Fight Aging! Newsletter, January 11th 2021
This study demonstrates the potential of a natural (o-Vanillin) and a synthetic (RG-7112) senolytic compounds to remove senescent IVD cells, decrease SASP factors release, reduce the inflammatory environment and enhance the IVD matrix production. Removal of senescent cells, using senolytics drugs, could lead to improved therapeutic interventions and ultimately decrease pain and a provide a better quality of life of patients living with intervertebral disc degeneration and low back pain.
From Ying Ann Chiao of Oklahoma Medical Research Foundation: Mitochondrial dysfunction plays a central role in aging and cardiovasc...
Source: Fight Aging! - January 10, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Ageless: The New Science of Getting Older Without Getting Old
is a forthcoming book discussing the aging research community and its newfound interest in treating aging as a medical condition. Aging is the cause of age-related disease and mortality, and far longer, far healthier lives lie ahead in the era in which the mechanisms of aging are targeted, rather than only their consequences. In this popular press article, the author and the book are discussed. The views are sensible and forward-looking, suggesting that it may be worth picking up when it is published in a few months.
The author began professional life as a physicist. As a child, he was fascinated by space, the wa...
Source: Fight Aging! - January 7, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Mitochondrial DNA in Extracellular Vesicles Declines with Age
A sizable fraction of cell signaling is conveyed via extracellular vesicles, tiny membrane-wrapped packages of molecules. Here researchers note that mitochondrial DNA is found inside extracellular vesicles, and that the amount declines with age. Other researchers have determined that entire mitochondria are exported and taken up by cells, so one has to carefully read the methods used in papers like this to ensure that researchers are in fact looking at the smaller extracellular vesicles only. These vesicles are sorted into category by size, and selecting by size is an established capability.
It is speculated that tr...
Source: Fight Aging! - January 1, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Podcast: From Divorce to Besties
How did Gabe and Lisa go from being spouses to divorcees to best friends? Do they hold any residual anger toward each other? Hurt feelings? Secret attraction? How do their current spouses feel about their friendship?
If you’re curious to understand their unique journey, join us as they tell all on today’s podcast.
(Transcript Available Below)
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About The Not Crazy podcast Hosts
Gabe Howard is an award-winning writer and speaker who lives with bipolar disorder. He is the author of the popular book, Mental Illness is an Asshole and other Observations...
Source: World of Psychology - December 15, 2020 Category: Psychiatry & Psychology Authors: Not Crazy Podcast Tags: Friends General Marriage and Divorce Not Crazy Podcast Relationships Source Type: blogs
Shingles: What triggers this painful, burning rash?
If you’re like 95% of American adults, you had chickenpox as a kid. Before the United States started its widespread vaccination program in 1995, there were roughly four million cases of chickenpox every year. So, most people suffered through an infection with this highly contagious virus and its itchy, whole-body rash.
But unlike many childhood viruses, the varicella-zoster virus that causes chickenpox doesn’t clear from the body when the illness ends. Instead it hangs around, taking up residence and lying dormant in the nerves, sometimes for decades, with the immune system holding it in check. In some people, it lives...
Source: Harvard Health Blog - December 14, 2020 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Health Healthy Aging Skin and Hair Care Vaccines Source Type: blogs
Fight Aging! Newsletter, December 14th 2020
In conclusion, aging alters the cerebral vasculature to impair mitochondrial function and mitophagy and increase IL-6 levels. These alterations may impair BBB integrity and potentially reduce cerebrovascular health with aging.
Senescent Cells Fail to Maintain Proteostasis
https://www.fightaging.org/archives/2020/12/senescent-cells-fail-to-maintain-proteostasis/
Given the newfound consensus in the research community regarding the importance of senescent cells to degenerative aging, it isn't surprising to see a great deal more fundamental research into the biochemistry of cellular senescence now taking pl...
Source: Fight Aging! - December 13, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Thymic Involution and the Decline of the Immune System with Age
Thymocytes created in the bone marrow travel to the thymus, and there mature into T cells of the adaptive immune system. The thymus, unfortunately, atrophies with age, a process known as thymic involution. By age 50 it is largely fat tissue, and the supply of new T cells diminishes to a trickle. In old age, the total number of T cells remains much the same as in youth, but absent regular reinforcements, all too many of these vital cells are worn, damaged, exhausted, senescent, and often pathologically misconfigured. Too few competent T cells remain to carry out the vital tasks of killing pathogens and errant, potentially c...
Source: Fight Aging! - December 7, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 23rd 2020
In conclusion, the study indicates that HBOT may induce significant senolytic effects that include significantly increasing telomere length and clearance of senescent cells in the aging populations.
Data on the Prevalence of Liver Fibrosis in Middle Age
https://www.fightaging.org/archives/2020/11/data-on-the-prevalence-of-liver-fibrosis-in-middle-age/
Fibrosis is a consequence of age-related disarray in tissue maintenance processes, leading to the deposition of scar-like collagen that disrupts tissue structure and function. It is an ultimately fatal issue for which there are only poor treatment options ...
Source: Fight Aging! - November 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Podcast: Can Swearing Improve Mental Health?
Ouch! You stub your toe or burn your finger and a curse word comes flying out. It’s automatic — and it probably makes you feel a little better. But have you ever considered specifically using curse words as a way to improve your mental health? That’s the idea behind our guest’s new book “Move On MF’er.”
In today’s show, we welcome psychologist and author Jodie Eckleberry-Hunt who explains how swearing can help us relieve the pain that overrides logic.
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Guest information for ‘Jodie Eckleberry-Hunt- Can Swearing Improve Mental Health’ Podcast Episode
Jodie Eckleb...
Source: World of Psychology - November 12, 2020 Category: Psychiatry & Psychology Authors: The Psych Central Podcast Tags: Anger General Interview LifeHelper Mental Health and Wellness Podcast Self-Help The Psych Central Show Source Type: blogs
9 Technologies That Will Shape The Future Of Dentistry
One of the most common childhood fears is going to the dentist. Who would not relate? Sitting in a huge chair illuminated by blinding light; enduring lengthy seated sessions with someone looking and poking inside your mouth using edgy and frightening devices. And finally, when the torture is over, that same someone tells you not to eat your favourite sweets and instructs you to brush your teeth regularly.
We’ve all been through this as a kid and childhood memories stick with us; just recalling this might send a shiver down your spine. No one likes to go to the dentist in spite of the fact that everyone knows how crucia...
Source: The Medical Futurist - November 3, 2020 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Artificial Intelligence in Medicine Biotechnology E-Patients Future of Medicine Future of Pharma Genomics Health Sensors & Trackers Medical Education Telemedicine & Smartphones Virtual Reality AI augmented reality dig Source Type: blogs
Caregiving for Schizophrenia
A third of all people will be a caregiver at some point in their lives. Caregiving for people with schizophrenia presents challenges that many people are ill-prepared for.
Host Rachel Star breaks down the principles of caregiving and creative ways to navigate schizophrenia.
Dr. Sarah Kopelovich joins to share schizophrenia caregiver specific training.
About our Guest
Sarah Kopelovich, PhD is a forensically-trained licensed clinical psychologist in the Department of Psychiatry and Behavioral Sciences at the University of Washington School of Medicine. Dr. Kopelovich is an Assistant Professor in the department and holds the...
Source: World of Psychology - October 21, 2020 Category: Psychiatry & Psychology Authors: Rachel Star Withers Tags: Brain and Behavior Caregivers Family Inside Schizophrenia Mental Health and Wellness Psychology Adult Caregiver Caregiver stress Family Caregivers life with schizophrenia Living With Schizophrenia Mental Illness Psychotherapy Sel Source Type: blogs
Inside Schizophrenia: Caregiving for Schizophrenia
A third of all people will be a caregiver at some point in their lives. Caregiving for people with schizophrenia presents challenges that many people are ill-prepared for.
Host Rachel Star breaks down the principles of caregiving and creative ways to navigate schizophrenia.
Dr. Sarah Kopelovich joins to share schizophrenia caregiver specific training.
About our Guest
Sarah Kopelovich, PhD is a forensically-trained licensed clinical psychologist in the Department of Psychiatry and Behavioral Sciences at the University of Washington School of Medicine. Dr. Kopelovich is an Assistant Professor in the department and holds the...
Source: World of Psychology - October 21, 2020 Category: Psychiatry & Psychology Authors: Rachel Star Withers Tags: Brain and Behavior Caregivers Family Inside Schizophrenia Mental Health and Wellness Psychology Adult Caregiver Caregiver stress Family Caregivers life with schizophrenia Living With Schizophrenia Mental Illness Psychotherapy Sel Source Type: blogs
Fight Aging! Newsletter, October 19th 2020
In conclusion, we found that regardless of the presence of multimorbidity, engaging in a healthier lifestyle was associated with up to 6.3 years longer life for men and 7.6 years for women; however, not all lifestyle risk factors equally correlated with life expectancy, with smoking being significantly worse than others.
A Hydrogel Scaffold to Encourage Peripheral Nerve Regeneration
https://www.fightaging.org/archives/2020/10/a-hydrogel-scaffold-to-encourage-peripheral-nerve-regeneration/
The nervous system of mammals is poorly regenerative at best. The use of implantable scaffold materials is one of th...
Source: Fight Aging! - October 18, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Using CRISPR to Remove Mutated Sequences of Nuclear DNA Required by Cancerous Cells
Fusion genes feature in many cancers, a form of mutation in which two genes are joined together, such as through deletion of the DNA sequences that normally separate the two genes. The resulting mutant fusion gene sequence encodes a fusion protein that can have novel effects, or in which both portions remain functional, but are now produced in at inappropriate times and in inappropriate amounts. This change in cell biochemistry can be important in driving cancerous behavior, and this appears to be the case in a meaningful fraction of cancer types.
Today's research materials discuss a clever use of CRISPR DNA editing...
Source: Fight Aging! - October 16, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
America needs to invest in proactive patient outreach now
The COVID-19 pandemic has introduced multiple new threats for physical and mental health. The novel coronavirus itself continues to infect more than 30,000 Americans as we enter the influenza season. The pandemic, economic devastation, and racial reckoning have led to a tripling of emotional distress. Essential preventive services such as cancer screenings, childhood vaccination, maintenance visits for […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 3, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/jason-bae-and-alan-glaseroff" rel="tag" > Jason Bae, MD and Alan Glaseroff, MD < /a > < /span > Tags: Policy COVID-19 coronavirus Infectious Disease Public Health & Source Type: blogs
