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Enterovirus 71 Activates Plasmacytoid Dendritic Cell-Dependent PSGL-1 Binding Independent of Productive Infection
J Immunol. 2024 Apr 17:ji2300407. doi: 10.4049/jimmunol.2300407. Online ahead of print.ABSTRACTEnterovirus 71 (EV71) is a significant causative agent of hand, foot, and mouth disease, with potential serious neurologic complications or fatal outcomes. The lack of effective treatments for EV71 infection is attributed to its elusive pathogenicity. Our study reveals that human plasmacytoid dendritic cells (pDCs), the main type I IFN-producing cells, selectively express scavenger receptor class B, member 2 (SCARB2) and P-selectin glycoprotein ligand 1 (PSGL-1), crucial cellular receptors for EV71. Some strains of EV71 can repli...
Source: Journal of Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Xuyuan Zhang Zhao Yin Jialong Zhang Hao Guo Jingyun Li Xiaohua Nie Shouli Wang Liguo Zhang Source Type: research

Enterovirus Infection in Preterm Quadruplets with Clinical Presentation of Neonatal Late-Onset Sepsis: a Case Report
Z Geburtshilfe Neonatol. 2024 Apr 15. doi: 10.1055/a-2279-6803. Online ahead of print.ABSTRACTThis is the unusual case of concurrent late-onset sepsis caused by enteroviruses in preterm quadruplets in a neonatal ward. While viral infections are an important differential diagnosis of bacterial sepsis in the outpatient setting, the occurrence in a neonatal ward with strict prophylactic hygiene measures is unusual. In this case, transmission of enteroviruses via breast milk appears possible.PMID:38621739 | DOI:10.1055/a-2279-6803 (Source: Zeitschrift fur Geburtshilfe und Neonatologie)
Source: Zeitschrift fur Geburtshilfe und Neonatologie - April 15, 2024 Category: Perinatology & Neonatology Authors: Viktor Seifert Lena B öck Johannes Wirbelauer Source Type: research

Long-term variations of urban –Rural disparities in infectious disease burden of over 8.44 million children, adolescents, and youth in China from 2013 to 2021: An observational study
The objective of our study was to evaluate the long-term urban –rural disparities in infectious diseases among children, adolescents, and youths in China, while also examining the specific diseases driving these disparities. Methods and findingsThis observational study examined data on 43 notifiable infectious diseases from 8,442,956 cases from individuals aged 4 to 24 years, with 4,487,043 cases in urban areas and 3,955,913 in rural areas. The data from 2013 to 2021 were obtained from China ’s Notifiable Infectious Disease Surveillance System. The 43 infectious diseases were categorized into 7 categories: vaccine-prev...
Source: PLoS Medicine - April 12, 2024 Category: Internal Medicine Authors: Li Chen Source Type: research

Analysis of mild and severe neonatal enterovirus infections in a Chinese neonatal tertiary center: a retrospective case-control study
ConclusionWe found significant differences between mild and severe cases of neonatal enterovirus infection with respect to complications, laboratory findings, and enterovirus serotypes. It is crucial to exercise caution when newborns exhibit symptoms of sepsis, during an enterovirus outbreak. Anemia, thrombocytopenia, abnormal liver function, and coagulation dysfunction should be monitored closely as they could indicate the presence of a severe enteroviral infection. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 12, 2024 Category: Microbiology Source Type: research

Inhibition of ESCRT-independent extracellular vesicles biogenesis suppresses enterovirus 71 replication and pathogenesis in mice
Int J Biol Macromol. 2024 Apr 6:131453. doi: 10.1016/j.ijbiomac.2024.131453. Online ahead of print.ABSTRACTEnterovirus 71 (EV71) causes hand-foot-and-mouth disease (HFMD), neurological complications, and even fatalities in infants. Clinically, the increase of extracellular vesicles (EVs) in EV71 patients' serum was highly associated with the severity of HFMD. EV71 boosts EVs biogenesis in an endosomal sorting complex required for transport (ESCRT)-dependent manner to facilitate viral replication. Yet, the impact of EVs-derived from ESCRT-independent pathway on EV71 replication and pathogenesis is highly concerned. Here, we...
Source: International Journal of Biological Macromolecules - April 8, 2024 Category: Biochemistry Authors: Yicong Liang Yue Kong Menglan Rao Xing Zhou Chengcheng Li Yi Meng Yanxi Chen Hongjian Li Zhen Luo Source Type: research

Viruses, Vol. 16, Pages 573: Quantitation of Enterovirus A71 Empty and Full Particles by Sedimentation Velocity Analytical Ultracentrifugation
In this study, we analyzed the application of sedimentation velocity analytical ultracentrifugation (SV-AUC) in characterizing the EPs and FPs of EV71. Our results showed that the proportions of the two forms could be quantified simultaneously by SV-AUC. We also determined the repeatability and accuracy of this method and found that both parameters were satisfactory. We assessed SV-AUC for bulk vaccine quality control, and our findings indicated that SV-AUC can be used effectively to analyze the percentage of EPs and FPs and monitor the consistency of the process to ensure the quality of the vaccine. (Source: Viruses)
Source: Viruses - April 8, 2024 Category: Virology Authors: Anna Yang Yun Luo Jie Yang Tingbo Xie Wenhui Wang Xin Wan Kaiwen Wang Deqin Pang Dongsheng Yang Hanyu Dai Jie Wu Shengli Meng Jing Guo Zejun Wang Shuo Shen Tags: Article Source Type: research

Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing
CONCLUSION: Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral encephalitis. It is also a useful tool for the high-volume screening of clinical samples.PMID:38582993 | DOI:10.3967/bes2024.032 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Ya Li Zhang Wen Zhe Su Rui Chen Wang Yan Li Jun Feng Zhang Sheng Hui Liu Dan He Hu Chong Xiao Xu Jia Yu Yin Qi Kai Yin Ying He Fan Li Shi Hong Fu Kai Nie Guo Dong Liang Yong Tao Song Tao Xu Chao Feng Ma Huan Yu Wang Source Type: research

Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing
CONCLUSION: Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral encephalitis. It is also a useful tool for the high-volume screening of clinical samples.PMID:38582993 | DOI:10.3967/bes2024.032 (Source: Herpes)
Source: Herpes - April 7, 2024 Category: Infectious Diseases Authors: Ya Li Zhang Wen Zhe Su Rui Chen Wang Yan Li Jun Feng Zhang Sheng Hui Liu Dan He Hu Chong Xiao Xu Jia Yu Yin Qi Kai Yin Ying He Fan Li Shi Hong Fu Kai Nie Guo Dong Liang Yong Tao Song Tao Xu Chao Feng Ma Huan Yu Wang Source Type: research