Small molecule drug metabolite synthesis and identification: why, when and how?
Drug Discov Today. 2024 Mar 5:103943. doi: 10.1016/j.drudis.2024.103943. Online ahead of print.ABSTRACTThe drug discovery and development process encompasses the interrogation of metabolites arising from the biotransformation of drugs. Here we look at why, when and how metabolites of small-molecule drugs are synthesised from the perspective of a specialist contract research organisation, with particular attention paid to projects for which regulatory oversight is relevant during this journey. To illustrate important aspects, we look at recent case studies, trends and learnings from our experience of making and identifying ...
Source: Drug Discovery Today - March 7, 2024 Category: Drugs & Pharmacology Authors: Julia Shanu-Wilson Samuel Coe Liam Evans Jonathan Steele Stephen Wrigley Source Type: research
Overview of the current situation of embryo donation in Belgian fertility centers
Embryo donation (ED) has been legally regulated in Belgium since 2007. The 2007 law on medically assisted reproduction regulates the various aspects of medically assisted reproduction, including the donation of gametes and supernumerary embryos [1]. After a cryopreservation period of maximum five years, patients have three options when they no longer wish to keep their embryos for their own reproduction, i.e. destruction, donation for research or donation to another patient or couple. This decision is included in a written contract between the patient(s) and the fertility center, which is signed before starting the treatme...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - March 3, 2024 Category: OBGYN Authors: Rita Puga-Leal, Guido Pennings, Herman Tournaye Tags: Full length article Source Type: research
Characterization of lncRNA and mRNA profiles in ciliary body in experimental myopia
Exp Eye Res. 2024 Feb 29:109849. doi: 10.1016/j.exer.2024.109849. Online ahead of print.ABSTRACTCurrently, researchers have mainly focused on the role of the tissues of the posterior segment of the eyes in the development of myopia. However, the ciliary body, an anterior ocular tissue that contracts to initiate the process of accommodation, may also play an important role in the progression of myopia due to the increased demand for near work. In the present study, we established a lens-induced myopia (LIM) animal model in guinea pigs and investigated the molecular changes in the ciliary body associated with the development...
Source: Experimental Eye Research - March 2, 2024 Category: Opthalmology Authors: Shanshan Wu Jiawen Hao Dadong Guo Zhongyu Ma Qiuxin Wu Ming Zhang Hongsheng Bi Source Type: research
Characterization of lncRNA and mRNA profiles in ciliary body in experimental myopia
Exp Eye Res. 2024 Feb 29:109849. doi: 10.1016/j.exer.2024.109849. Online ahead of print.ABSTRACTCurrently, researchers have mainly focused on the role of the tissues of the posterior segment of the eyes in the development of myopia. However, the ciliary body, an anterior ocular tissue that contracts to initiate the process of accommodation, may also play an important role in the progression of myopia due to the increased demand for near work. In the present study, we established a lens-induced myopia (LIM) animal model in guinea pigs and investigated the molecular changes in the ciliary body associated with the development...
Source: Experimental Eye Research - March 2, 2024 Category: Opthalmology Authors: Shanshan Wu Jiawen Hao Dadong Guo Zhongyu Ma Qiuxin Wu Ming Zhang Hongsheng Bi Source Type: research
Characterization of lncRNA and mRNA profiles in ciliary body in experimental myopia
Exp Eye Res. 2024 Feb 29;241:109849. doi: 10.1016/j.exer.2024.109849. Online ahead of print.ABSTRACTCurrently, researchers have mainly focused on the role of the tissues of the posterior segment of the eyes in the development of myopia. However, the ciliary body, an anterior ocular tissue that contracts to initiate the process of accommodation, may also play an important role in the progression of myopia due to the increased demand for near work. In the present study, we established a lens-induced myopia (LIM) animal model in guinea pigs and investigated the molecular changes in the ciliary body associated with the develop...
Source: Experimental Eye Research - March 2, 2024 Category: Opthalmology Authors: Shanshan Wu Jiawen Hao Dadong Guo Zhongyu Ma Qiuxin Wu Ming Zhang Hongsheng Bi Source Type: research
Profile and career path of graduates from the Oswaldo Cruz Foundation master's and doctoral courses (2013-2020)
This study aims to analyze the profile of graduates and identify factors associated with positive performance regarding training and professional insertion among those who have completed face-to-face master's and doctoral courses at the Oswaldo Cruz Foundation (Brazil). A total of 2,462 graduates participated in the study (1,402 master's and 1,060 doctoral graduates), who answered a digital questionnaire containing questions about individual characteristics and professional insertion before entering the course and after completion. A measure on "positive post-course performance" was created. The results show that Master's ...
Source: Cadernos de Saude Publica - February 29, 2024 Category: International Medicine & Public Health Authors: Suely Deslandes Joviana Quintes Avanci Pina Liana Wernersbach Pinto Isabella Fernandes Delgado Cosme Marcelo Furtado Passos da Silva Source Type: research
Profile and career path of graduates from the Oswaldo Cruz Foundation master's and doctoral courses (2013-2020)
This study aims to analyze the profile of graduates and identify factors associated with positive performance regarding training and professional insertion among those who have completed face-to-face master's and doctoral courses at the Oswaldo Cruz Foundation (Brazil). A total of 2,462 graduates participated in the study (1,402 master's and 1,060 doctoral graduates), who answered a digital questionnaire containing questions about individual characteristics and professional insertion before entering the course and after completion. A measure on "positive post-course performance" was created. The results show that Master's ...
Source: Cadernos de Saude Publica - February 29, 2024 Category: International Medicine & Public Health Authors: Suely Deslandes Joviana Quintes Avanci Pina Liana Wernersbach Pinto Isabella Fernandes Delgado Cosme Marcelo Furtado Passos da Silva Source Type: research
Profile and career path of graduates from the Oswaldo Cruz Foundation master's and doctoral courses (2013-2020)
This study aims to analyze the profile of graduates and identify factors associated with positive performance regarding training and professional insertion among those who have completed face-to-face master's and doctoral courses at the Oswaldo Cruz Foundation (Brazil). A total of 2,462 graduates participated in the study (1,402 master's and 1,060 doctoral graduates), who answered a digital questionnaire containing questions about individual characteristics and professional insertion before entering the course and after completion. A measure on "positive post-course performance" was created. The results show that Master's ...
Source: Cadernos de Saude Publica - February 29, 2024 Category: International Medicine & Public Health Authors: Suely Deslandes Joviana Quintes Avanci Pina Liana Wernersbach Pinto Isabella Fernandes Delgado Cosme Marcelo Furtado Passos da Silva Source Type: research
Profile and career path of graduates from the Oswaldo Cruz Foundation master's and doctoral courses (2013-2020)
This study aims to analyze the profile of graduates and identify factors associated with positive performance regarding training and professional insertion among those who have completed face-to-face master's and doctoral courses at the Oswaldo Cruz Foundation (Brazil). A total of 2,462 graduates participated in the study (1,402 master's and 1,060 doctoral graduates), who answered a digital questionnaire containing questions about individual characteristics and professional insertion before entering the course and after completion. A measure on "positive post-course performance" was created. The results show that Master's ...
Source: Cadernos de Saude Publica - February 29, 2024 Category: International Medicine & Public Health Authors: Suely Deslandes Joviana Quintes Avanci Pina Liana Wernersbach Pinto Isabella Fernandes Delgado Cosme Marcelo Furtado Passos da Silva Source Type: research
Profile and career path of graduates from the Oswaldo Cruz Foundation master's and doctoral courses (2013-2020)
This study aims to analyze the profile of graduates and identify factors associated with positive performance regarding training and professional insertion among those who have completed face-to-face master's and doctoral courses at the Oswaldo Cruz Foundation (Brazil). A total of 2,462 graduates participated in the study (1,402 master's and 1,060 doctoral graduates), who answered a digital questionnaire containing questions about individual characteristics and professional insertion before entering the course and after completion. A measure on "positive post-course performance" was created. The results show that Master's ...
Source: Cadernos de Saude Publica - February 29, 2024 Category: International Medicine & Public Health Authors: Suely Deslandes Joviana Quintes Avanci Pina Liana Wernersbach Pinto Isabella Fernandes Delgado Cosme Marcelo Furtado Passos da Silva Source Type: research
Profile and career path of graduates from the Oswaldo Cruz Foundation master's and doctoral courses (2013-2020)
This study aims to analyze the profile of graduates and identify factors associated with positive performance regarding training and professional insertion among those who have completed face-to-face master's and doctoral courses at the Oswaldo Cruz Foundation (Brazil). A total of 2,462 graduates participated in the study (1,402 master's and 1,060 doctoral graduates), who answered a digital questionnaire containing questions about individual characteristics and professional insertion before entering the course and after completion. A measure on "positive post-course performance" was created. The results show that Master's ...
Source: Cadernos de Saude Publica - February 29, 2024 Category: International Medicine & Public Health Authors: Suely Deslandes Joviana Quintes Avanci Pina Liana Wernersbach Pinto Isabella Fernandes Delgado Cosme Marcelo Furtado Passos da Silva Source Type: research
Profile and career path of graduates from the Oswaldo Cruz Foundation master's and doctoral courses (2013-2020)
This study aims to analyze the profile of graduates and identify factors associated with positive performance regarding training and professional insertion among those who have completed face-to-face master's and doctoral courses at the Oswaldo Cruz Foundation (Brazil). A total of 2,462 graduates participated in the study (1,402 master's and 1,060 doctoral graduates), who answered a digital questionnaire containing questions about individual characteristics and professional insertion before entering the course and after completion. A measure on "positive post-course performance" was created. The results show that Master's ...
Source: Cadernos de Saude Publica - February 29, 2024 Category: International Medicine & Public Health Authors: Suely Deslandes Joviana Quintes Avanci Pina Liana Wernersbach Pinto Isabella Fernandes Delgado Cosme Marcelo Furtado Passos da Silva Source Type: research
Profile and career path of graduates from the Oswaldo Cruz Foundation master's and doctoral courses (2013-2020)
This study aims to analyze the profile of graduates and identify factors associated with positive performance regarding training and professional insertion among those who have completed face-to-face master's and doctoral courses at the Oswaldo Cruz Foundation (Brazil). A total of 2,462 graduates participated in the study (1,402 master's and 1,060 doctoral graduates), who answered a digital questionnaire containing questions about individual characteristics and professional insertion before entering the course and after completion. A measure on "positive post-course performance" was created. The results show that Master's ...
Source: Cadernos de Saude Publica - February 29, 2024 Category: International Medicine & Public Health Authors: Suely Deslandes Joviana Quintes Avanci Pina Liana Wernersbach Pinto Isabella Fernandes Delgado Cosme Marcelo Furtado Passos da Silva Source Type: research
Profile and career path of graduates from the Oswaldo Cruz Foundation master's and doctoral courses (2013-2020)
This study aims to analyze the profile of graduates and identify factors associated with positive performance regarding training and professional insertion among those who have completed face-to-face master's and doctoral courses at the Oswaldo Cruz Foundation (Brazil). A total of 2,462 graduates participated in the study (1,402 master's and 1,060 doctoral graduates), who answered a digital questionnaire containing questions about individual characteristics and professional insertion before entering the course and after completion. A measure on "positive post-course performance" was created. The results show that Master's ...
Source: Cadernos de Saude Publica - February 29, 2024 Category: International Medicine & Public Health Authors: Suely Deslandes Joviana Quintes Avanci Pina Liana Wernersbach Pinto Isabella Fernandes Delgado Cosme Marcelo Furtado Passos da Silva Source Type: research
Profile and career path of graduates from the Oswaldo Cruz Foundation master's and doctoral courses (2013-2020)
This study aims to analyze the profile of graduates and identify factors associated with positive performance regarding training and professional insertion among those who have completed face-to-face master's and doctoral courses at the Oswaldo Cruz Foundation (Brazil). A total of 2,462 graduates participated in the study (1,402 master's and 1,060 doctoral graduates), who answered a digital questionnaire containing questions about individual characteristics and professional insertion before entering the course and after completion. A measure on "positive post-course performance" was created. The results show that Master's ...
Source: Cadernos de Saude Publica - February 29, 2024 Category: International Medicine & Public Health Authors: Suely Deslandes Joviana Quintes Avanci Pina Liana Wernersbach Pinto Isabella Fernandes Delgado Cosme Marcelo Furtado Passos da Silva Source Type: research
