Big Questions with Xarelto Study
The purpose of this post is to introduce my most recent column over at theHeart.org | Medscape Cardiology in which I address recent concerns about the drug rivaroxaban (Xarelto).
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In 2014, Rivaroxaban (Xarelto) was the most prescribed new oral anticoagulant (NOAC). Millions of patients have atrial fibrillation, so it’s fair to call it a blockbuster drug.
Recently, however, concerns have arisen about the validity of the results of the pivotal trial, called ROCKET-AF, that led to FDA approval. Recall that in the 14,000-patient-strong multicenter ROCKET-AF trial, rivaroxaban was found to be noninferior to warfari...
Source: Dr John M - February 10, 2016 Category: Cardiology Authors: Dr John Source Type: blogs
DM / DNB Cardiology Entrance Mock Test 14
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Source: Cardiophile MD - February 7, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Featured Source Type: blogs
Research and Reviews in the Fastlane 120
Welcome to the 120th edition of Research and Reviews in the Fastlane. R&R in the Fastlane is a free resource that harnesses the power of social media to allow some of the best and brightest emergency medicine and critical care clinicians from all over the world tell us what they think is worth reading from the published literature.
This edition contains 6 recommended reads. The R&R Editorial Team includes Jeremy Fried, Nudrat Rashid, Soren Rudolph, Anand Swaminathan and, of course, Chris Nickson. Find more R&R in the Fastlane reviews in the R&R Archive, read more about the R&R project or check ou...
Source: Life in the Fast Lane - February 3, 2016 Category: Emergency Medicine Authors: Soren Rudolph Tags: Anaesthetics Clinical Research Education General Surgery Ophthalmology Pediatrics Pharmacology Pre-hospital / Retrieval R&R in the FASTLANE Resuscitation Trauma critical care emergency Emergency Medicine recommendations resea Source Type: blogs
Fatty meals and sticky platelets : A new trigger for ACS ?
Every time , patients ask me what diet he or she should follow , Iam sort of amused , as my understanding of diet and cardio vascular disease is at best primitive.I used go with a standard single phrase advice “Anything in moderate should be okay “
What about going for a saturday night party doctor? One of my shrewd looking patient who was recently double stented with DES , asked.
Human body is a biological marvel.While medical professional divide it into various systems for our convenience. God doesn’t think that way .He has no systems in mind when the body was designed . There is...
Source: Dr.S.Venkatesan MD - January 31, 2016 Category: Cardiology Authors: dr s venkatesan Tags: acute coronary syndrome atherosclerosis platelet function platelet adhesion and aggrgation and fatty meal briyani platelet stickyness and dietery fat platlet anf fat ldl and triglycerides tgl mediated platlet aggregation Source Type: blogs
DM / DNB Cardiology Entrance Mock Test 6
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Click on the 'Start' button to begin the mock test. After answering all questions, click on the 'Get Results' button to display your score and the explanations. There is no time limit for this mock test.
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Congratulations - you have completed DM / DNB Cardiology Entrance Mock Test 6.
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Source: Cardiophile MD - January 22, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Research and Reviews in the Fastlane 118
This study provides validation of that approach. Although the study was retrospective and only included 45 patients with acute coronary occlusion, it provides valuable information on the utility of ST elevation/S wave ratio for diagnosis of acute MI in this subset of patients.
Recommended by: Anand Swaminathan
Pediatrics
Study of Maternal and Child Kissing (SMACK) Working Group. Maternal kisses are not effective in alleviating minor childhood injuries (boo-boos): a randomized, controlled and blinded study. J Eval Clin Pract 2015. PMID: 26711672
This is kind of interesting in many ways, it appears that the paper was...
Source: Life in the Fast Lane - January 21, 2016 Category: Emergency Medicine Authors: Jeremy Fried Tags: Airway Anaesthetics Cardiology Clinical Research Education Emergency Medicine Haematology Intensive Care Pediatrics R&R in the FASTLANE Respiratory critical care EBM recommendations research and reviews Resuscitation Source Type: blogs
DM / DNB Cardiology Entrance Mock Test 4
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Click on the 'Start' button to begin the mock test. After answering all questions, click on the 'Get Results' button to display your score and the explanations. There is no time limit for this mock test.
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Congratulations - you have completed DM / DNB Cardiology Entrance Mock Test 4.
You scored %%SCORE%% out of %%TOTAL%%.
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Source: Cardiophile MD - January 18, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Featured Source Type: blogs
DM / DNB Cardiology Entrance Mock Test 2
This study reported 32 arrhythmic episodes in 24 patients. There was spontaneous recovery with abstinence from alcohol.
Reference
1. Ettinger PO, Wu CF, De La Cruz C Jr, Weisse AB, Ahmed SS, Regan TJ. Arrhythmias and the “Holiday Heart”: alcohol-associated cardiac rhythm disorders. Am Heart J. 1978 May;95(5):555-62.Question 14Diagnosis based on the echocardiogram:
AEbstein’s anomaly of tricuspid valveBNone of the aboveCEndomyocardial fibrosisDIdiopathic dilatation of right atriumQuestion 14 Explanation: Endomyocardial Fibrosis (EMF) is a type of restrictive cardiomyopathy. It is characterised by fibros...
Source: Cardiophile MD - January 16, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Featured Source Type: blogs
What Do We Know About Medical Errors Associated With Electronic Medical Records?
By ROSS KOPPEL
Recently, the Journal of Patient Safety published a powerful and important article on the role of EHRs in patient harm, errors and malpractice claims. The article is open access. Electronic Health Record–Related Events in Medical Malpractice Claims by Mark L. Graber, Dana Siegal, Heather Riah, Doug Johnston, and Kathy Kenyon.
The article is remarkable for several reasons:
Considerably over 80% of the reported errors involve horrific patient harm: many deaths, strokes, missed and significantly delayed cancer diagnoses, massive hemorrhage, 10-fold overdoses, ignored or lost critical lab results, ...
Source: The Health Care Blog - January 11, 2016 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs
ROCKET-AF Investigators Seek To Calm Concerns About Trial Reliability
In response to disturbing questions about the integrity and reliability of crucial data in the ROCKET AF trial, the executive committee of the trial has released a statement saying that they have “conducted a secondary analysis of the trial findings” and that “the findings from the analysis are consistent with the results from the original trial and do not...Click here to continue reading... (Source: CardioBrief)
Source: CardioBrief - December 14, 2015 Category: Cardiology Authors: Larry Husten Tags: People, Places & Events Policy & Ethics warfarin rivaroxaban Xarelto Califf ROCKET-AF INR Source Type: blogs
New Questions Raised About ROCKET AF, Pivotal Xarelto Trial Chaired By Califf
Disturbing questions are being raised about the integrity and reliability of crucial data in the ROCKET AF trial. The investigation could have important implications on several fronts. First, the trial serves as the basis for the use of the blockbuster drug rivaroxaban (Xarelto, Johnson & Johnson) for stroke prevention in atrial fibrillation. Second, the trial...Click here to continue reading... (Source: CardioBrief)
Source: CardioBrief - December 1, 2015 Category: Cardiology Authors: Larry Husten Tags: Heart Rhythms People, Places & Events Policy & Ethics Califf EMA FDA rivaroxaban warfarin Xarelto Source Type: blogs
Sulodexide
Brief Review
Abstract: Sulodexide is a glycosaminoglycan with antithrombotic properties. The future role of sulodexide is possibly as an agent to prevent recurrent venous thromboembolism in those at higher risk of bleeding with warfarin and novel oral anticoagulants (NOACS).
Sulodexide is a glycosaminoglycan with antithrombotic properties. It corresponds to a mixture of heparin and dermatan sulfate having profibrinolytic properties and anti-inflammatory activity demonstrated in vitro [1]. Sulodexide has anti oxidant and anti glucotoxic effects which make it potentially beneficial in the treatment of diabetic kidney di...
Source: Cardiophile MD - November 17, 2015 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: General Cardiology antithrombotic glycosaminoglycan SURVET Study Source Type: blogs
Reality Check: After Starting Warfarin One In Five Older Vets Hospitalized For Bleeding
A new study presented at the American Heart Association meeting in Orlando finds that more than one in five elderly US veterans are hospitalized for bleeding after starting warfarin. This high rate of serious bleeding complications in a real world setting surprised and even disturbed the study authors. Anticoagulants are the proverbial double-edged sword. Striking the right balance between benefit...Click here to continue reading... (Source: CardioBrief)
Source: CardioBrief - November 10, 2015 Category: Cardiology Authors: Larry Husten Tags: Heart Rhythms People, Places & Events Policy & Ethics Prevention, Epidemiology & Outcomes anticoagulants atrial fibrillation bleeding NOAC VA warfarin Source Type: blogs
Anticoagulation in prosthetic valve – Cardiology MCQ
Current recommended anticoagulant for those with prosthetic valve:
a) Dabigatran
b) Apixaban
c) Warfarin
d) None of the above
Correct answer: c) Warfarin
Though the novel oral anticoagulants (NOAC) have a lower risk of intracranial bleeding than warfarin, they have not yet been approved for use in those with prosthetic heart valves. The very long term safety in this context is not known for want of very long term studies in such scenario. As of date warfarin is still the recommendation of choice in those with prosthetic heart valves.
The post Anticoagulation in prosthetic valve – Cardiology MCQ appeared first on Card...
Source: Cardiophile MD - October 20, 2015 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Dee freed of sleep apnea, restless legs, joint pains, and A. fib
Dee provided photos and a detailed description of her Wheat Belly journey, an excellent example of how this lifestyle is not just a matter of cutting calories or carbs:
“My body betrayed me, at least that’s how I felt. I later learned that I’m the one who betrayed my body. No matter what I tried, I couldn’t lose weight and keep it off. Even if I could keep them at bay for 3-4 months, the cravings always won and I’d stay in my cycle of lose, gain back all that I lost plus more. The weight wasn’t the worst of it, though I’m certain it contributed to my misery.
“Sleep has always been elusive for me. Al...
Source: Wheat Belly Blog - October 20, 2015 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Success Stories a fib allergy facial change gluten grains joint pain skin health Weight Loss Source Type: blogs
