Randomised, double-blind, placebo controlled multi-centre study to assess the efficacy, tolerability and safety of Enterosgel ® in the treatment of irritable bowel syndrome with diarrhoea (IBS-D) in adults
DiscussionThis is the first large scale randomised controlled trial investigating Enterosgel ® in IBS-D. A study design with blinded phase followed by an open-label phase was chosen to encourage participation and study completion. Demonstrating that Enterosgel® is effective and safe in IBS-D could encourage adoption by patients and healthcare professionals and foster future clinical trial s assessing its use in related conditions.Trial registrationISRCTN17149988. Prospectively registered on 14 November 2017. (Source: Trials)
Source: Trials - January 29, 2020 Category: Research Source Type: clinical trials
Results of FilmArray ® Gastro-intestinal Panel and Serum Procalcitonin in Acute Colitis and Infectious Diarrhea in the ER
Condition: Acute Diarrhoea, Acute Colitis of Presumed Infectious Origin Intervention: Device: Filmarray PCR multiplex-PCT assay Sponsors: Assistance Publique - Hôpitaux de Paris; Biofire Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 23, 2020 Category: Research Source Type: clinical trials
A double-blind placebo-controlled trial of azithromycin to reduce mortality and improve growth in high-risk young children with non-bloody diarrhoea in low resource settings: the Antibiotics for Children with Diarrhoea (ABCD) trial protocol
DiscussionExpanding the treatment of acute watery diarrhoea in high-risk children to include an antibiotic may offer an opportunity to reduce deaths. These benefits may result from direct antimicrobial effects on pathogens or other incompletely understood mechanisms including improved nutrition, alterations in immune responsiveness or improved enteric function. The expansion of indications for antibiotic use raises concerns about the emergence of antimicrobial resistance both within treated children and the communities in which they live. ABCD will monitor antimicrobial resistance. The ABCD trial has important policy impli...
Source: Trials - January 12, 2020 Category: Research Source Type: clinical trials
