Shortage of nurses in Spain: from the global case to particular situation. SESPAS Report 2024
Gac Sanit. 2024 Mar 19:S0213-9111(24)00023-2. doi: 10.1016/j.gaceta.2024.102376. Online ahead of print.ABSTRACTThe nursing shortage is a multi-causal phenomenon that affects all countries and currently a global concern. The shortage of nurses jeopardizes the sustainability of health systems and the population health outcomes. Spain has historically had no difficulties in attracting new generations of nurses. The shortage of nurses is caused by the precarious working conditions and lack of professional development that have led to episodes of high international migration and abandonment of the profession. In this paper we f...
Source: Gaceta Sanitaria - April 10, 2024 Category: International Medicine & Public Health Authors: Paola Galbany-Estragu és Pere Mill án-Martínez Source Type: research
Type selective ablation of postnatal slow and fast fatigue-resistant motor neurons in mice induces late onset kinetic and postural tremor following fiber-type transition and myopathy
Exp Neurol. 2024 Apr 8:114772. doi: 10.1016/j.expneurol.2024.114772. Online ahead of print.ABSTRACTAnimals on Earth need to hold postures and execute a series of movements under gravity and atmospheric pressure. VAChT-Cre is a transgenic Cre driver mouse line that expresses Cre recombinase selectively in motor neurons of S-type (slow-twitch fatigue-resistant) and FR-type (fast-twitch fatigue-resistant). Sequential motor unit recruitment is a fundamental principle for fine and smooth locomotion; smaller-diameter motor neurons (S-type, FR-type) first contract low-intensity oxidative type I and type IIa muscle fibers, and the...
Source: Experimental Neurology - April 10, 2024 Category: Neurology Authors: Hidemi Misawa Kai Kamishima Tenkei Koyama Lisa Ohgaki Yuta Morisaki Tomoyuki Yamanaka Shigeyoshi Itohara Shoko Sawano Wataru Mizunoya Naomichi Ogihara Source Type: research
Drug review process advancement and required manufacturer and contract research oraganization responses
J Toxicol Pathol. 2024 Apr;37(2):45-53. doi: 10.1293/tox.2023-0106. Epub 2023 Nov 22.ABSTRACTThe United States Senate passed the "FDA Modernization Act 2.0." on September 29, 2022. Although the effectiveness of this Bill, which aims to eliminate the mandatory use of laboratory animals in new drug development, is limited, it represents a significant trend that will change the shape of drug applications in the United States and other countries. However, pharmaceutical companies have not taken major steps towards the complete elimination of animal testing from the standpoint of product safety, where they prioritize patient sa...
Source: Journal of Toxicologic Pathology - April 8, 2024 Category: Toxicology Authors: Takayuki Anzai Glenn J Myatt Frances Hall Brenda Finney Kenshi Nakagawa Hijiri Iwata Reo Anzai Anne Dickinson Matthew Freer Dai Nakae Hiroshi Onodera Takaaki Matsuyama Source Type: research
