Libella Gene Therapeutics to Run a Patient Paid Trial of Telomerase Gene Therapy
After Bioviva Science, Libella Gene Therapeutics is the second company to take a run at commercializing telomerase gene therapy treatments for human use. Telomerase is the enzyme responsible for lengthening telomeres, repeated DNA sequences at the ends of chromosomes, though it may have other roles. Telomeres are a part of the mechanism that limits the number of times that a somatic cell can replicate. Telomeres shorten with each cell division, and when too short they trigger programmed cell death or cellular senescence followed by destruction by the immune system. Ordinary somatic cells in humans do not express telomerase...
Source: Fight Aging! - November 22, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, October 28th 2019
In this study, the enhanced mice live somewhat longer than their unmodified peers, though not as much longer as is the case for the application of telomerase gene therapy. The mice do also exhibit reduced cancer risk, however. The scientists here class telomere shortening as a cause of aging, which is not a point universally agreed upon. Reductions in average telomere length in tissues looks much more like a downstream consequence of reduced stem cell activity than an independent mechanism.
Researchers obtain the first mice born with hyper-long telomeres and show that it is possible to extend life without any geneti...
Source: Fight Aging! - October 27, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Libella Gene Thereapeutics Moving Ahead with a Small Phase 1 Trial of Telomerase Gene Therapy
Libella Gene Therapeutics is developing telomerase gene therapy as a clinical treatment, work that results from more than a decade of studies in mice that show extended life, reduced cancer risk, and improved health. Telomerase acts to lengthen telomeres, the repeated DNA sequences at the ends of chromosomes that shorten with each cell division. Average telomere length in the somatic cells making up any given tissue is a function of the rate of cell division versus the pace at which stem cells produce new daughter somatic cells with long telomeres. Since stem cell activity declines with age, it is no surprise to see telome...
Source: Fight Aging! - October 24, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Advance Directives for Euthanasia and VSED
Many patients want to avoid living in the late stages of dementia. For example, Margot Bentley tried to avoid living in advanced dementia with an advance directive that refused hand feeding. But the British Colombia court ruled that her present swallow... (Source: blog.bioethics.net)
Source: blog.bioethics.net - August 29, 2019 Category: Medical Ethics Authors: Thaddeus Mason Pope, JD, PhD Tags: Health Care syndicated Source Type: blogs
School Choice Increases Earnings in Colombia
There ’s an ongoing debate about how we should evaluate the effectiveness of school choice policies. Last month, two education professorsarguedthat standardized test scores should be “the measure of success.”Othereducation researchers–includingmyself– contend that we should take a more holistic approach by looking at other relevant long-term outcomes as well. After all, schools can do so much more than shape test scores. Here’s a case in point.Ajust-released evaluation found that a school choice program Colombia improved vital long-run outcomes up to 20 years after students applied for private school vouchers i...
Source: Cato-at-liberty - August 9, 2019 Category: American Health Authors: Corey A. DeAngelis Source Type: blogs
A Strong Currency Is No Good Reason to Keep Tariffs High
An interestingdebate has arisen in Ecuador during recent weeks over the following proposition advanced by authors at a Quito think tank: a dollarized country shouldn ’t reduce its tariffs when the dollar is overvalued relative to the currencies of its regional trading partners (according to purchasing-power-parity measures) because that would undermine its “competitiveness” in export market. As several commentators have noticed, this is reminiscent of the Mercantilist view that a country will lose too much of its gold if it does not discourage imports with tariffs or promote exports with subsidies, a view that David ...
Source: Cato-at-liberty - July 5, 2019 Category: American Health Authors: Lawrence H. White Source Type: blogs
#ThrowbackThursday: Complexity, Uncertainty, and Ambiguity in Professional Practice: Re-Engineering the Notion of Expertise in High-Stakes Situations
Editor’s Note: In honor of #ThrowbackThursday, we are highlighting this 2014 blog post from our archives. For more on how to navigate ambiguity, check out “A Philosophical Approach to Addressing Uncertainty in Medical Education” in the April 2019 issue of Academic Medicine.
At 10 years old, I had the dream of becoming an astronaut. Not one who flies space shuttles…I wanted to be a flight surgeon. I dreamed of being in a situation where I had to take control of a health care emergency in space.
At the same time, my country, Colombia, was going through the worst violence and social crisis in its history. Comple...
Source: Academic Medicine Blog - April 25, 2019 Category: Universities & Medical Training Authors: Guest Author Tags: Featured Guest Perspective medical education medical students patient care quality improvement Source Type: blogs
Podcast: From Homeless to Prisoner to Olympian
In his teens, Tony Hoffman was a BMX Amateur being featured on magazine covers. But soon after, he was a drug addict living in the streets and ultimately ending in prison. After his parole, a now clean Tony returned to the BMX world in a big way: by taking the silver medal in the 2016 Olympics. Since then, Tony has dedicated his life to helping others with addiction issues with his motivational speaking and special projects.
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About Our Guest
After paroling prison on December 13, 2008, Tony Hoffman started living out his dream, with his addiction behind...
Source: World of Psychology - April 4, 2019 Category: Psychiatry & Psychology Authors: The Psych Central Show Tags: General Recovery Sports The Psych Central Show Addiction BMX Gabe Howard Olympics prison Tony Hoffman Vincent M. Wales Source Type: blogs
Podcast: From Homeless to Prisoner to Olympic Coach
In his teens, Tony Hoffman was a BMX Amateur being featured on magazine covers. But soon after, he was a drug addict living in the streets and ultimately ending in prison. After his parole, a now clean Tony returned to the BMX world in a big way: by taking the silver medal in the 2016 UCI BMX World Championships. Since then, Tony has dedicated his life to helping others with addiction issues with his motivational speaking and special projects.
Subscribe to Our Show!
And Remember to Review Us!
About Our Guest
After paroling prison on December 13, 2008, Tony Hoffman started living out his dream, with h...
Source: World of Psychology - April 4, 2019 Category: Psychiatry & Psychology Authors: The Psych Central Show Tags: General Recovery Sports The Psych Central Show Addiction BMX Gabe Howard Olympics prison Tony Hoffman Vincent M. Wales Source Type: blogs
Podcast: Dwelling on the Past Mistakes Caused by Mental Illness
Once we reach recovery from mental illness, we tend to dwell on the mistakes of our past. Thoughts of failures and people we’ve hurt ruminate inside our head and make it difficult to move forward.
Why do we think about these things? Does it protect us, make us feel better, or is it way to keep us from moving forward? In this episode, our hosts discuss their past failures in the hopes it allows our listeners to realize living in the past only really accomplishes one thing . . .
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“It just creeps into the deep dark depths of my head and it just goes around, and around, and around.”
R...
Source: World of Psychology - April 1, 2019 Category: Psychiatry & Psychology Authors: A Bipolar, a Schizophrenic, and a Podcast Tags: A Bipolar, A Schizophrenic, and a Podcast Anxiety and Panic Depression Schizophrenia Source Type: blogs
Five Misconceptions about the Crisis in Venezuela
Some media reports and analyses on the latest developments in Venezuela are repeating the following five misconceptions: 1. “Juan Guaidó proclaimed himself president of Venezuela” Juan Guaid ó is the president of the National Assembly, a body that is controlled by the opposition. On January 10 a new presidential term started and, as required by the Constitution, the president-elect had to be sworn-in in front of the National Assembly. However, Nicolás Maduro was “reelected” last M ay in a sham election that the leading opposition parties were prevented from contesting it. Thus, on January 10 most Wes...
Source: Cato-at-liberty - January 28, 2019 Category: American Health Authors: Juan Carlos Hidalgo Source Type: blogs
Venezuela ’s Opposition Crosses the Rubicon
Juan Guaid ó, the president of Venezuela’s National Assembly, was sworn in today as the country’s interim president. The controversial move was expected after the opposition-controlled legislature last week invoked articles 233, 333 and 350 of the Constitution declaring Nicolás Maduro an “usurper.” P resident Trump quickly announced that Washington recognizes Guaidó as the legitimate president of Venezuela. Similar announcements came from Argentina, Brazil, Canada, Colombia, and other Latin American countries, as well as Luis Almagro, secretary general of the Organization of American States. Th is could well be ...
Source: Cato-at-liberty - January 23, 2019 Category: American Health Authors: Juan Carlos Hidalgo Source Type: blogs
BMC ‘Research in progress’ photo competition 2018: winning images
The objective of this collage is therefore to recognize diversity, as an essential aspect of our existence.
“Look into my eyes”Lidianne Salvatierra, Federal University of Tocantins (UFT), Brazil
Frontal face of a jumping spider (Salticidae). Jumping spiders have well developed eyes and can actually form images.
The post BMC ‘Research in progress’ photo competition 2018: winning images appeared first on Research in progress blog. (Source: BioMed Central Blog)
Source: BioMed Central Blog - December 14, 2018 Category: General Medicine Authors: Davy Falkner Tags: Open Access Publishing Research in progress photo competition Source Type: blogs
