A double-blind placebo-controlled trial of azithromycin to reduce mortality and improve growth in high-risk young children with non-bloody diarrhoea in low resource settings: the Antibiotics for Children with Diarrhoea (ABCD) trial protocol

DiscussionExpanding the treatment of acute watery diarrhoea in high-risk children to include an antibiotic may offer an opportunity to reduce deaths. These benefits may result from direct antimicrobial effects on pathogens or other incompletely understood mechanisms including improved nutrition, alterations in immune responsiveness or improved enteric function. The expansion of indications for antibiotic use raises concerns about the emergence of antimicrobial resistance both within treated children and the communities in which they live. ABCD will monitor antimicrobial resistance. The ABCD trial has important policy implications. If the trial shows significant benefits of azithromycin use, this may provide evidence to support reconsideration of antibiotic indications in the present World Health Organization diarrhoea management guidelines. Conversely, if there is no evidence of benefit, these results will support the current avoidance of antibiotics except in dysentery or cholera, thereby avoiding inappropriate use of antibiotics and reaffirming the current guidelines.Trial registrationClinicaltrials.gov,NCT03130114. Registered on April 26 2017.
Source: Trials - Category: Research Source Type: clinical trials

Related Links:

Publication date: Available online 17 February 2020Source: LWTAuthor(s): Jennifer V. Félix-Medina, Julio Montes-Ávila, Cuauhtémoc Reyes-Moreno, J. Xiomara K. Perales-Sánchez, Mario A. Gómez-Favela, Ernesto Aguilar-Palazuelos, Roberto Gutiérrez-DoradoAbstractSnacks directly expanded (second-generation) are trendy in the market, but considered products of poor nutritional due to usually made with corn starch. In this research, optimization of the extrusion process variables and the bean flour inclusion level was carried out to develop optimized expanded snacks (OES) with high nutriti...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
ConclusionUA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary UA in cancer prevention or as adjuvant therapy is promising.
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research
J. Mater. Chem. A, 2020, Accepted Manuscript DOI: 10.1039/D0TA00888E, PaperSimeng Li, Xuhuan Yang, Siyuan Yang, Qiongzhi Gao, Shengsen Zhang, Xiaoyuan Yu, Yueping Fang, Shihe Yang, Xin Cai The emerging flexible/wearable electronics have greatly stimulated the research on portable batteries with high specific energy and excellent mechanical properties. State-of-the-art zinc-air batteries (ZABs) are a potential candidate for flexible... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Diamond Princess evacuations begin as Japan warns outbreak ‘entering new phase’. Follow latest updatesRussian court orders woman who fled quarantine back to hospitalWhat is coronavirus and what should I do if I have symptoms?Tokyo marathon cancels mass race over coronavirus scareShare your experiences5.23pmGMTChina ’s president Xi Jinping spelled out his plan to contain the coronavirus crisis at a meeting of the core Chinese leadership today, Reuters reports.In the speech, Xi admitted there were “shortcomings” in China’s emergency response systems and said local officials would be punish...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak China Japan Hong Kong Australia news Asia Pacific Infectious diseases Science World news Source Type: news
BACKGROUND: Depressive symptoms are common among older people which are associated with disability, morbidity and mortality. The aim of this study was to determine the associated risk factors for depressive symptoms among older people in Bangladesh. ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
[MSF] MSF has been providing healthcare in Cabo Delgado province, one of the poorest and most isolated regions of Mozambique, since February 2019. Early activities were rapidly disrupted by Cyclone Kenneth in late April 2019, and replaced with emergency response to displacement and cholera. Since then, MSF has been building up healthcare activities. Bruno Cardoso, MSF's project coordinator, has just returned from Mozambique and tells us more about the situation and what MSF does there.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Conditions:   Nutritional Risk;   Malnutrition Intervention:   Sponsors:   Eva Biringer;   University of Bergen;   Western Norway University of Applied Sciences;   Helse-Bergen HF Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Consumer Behavior Intervention:   Behavioral: Assess opinons on the milk beverages Sponsors:   Clinical Nutrition Research Center, Illinois Institute of Technology;   Food and Drug Administration (FDA) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A child wades through water on her way to school in Kurigram district of northern Bangladesh during floods in August 2016. Credit: UNICEF/AkashBy Fairuz AhmedNEW YORK, Feb 17 2020 (IPS) For any riverine country, the state of the water body around big cities and conditions of major rivers hold a leadership position in the overall climate effects and how the water body is protected and preserved impacts the entire economy and living standards of that country. Bangladesh is renowned for the geomorphic features that include massive rivers flowing throughout the country. Within the border of Bangladesh lie the bottom reaches of...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Asia-Pacific Biodiversity Climate Change Development & Aid Economy & Trade Energy Environment Featured Food & Agriculture Headlines Health Labour TerraViva United Nations Trade & Investment Water & Sanitation Source Type: news
[East African] Kenya, Sri Lanka, Philippines, Vietnam, Kazakhstan, Cambodia and Nepal are the top seven low and middle-income countries most vulnerable to direct adverse economic losses due to the coronavirus (COVID-19) outbreak in China
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
More News: Antimicrobial Resistance | Azithromycin | Bangladesh Health | Children | Cholera | Diarrhoea | Dysentery | India Health | International Medicine & Public Health | Kenya Health | Malawi Health | Mali Health | Nutrition | Pakistan Health | Research | Tanzania Health | WHO | Zinc | Zithromax