Efficacy of Immunization With 4C-MenB in Preventing Experimental Urethral Infection With Neisseria Gonorrhoeae
Condition: Gonorrhea Male Interventions: Drug: Cefixime; Drug: Ceftriaxone; Drug: Ciprofloxacin; Biological: Neisseria gonorrhoeae strain FA1090; Biological: Meningococcal Group B Vaccine; Biological: Influenza Vaccine; Biological: Tetanus-diptheria Vaccine Sponsors: University of North Carolina, Chapel Hill; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 24, 2022 Category: Research Source Type: clinical trials
Ceftriaxone to PRevent pneumOnia and inflammaTion aftEr Cardiac arresT (PROTECT): study protocol for a randomized, placebo-controlled trial
DiscussionThe PROTECT trial is novel in its (1) inclusion of OHCA survivors regardless of initial heart rhythm, (2) use of a low-risk antibiotic available in the USA that has not previously been tested after OHCA, (3) inclusion of anti-inflammatory effects of ceftriaxone as a novel mechanism for improved clinical outcomes, and (4) complete metagenomic assessment of bacterial resistomes pre- and post-ceftriaxone prophylaxis. The long-term goal is to develop a definitive phase III trial powered for mortality or functional outcome.Trial registrationClinicalTrials.govNCT04999592. Registered on August 10, 2021. (Source: Trials)
Source: Trials - March 4, 2022 Category: Research Source Type: clinical trials
Early Oral Step-down Antibiotic Therapy for Uncomplicated Gram-negative Bacteraemia
Condition: Gram-negative Bacteraemia Interventions: Drug: Oral fluoroquinolones (most commonly, ciprofloxacin) or oral trimethoprim-sulfamethoxazole; Drug: Standard of care intravenous antibiotics (e.g. ceftriaxone, cefazolin) Sponsors: Tan Tock Seng Hospital; Singapore Clinical Research Institute; National University Hospital, Singapore; Singapore General Hospital; Changi General Hospital; Ng Teng Fong General Hospital; Sengkang General Hospital; Royal Brisbane and Women's Hospital; John Hunter Hospital; Melbourne Health; Imperial College Healthcare N...
Source: ClinicalTrials.gov - January 20, 2022 Category: Research Source Type: clinical trials
Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL)
Condition: Endocarditis Interventions: Drug: Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin; Drug: Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline Sponsor: Vinay Badhwar Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 14, 2021 Category: Research Source Type: clinical trials
