The TIRS trial: protocol for a cluster randomized controlled trial assessing the efficacy of preventive targeted indoor residual spraying to reduce Aedes -borne viral illnesses in Merida, Mexico
DiscussionThe findings from this study will provide robust epidemiological evidence of the efficacy of TIRS in reducing ABV illness and infection. If efficacious, TIRS could drive a paradigm shift inAedes control by consideringAe. aegypti behavior to guide residual insecticide applications and changing deployment to preemptive control (rather than in response to symptomatic cases), two major enhancements to existing practice.Trial registrationClinicalTrials.govNCT04343521. Registered on 13 April 2020. The protocol also complies with the WHO International Clinical Trials Registry Platform (ICTRP) (Additional file 1).Primary...
Source: Trials - October 8, 2020 Category: Research Source Type: clinical trials
Seamless Controlled Trial To Evaluate Safety And Immunogenicity of Chikungunya Vaccine in LatinAmerica and Asia
Condition: Chikungunya Interventions: Drug: BBV87 Chikungunya vaccine; Drug: Normal Saline Sponsor: International Vaccine Institute Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 28, 2020 Category: Research Source Type: clinical trials
Pivotal Study to Evaluate Safety and Immunogenicity of a Live-Attenuated Chikungunya Virus Vaccine Candidate in Adults
Condition: Chikungunya Virus Infection Interventions: Biological: VLA1553; Biological: Placebo Sponsor: Valneva Austria GmbH Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 14, 2020 Category: Research Source Type: clinical trials
