Corbus begins Resunab’s Phase II trial for Dermatomyositis
Corbus Pharmaceuticals Holdings has enrolled the first patient in its phase II clinical trial, which will assess the safety and efficacy of Resunab to treat Dermatomyositis, a rare and inflammatory muscle disease accompanied by skin rashes. (Source: Drug Development Technology)
Source: Drug Development Technology - July 13, 2015 Category: Pharmaceuticals Source Type: news
Picture of Dermatomyositis
Title: Picture of DermatomyositisCategory: ImagesCreated: 10/19/2009 12:00:00 AMLast Editorial Review: 12/8/2014 12:00:00 AM (Source: MedicineNet Skin General)
Source: MedicineNet Skin General - December 8, 2014 Category: Dermatology Source Type: news
RheumShorts: Complications of Dermatomyositis (CME/CE)
(MedPage Today) -- Fatal infections can result in severe cases. (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - October 30, 2014 Category: Dermatology Source Type: news
VTE Risk High in Autoimmune Muscle Disease
(MedPage Today) -- Patients with the inflammatory myopathies polymyositis and dermatomyositis had markedly elevated risks for venous thromboembolic events, a population-based study in Canada found. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - September 9, 2014 Category: Cardiology Source Type: news
Could This Rash Mean Malignancy?Could This Rash Mean Malignancy?
Jonathan Kay describes a patient with an extensive rash that initially suggested dermatomyositis but turned out to auger something more serious. Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 19, 2014 Category: Consumer Health News Tags: Rheumatology Commentary Source Type: news
What Causes Leg Pain?
Discussion
“Growing pains” of the legs are a common complaint in children. Heterogeneous studies from 1928-2004 have found prevalence rates of 2.6-49.4% in children ages 4-19. The studies are heterogeneous because of time, location, and especially definition of growing pains. A study of 1445, 4-6 year olds in 2004 using a validated tool showed a prevalence rate of 36.9%.
The definition of growing pains used by Peterson in the 2004 study is chronic “…intermittent (nonarticular) pains in both legs that generally occur late in the day or at night…” with a normal physical examination and l...
Source: PediatricEducation.org - May 19, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Air Pollution Tied to Kids' Muscle Disease
(MedPage Today) -- Prenatal exposure to tobacco smoke, air pollution, and occupational contaminants was associated with an increased risk of children later developing juvenile dermatomyositis, a small Brazilian study suggested. (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - April 24, 2014 Category: Pediatrics Source Type: news
Autoantibodies, Cancer, and DermatomyositisAutoantibodies, Cancer, and Dermatomyositis
Investigators have linked antibodies to NXP-2 and TIF1-gamma to cancer in patients with dermatomyositis, but are the findings clinically actionable? Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 27, 2013 Category: Consumer Health News Tags: Rheumatology Viewpoint Source Type: news
What Causes Muscle Weakness?
Discussion
Muscle tone is the slight tension that is felt in a muscle when it is voluntarily relaxed. It can be assessed by asking the patient to relax and then taking the muscles through a range of motion such as moving the wrists, forearm and upper arm. Muscle strength is the muscle’s force against active resistance. Impaired strength is called weakness or paresis. There are 5 levels of muscle strength.
0 = No muscle contraction detected
1 = Barely detected flicker of contraction
2 = Active movement with gravity eliminated
3 = Active movement against gravity
4 = Active movement against gravity and some resistance
...
Source: PediatricEducation.org - December 9, 2013 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Researchers develop specific tests to identify cancer biomarkers in dermatomyositis
Researchers from major universities in the U.S. have developed specific tests to identify cancer biomarkers in patients with dermatomyositis - a systemic inflammatory disease associated with increased risk of malignancy. According to study findings published in the American College of Rheumatology (ACR) journal, Arthritis & Rheumatism, the assays detect antibodies against anti-transcriptional intermediary factor-1 (TIF-1gamma) and nuclear matrix protein NXP-2. Patients with dermatomyositis experience muscle weakness, skin inflammation, and sometimes inflammation of the lung... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 3, 2013 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news
Researchers develop specific tests to identify cancer biomarkers in dermatomyositis
(Wiley) Researchers from major universities in the US have developed specific tests to identify cancer biomarkers in patients with dermatomyositis -- a systemic inflammatory disease associated with increased risk of malignancy. According to study findings published in the American College of Rheumatology journal, Arthritis & Rheumatism, the assays detect antibodies against anti-transcriptional intermediary factor-1 and nuclear matrix protein NXP-2. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 3, 2013 Category: Global & Universal Source Type: news
Juvenile Dermatomyositis May Be Triggered by UV ExposureJuvenile Dermatomyositis May Be Triggered by UV Exposure
Kids with myositis who had high UV exposure the month before symptom onset were more likely to have autoantibodies associated with skin problems; some also were more likely to develop dermatomyositis. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 6, 2013 Category: Consumer Health News Tags: Rheumatology News Source Type: news
Juvenile Dermatomyositis
The diagnosis of juvenile dermatomyositis can be challenging when proximal muscle weakness develops without characteristic skin manifestations. In this patient, rash appeared 2 months after the onset of muscle weakness. The initial diagnosis was viral myositis, which delayed therapy. (Source: Consultant Live)
Source: Consultant Live - June 25, 2013 Category: Primary Care Source Type: news
What Causes Spontaneous Pneumothorax?
Discussion
“A pneumothorax is a collection of air in the pleural space, and it can be categorized into spontaneous, traumatic or iatrogenic. Spontaneous pneumothorax can be further classified into primary with no clinical evidence of underlying lung disease or secondary due to pre-existing lung disease.”
Spontaneous pneumothorax is a condition that is relatively rare in pediatrics. There is a bimodal age distribution – neonates and late adolescence. It is caused by tearing of the visceral pleural. Clinical signs include chest pain, dyspnea, tachycardia, tracheal deviation towards contralateral side, hypo...
Source: PediatricEducation.org - May 20, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news
