Med Virol) EV-D68 shedding in households (...
Source: This Week in Virology - MP3 Edition - November 19, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 936: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses detection of a highly divergent type 3 vaccine-derived poliovirus in a child with a severe primary immunodeficiency disorder, severe respiratory illnesses associated with rhinoviruses and/or enteroviruses including EV-D68, effects of vaccination and previous infection on Omicron infections in children, COVID-19-associated hospitalizations among vaccinated and unvaccinated adults 18 years or older in 13 US states, effectiveness of COVID-19 vaccines over time prior to Omicron emergence in Ontario, Canada, nasal IgA wanes 9 months after hospitalization with COVID-19 an...
Source: This Week in Virology - MP3 Edition - September 17, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 930: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses antibody response against nonpoliovirus enteroviruses, clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain, object and surface contamination with monkeypox virus, monkeypox virus infection in humans across 16 countries, clinical characteristics of ambulatory and hospitalized patients with monkeypox virus infection, compassionate use of Tecovirimat for the treatment of monkeypox infection, monitoring of Pfizer-BioNTech vaccine among children, Pfizer and BioNTech announce updated vaccine data supporting efficacy in children, d...
Source: This Week in Virology - MP3 Edition - August 27, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 866: EV antibodies rEVolutionize our thinking
Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis and seroprevalence studies. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit Brianne Barker, and Amy Rosenfeld Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ABRCMS ePoster Spring Symposium for Emerging Scientists Cross-reactive enterovirus antibodies (mBio) Poliovirus receptor transgenic mice (virology blog) Timestamps by Jolene. Thanks! Weekly Picks Di...
Source: This Week in Virology - MP3 Edition - February 13, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 832: Heavy metal flu fighters
TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral influenza virus vaccine. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Smallpox vials contain vaccinia virus (6abc.com) European re-emergence of enterovirus D68 (Eurosurveill) Efficacy of inactivated SARS-CoV-2 vaccine (Lancet) Cellular correlates of protection for oral flu vaccine (Cell Host M...
Source: This Week in Virology - MP3 Edition - November 21, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 604: Oral poliovaccine to prevent SARS-CoV-2 infection
Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2. Host: Vincent Racaniello Guest: Kostya Chumakov Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Nonpathogenic enteroviruses to prevent human disease (pdf) OPV for COVID-19 (pdf) Enteroviruses to prevent human infections (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv (Source: This Week in Virology - MP3 Edition)
Source: This Week in Virology - MP3 Edition - April 21, 2020 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 572: Your EV-D68th nervous breakdown
Amy joins the TWiV team to review evidence that enterovirus D68 is an etiologic agent of childhood paralysis, and her finding that the ability of the virus to infect cells of the nervous system is not a recently acquired property. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode EV-D68 antibodies in humans before 2014 outbreak (Emerg Inf Dis) Enterovirus antibodies in CSF of AFM patients (mBio) Serology implicates enteroviruses in AFM (Nat Med) EV-D68 neurotropism ...
Source: This Week in Virology - MP3 Edition - November 3, 2019 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 568: Karolinska viral
In the second episode from the Karolinska Institute in Stockholm, Vincent speaks with Jan Albert, Petter Brodin, and Anna Smed-Sörensen about their work on enterovirus D68, systems immunology, and human pulmonary viral infection and inflammation. Hosts: Vincent Racaniello Guests: Jan Albert, Petter Brodin, and Anna Smed-Sörensen Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Karolinska Huddinge Evolution of enterovirus D68 (Virus Evol) Maternal anti-viral antibodies in newborns (Nat Med) Respiratory phagocytes in human influenza (Front Immunol) Timestamps b...
Source: This Week in Virology - MP3 Edition - October 6, 2019 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 567: Outbreaks and a breakout
The TWiV team covers outbreaks of eastern equine encephalitis virus in the US and poliovirus in the Philippines, and explain how a chemokine induced by HIV-1 infection helps release more virus particles from cells. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Poliomyelitis returns to the Philippines (Mashable, virology blog) EEE in the USA (Am J Trop Med Hyg) Chemokine helps HIV-1 release (eLIFE) Image credit Letters read on TWiV 567 Timestamps by Jolene....
Source: This Week in Virology - MP3 Edition - September 29, 2019 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 522: Readers of the lost ORF
The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Genome-edited babies (Nature) Second CRISPR pregnancy? (MIT Tech Rev) Naturally occurring DNA virus of Drosophila (PLoS Path) Upstream protein coding region in enterovirus genome We missed it in 1988! (J Virol) L...
Source: This Week in Virology - MP3 Edition - December 2, 2018 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 367: Two sides to a Coyne
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
Guests: Carolyn Coyne and Coyne Drummond
Two Coynes join the TWiV overlords to explain their three-dimensional cell culture model of polarized intestinal for studying enterovirus infection.
Links for this episode
Carolyn and placentas on TWiV 193
Three-dimensional cell culture model (mSphere)
Bioreactor video (JoVE)
Neurovirologist Richard T. Johnson, 84 (Hopkins and virology blog)
Tardigrade HGT disputed (BioRxiv)
Exaptation of archaeal virus capsid protein from Cas4 (Biol Dir)
Image credit
Letters read on TWiV 367
This ep...
Source: This Week in Virology - MP3 Edition - December 13, 2015 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 331: Why is this outbreak different from all other outbreaks?
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiV team discusses the possible association of the respiratory pathogen enterovirus D68 with neurological disease.
This episode is sponsored by SciMed Solutions and ASM Education.
Links for this episode
Clusters of AFP associated with enterovirus D68 (Lancet)
Novel outbreak enterovirus D68 strain (Lancet Inf Dis)
Enterovirus D68 in Norway (Euro Surveill)
Unknown enemy (Nature)
Enterovirus D68 on TWiV 302
Letters read on TWiV 331
Timestamps by Jennifer. Thank you!
Weekly Science Picks
Alan - OU0POLIO ham rad...
Source: This Week in Virology - MP3 Edition - April 5, 2015 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 328: Lariat tricks in 3D
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
The TWiVocateurs discuss how the RNA polymerase of enteroviruses binds a component of the splicing machinery and inhibits mRNA processing.
Links for this episode
Viral polymerase binds Prp8 to inhibit mRNA splicing (PLoS Path)
Prp8 protein of the spliceosome (RNA)
Nuclear entry of poliovirus RdRp (Virol)
RNA processing (TWiV 216)
Measles in USA (CDC)
Principles of Microbial Diversity
Journal of Microbiology & Biology Education
Letters read on TWiV 3...
Source: This Week in Virology - MP3 Edition - March 15, 2015 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Enterovirus D68: The Other 'E' Virus Causing Illness Now
There is another 'E' virus that clinicians should be concerned about right now. Learn more here—Paul G. Auwaerter, MD, offers his perspective. (Source: Medscape Pediatrics Podcast)
Source: Medscape Pediatrics Podcast - December 4, 2014 Category: Pediatrics Authors: Medscape Source Type: podcasts
Respiratory Illness and Enterovirus D68: Clinical Guidance
What do we know about enterovirus D68? Where did it come from, and what can be done about it? (Source: Medscape Infectious Disease Podcast)
Source: Medscape Infectious Disease Podcast - September 19, 2014 Category: Infectious Diseases Authors: Medscape Source Type: podcasts
