VTE Risk High in Autoimmune Muscle Disease

(MedPage Today) -- Patients with the inflammatory myopathies polymyositis and dermatomyositis had markedly elevated risks for venous thromboembolic events, a population-based study in Canada found.
Source: MedPage Today Cardiovascular - Category: Cardiology Source Type: news

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The idiopathic inflammatory myopathies (IIMs) are a group of systemic autoimmune diseases characterised primarily by muscle inflammation but also potentially accompanied by a range of extra-muscular manifestations. Dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM) constitute well-characterised subtypes of IIM, with the entity of non-specific idiopathic inflammatory myopathy (NSIIM) being more recently described [1]. Whilst these IIM subtypes are distinguished on clinical, serological and histological grounds, they are unified by the presence of a typically prominent intramuscular lymphocytic infiltrate.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
CONCLUSION: In this study, secondary HLH was a fatal complication with higher on-admission disease activity, AE-ILD and infection working as risk factors. The underlying role of infection and autoimmune abnormality in HLH in connective tissue disease (CTD) was subsequently brought up. Clinical factors influencing the short-term outcome of patients with secondary HLH required further exploration. PMID: 31575703 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
AbstractPurposeImmune checkpoint inhibitors (ICIs) show promising clinical activity in advanced cancers. However, the safety and efficacy of PD-1/PD-L1 blockade in patients with preexisting antinuclear antibodies (ANA) are unclear.Methods191 patients treated with nivolumab, pembrolizumab, atezolizumab, or durvalumab for unresectable advanced cancers between September 2014 and December 2018 were identified retrospectively. Patients were divided into positive (ANA titers  ≥ 1:160) and negative ANA groups (ANA titers 
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsProgranulin antibodies are frequently present in patients with systemic sclerosis and other autoimmune connective tissue disorders. Despite the lack of specificity for a given autoimmune disease, progranulin antibodies might not only indicate a potential subtype but also play a pathogenic role in patients with autoimmune connective disorders. Given the important role of TNF ‐α in inflammatory processes in autoimmune connective tissue disorders, progranulin antibodies might support the proinflammatory environment by neutralizing the TNF blocker progranulin.
Source: Immunity, Inflammation and Disease - Category: Allergy & Immunology Authors: Tags: ORIGINAL RESEARCH Source Type: research
The anti-Ro52 antibody is found in a number of autoimmune diseases, including Sj ögren’s syndrome (SS), systemic lupus erythematosus, systemic sclerosis and dermatomyositis (DM)/polymyositis (PM). It is most frequently found in SS (37.4-66.7%) and second-most frequently in DM/PM (26.3-31.2%) [1]. It is also one of the most common autoantibodies in inflammatory myopathies and is classified as a myositis-associated antibody (MAA), which is frequently found in PM/DM but not specific for this diagnosis [2,3].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Tags: Letter to the Editor Source Type: research
AbstractIntroduction/objectivesTo assess the effects of exercise training on insulin resistance and β-cell function in patients with systemic autoimmune myopathies (SAMs).MethodThis quasi-experimental, prospective study includes 9 patients with SAMs (six with dermatomyositis, two with antisynthetase syndrome, and one with polymyositis). Patients were submitted to a 12-week, twice a week, exercise training program comprising aerobic and resistance exercises. Baseline and after the intervention, we evaluated disease status, aerobic capacity, muscle strength, body composition, insulin resistance, and β-cell function...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
The idiopathic inflammatory myopathies (IIMs), including polymyositis (PM) and dermatomyositis (DM), are autoimmune connective tissue diseases with variable degrees of muscle inflammation and systemic involvement. Interstitial lung disease (ILD) is a common complication of the IIMs and is associated with increased mortality. Many patients with PM/DM have myositis-specific and myositis-associated antibodies (MSA/MAAs) that result in distinct clinical phenotypes. Among these MSAs, anti-aminoacyl-tRNA antibodies and anti-melanoma differentiation factor 5 antibodies have high rates of ILD. Corticosteroids are the mainstay of t...
Source: Clinics in Chest Medicine - Category: Respiratory Medicine Authors: Source Type: research
This article will review the indications, proposed mechanism of actions, and administration of immunoglobulin treatment in various neuropathies, neuromuscular junction disorders, and myopathies. IVIg may have more than one mechanism of action to alter the pathogenesis of underlying neuromuscular disease. IVIg treatment has been used as a first-line treatment in Guillain–Barre syndrome, chronic inflammatory demyelinating polyradiculoneuropathy, multifocal motor neuropathy, and second-line off-label treatment in medically refractory cases of polymyositis, dermatomyositis, and myasthenia gravis. IVIg is a well-tolerated...
Source: Journal of Clinical Neuromuscular Disease - Category: Neurology Tags: Review Article Source Type: research
Conditions:   SCAD;   Addison Disease;   Ankylosing Spondylitis;   Antiphospholipid Antibody Syndrome;   Celiac Disease;   Crohn Disease;   Dermatomyositis;   Polymyositis;   Guillain-Barre Syndrome;   Hepatitis, Autoimmune;   Graves Disease;   Hashimoto Thyroiditis;   Multiple Sclerosi s;   Myasthenia Gravis;   Pernicious Anemia;   Polymyalgia Rheumatica;   Primary Biliary Cirrhosis;   Psoriasis;   Rheumatoid Arthritis;   Systemic Scle...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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