Population Pharmacokinetics of Commonly Used Antimicrobial Agents in Children of Bacterial Meningitis With Augmented Renal Clearance
Conditions: Bacterial Meningitis; Augmented Renal Clearance Intervention: Drug: meropenem vancomycin ceftazidime ceftriaxone ceftizoxime linezolid Sponsors: Shandong University; Children's Hospital of Chongqing Medical University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 25, 2021 Category: Research Source Type: clinical trials
Zilucoplan in patients with acute hypoxic respiratory failure due to COVID-19 (ZILU-COV): A structured summary of a study protocol for a randomised controlled trial
AbstractObjectivesZilucoplan (complement C5 inhibitor) has profound effects on inhibiting acute lung injury post COVID-19, and can promote lung repair mechanisms that lead to improvement in lung oxygenation parameters. The purpose of this study is to investigate the efficacy and safety of Zilucoplan in improving oxygenation and short- and long-term outcome of COVID-19 patients with acute hypoxic respiratory failure.Trial designThis is a phase 2 academic, prospective, 2:1 randomized, open-label, multi-center interventional study.ParticipantsAdult patients ( ≥18y old) will be recruited at specialized COVID-19 units and ICU...
Source: Trials - November 19, 2020 Category: Research Source Type: clinical trials
PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke —statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment
DiscussionThis statistical analysis plan provides a technical description of the statistical methodology and unpopulated tables and figures. The paper is written prior to data lock and unblinding of treatment allocation.Trial registrationISRCTN registryISRCTN82217627. Registered on 22 September 2015. The trial was prospectively registered. (Source: Trials)
Source: Trials - October 26, 2020 Category: Research Source Type: clinical trials
The value of post-operative antibiotic therapy after laparoscopic appendectomy for complicated acute appendicitis: a prospective, randomized, double-blinded, placebo-controlled phase III study (ABAP study)
This study is a prospective, multicenter, parallel-group, randomized (1:1), double-blinded, placebo-controlled, phase III non-inferiority study with blind evaluation of the primary efficacy criterion. The primary objective is to evaluate the impact of the absence of post-operative antibiotic therapy on the organ/space surgical site infection (SSI) rate in patients presenting with CAA (other than in cases of generalized peritonitis). Patients in the experimental group will receive at least one dose of preoperative and perioperative antibiotic therapy (2 g ceftriaxone by intravenous injection every 24 h up to the operat...
Source: Trials - May 31, 2020 Category: Research Source Type: clinical trials
Prophylactic Antibiotics in Admitted Cirrhotics
Condition: Cirrhosis, Liver Interventions: Drug: Ceftriaxone; Drug: Normal saline Sponsors: Beth Israel Deaconess Medical Center; American Association for the Study of Liver Diseases Foundation Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 6, 2020 Category: Research Source Type: clinical trials
