Next-generation strategies to improve safety and efficacy of adeno-associated virus-based gene therapy for hemophilia: lessons from clinical trials in other gene therapies
Haematologica. 2024 Mar 7. doi: 10.3324/haematol.2023.284622. Online ahead of print.ABSTRACTThree major directions for the global progress of adeno-associated virus (AAV) vectors for gene therapies (GT) are analyzed: a) engineering vectors to increase transgene expression; b) aligning interests of the health system with costs and challenges for pharmaceutical industry; c) refining patient eligibility criteria, and endpoints definition. Currently employed AAV vectors may cause toxicity and adverse events. Furthermore, studies in animals do not fully predict risks and clinical benefits of AAV-based GT, and animal models refl...
Source: Haematologica - March 7, 2024 Category: Hematology Authors: Giovanni Di Minno Wolfgang Miesbach Giancarlo Castaman Flora Peyvandi Source Type: research
Cross-sectional analysis of cardiovascular disease and risk factors in patients with spondyloarthritis: a real-life evidence from biostar nationwide registry
This study aimed to assess the prevalence rates of CV diseases and to analyze the impact of CV risk factors on CV disease in patients with spondyloarthritis. A multi-center cross-sectional study using the BioSTAR (Biological and Targeted Synthetic Disease-Modifying Antirheumatic Drugs Registry) database was performed on patients with spondyloarthritis. Socio-demographic, laboratory, and clinical data were collected. Patients with and without major adve rse cardiovascular events (MACE) were grouped as Group 1 and Group 2. The primary outcome was the overall group’s prevalence rates of CV disease and CV risk factors. Th...
Source: Rheumatology International - March 5, 2024 Category: Rheumatology Source Type: research
Electro-anatomically-guided endomyocardial biopsy in a patient with focal myocardial infiltration and chronic lymphocytic leukemia
J Invasive Cardiol. 2024 Mar;36(3). doi: 10.25270/jic/23.00222.ABSTRACTA 53-year-old female was admitted to the cardiology department on account of signs and symptoms of congestive heart failure (HF) with severe peripheral edema and dyspnea on exertion (New York Heart Association class III) for the past 3 months.PMID:38441994 | DOI:10.25270/jic/23.00222 (Source: The Journal of Invasive Cardiology)
Source: The Journal of Invasive Cardiology - March 5, 2024 Category: Cardiology Authors: Maciej T Wybraniec Marek Grabka Andrzej Hoffmann Romuald Wojnicz Katarzyna Mizia-Stec Source Type: research
Associations of asthma control with hypertension, cardiovascular disease, and mortality in obese individuals
The objective of this study was to assess the associations of asthma control with hypertension, cardiovascular disease, and mortality in obese individuals. We used data from the National Health and Nutrition Examination Survey (NHANES), 2001 –2018. Weighted logistic regression analyses and Cox proportional hazard models were performed to evaluate the influence of asthma control on hypertension, cardiovascular disease, and mortality. A total of 2744 obese participants were included. Of them, 937 participants had poorly controlled ast hma, 873 had well-controlled asthma, and 934 did not have asthma. We found that poorly ...
Source: Internal and Emergency Medicine - March 5, 2024 Category: Emergency Medicine Source Type: research
Epicardial left atrial appendage clipping versus direct oral anticoagulant to reduce stroke risk in non-paroxysmal atrial fibrillation (LAA-CLIP): rationale, design and study protocol for a multicentre randomised controlled trial
Introduction
The prevalence of atrial fibrillation (AF) is increasing globally, and stroke prevention is the key to reduce the morbidity and mortality related to AF. Currently, direct oral anticoagulants (DOACs) are the primary options for stroke prevention, while it increases risk of bleeding. Left atrial appendage (LAA) is suspected as a vital source of cerebral emboli and may lead to ischaemic stroke, and thoracoscopic LAA clipping procedure provides an alternative option for stroke prevention in high-risk patients. However, high-quality evidence comparing LAA clipping to DOACs in terms of stroke prevention is lacking. ...
Source: BMJ Open - March 5, 2024 Category: General Medicine Authors: Yu, C., Li, H., Lei, C., Wang, Y., Chen, S., Zhao, Y., Zheng, Z. Tags: Open access, Cardiovascular medicine Source Type: research
Associations of asthma control with hypertension, cardiovascular disease, and mortality in obese individuals
The objective of this study was to assess the associations of asthma control with hypertension, cardiovascular disease, and mortality in obese individuals. We used data from the National Health and Nutrition Examination Survey (NHANES), 2001 –2018. Weighted logistic regression analyses and Cox proportional hazard models were performed to evaluate the influence of asthma control on hypertension, cardiovascular disease, and mortality. A total of 2744 obese participants were included. Of them, 937 participants had poorly controlled ast hma, 873 had well-controlled asthma, and 934 did not have asthma. We found that poorly ...
Source: Internal and Emergency Medicine - March 5, 2024 Category: Emergency Medicine Source Type: research
Ventilatory Responses to Exercise by Age, Sex, and Health Status
Curr Sports Med Rep. 2024 Mar 1;23(3):79-85. doi: 10.1249/JSR.0000000000001149.ABSTRACTAn understanding of the normal pulmonary responses to incremental exercise is requisite for appropriate interpretation of findings from clinical exercise testing. The purpose of this review is to provide concrete information to aid the interpretation of the exercise ventilatory response in both healthy and diseased populations. We begin with an overview of the normal exercise ventilatory response to incremental exercise in the healthy, normally trained young-to-middle aged adult male. The exercise ventilatory responses in two nonpatient ...
Source: Current Sports Medicine Reports - March 4, 2024 Category: Sports Medicine Authors: Hans Christian Haverkamp Bryce N Balmain Source Type: research
Ventilatory Responses to Exercise by Age, Sex, and Health Status
Curr Sports Med Rep. 2024 Mar 1;23(3):79-85. doi: 10.1249/JSR.0000000000001149.ABSTRACTAn understanding of the normal pulmonary responses to incremental exercise is requisite for appropriate interpretation of findings from clinical exercise testing. The purpose of this review is to provide concrete information to aid the interpretation of the exercise ventilatory response in both healthy and diseased populations. We begin with an overview of the normal exercise ventilatory response to incremental exercise in the healthy, normally trained young-to-middle aged adult male. The exercise ventilatory responses in two nonpatient ...
Source: Current Sports Medicine Reports - March 4, 2024 Category: Sports Medicine Authors: Hans Christian Haverkamp Bryce N Balmain Source Type: research
Ventilatory Responses to Exercise by Age, Sex, and Health Status
Curr Sports Med Rep. 2024 Mar 1;23(3):79-85. doi: 10.1249/JSR.0000000000001149.ABSTRACTAn understanding of the normal pulmonary responses to incremental exercise is requisite for appropriate interpretation of findings from clinical exercise testing. The purpose of this review is to provide concrete information to aid the interpretation of the exercise ventilatory response in both healthy and diseased populations. We begin with an overview of the normal exercise ventilatory response to incremental exercise in the healthy, normally trained young-to-middle aged adult male. The exercise ventilatory responses in two nonpatient ...
Source: Current Sports Medicine Reports - March 4, 2024 Category: Sports Medicine Authors: Hans Christian Haverkamp Bryce N Balmain Source Type: research
Ventilatory Responses to Exercise by Age, Sex, and Health Status
Curr Sports Med Rep. 2024 Mar 1;23(3):79-85. doi: 10.1249/JSR.0000000000001149.ABSTRACTAn understanding of the normal pulmonary responses to incremental exercise is requisite for appropriate interpretation of findings from clinical exercise testing. The purpose of this review is to provide concrete information to aid the interpretation of the exercise ventilatory response in both healthy and diseased populations. We begin with an overview of the normal exercise ventilatory response to incremental exercise in the healthy, normally trained young-to-middle aged adult male. The exercise ventilatory responses in two nonpatient ...
Source: Current Sports Medicine Reports - March 4, 2024 Category: Sports Medicine Authors: Hans Christian Haverkamp Bryce N Balmain Source Type: research
Ventilatory Responses to Exercise by Age, Sex, and Health Status
Curr Sports Med Rep. 2024 Mar 1;23(3):79-85. doi: 10.1249/JSR.0000000000001149.ABSTRACTAn understanding of the normal pulmonary responses to incremental exercise is requisite for appropriate interpretation of findings from clinical exercise testing. The purpose of this review is to provide concrete information to aid the interpretation of the exercise ventilatory response in both healthy and diseased populations. We begin with an overview of the normal exercise ventilatory response to incremental exercise in the healthy, normally trained young-to-middle aged adult male. The exercise ventilatory responses in two nonpatient ...
Source: Current Sports Medicine Reports - March 4, 2024 Category: Sports Medicine Authors: Hans Christian Haverkamp Bryce N Balmain Source Type: research
Ventilatory Responses to Exercise by Age, Sex, and Health Status
Curr Sports Med Rep. 2024 Mar 1;23(3):79-85. doi: 10.1249/JSR.0000000000001149.ABSTRACTAn understanding of the normal pulmonary responses to incremental exercise is requisite for appropriate interpretation of findings from clinical exercise testing. The purpose of this review is to provide concrete information to aid the interpretation of the exercise ventilatory response in both healthy and diseased populations. We begin with an overview of the normal exercise ventilatory response to incremental exercise in the healthy, normally trained young-to-middle aged adult male. The exercise ventilatory responses in two nonpatient ...
Source: Current Sports Medicine Reports - March 4, 2024 Category: Sports Medicine Authors: Hans Christian Haverkamp Bryce N Balmain Source Type: research
Ventilatory Responses to Exercise by Age, Sex, and Health Status
Curr Sports Med Rep. 2024 Mar 1;23(3):79-85. doi: 10.1249/JSR.0000000000001149.ABSTRACTAn understanding of the normal pulmonary responses to incremental exercise is requisite for appropriate interpretation of findings from clinical exercise testing. The purpose of this review is to provide concrete information to aid the interpretation of the exercise ventilatory response in both healthy and diseased populations. We begin with an overview of the normal exercise ventilatory response to incremental exercise in the healthy, normally trained young-to-middle aged adult male. The exercise ventilatory responses in two nonpatient ...
Source: Current Sports Medicine Reports - March 4, 2024 Category: Sports Medicine Authors: Hans Christian Haverkamp Bryce N Balmain Source Type: research
Ventilatory Responses to Exercise by Age, Sex, and Health Status
Curr Sports Med Rep. 2024 Mar 1;23(3):79-85. doi: 10.1249/JSR.0000000000001149.ABSTRACTAn understanding of the normal pulmonary responses to incremental exercise is requisite for appropriate interpretation of findings from clinical exercise testing. The purpose of this review is to provide concrete information to aid the interpretation of the exercise ventilatory response in both healthy and diseased populations. We begin with an overview of the normal exercise ventilatory response to incremental exercise in the healthy, normally trained young-to-middle aged adult male. The exercise ventilatory responses in two nonpatient ...
Source: Current Sports Medicine Reports - March 4, 2024 Category: Sports Medicine Authors: Hans Christian Haverkamp Bryce N Balmain Source Type: research
