Suspected Reaction with Cephalosporin May Be a Predictive Factor for β-Lactam Allergy in Children
Conclusion: Our study indicates that most patients with a suspected β-lactam allergy tolerated this drug. An appropriate diagnostic allergy workup may prevent the use of less effective and more expensive alternatives.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 5, 2018 Category: Allergy & Immunology Source Type: research
Community-Acquired Pneumonia in Children.
CONCLUSION: In previously healthy children under the age of 5 years, high dose amoxicillin is the treatment of choice. For those with type 1 hypersensitivity to penicillin, clindamycin, azithromycin, clarithromycin, and levofloxacin are reasonable alternatives. For children with a non-type 1 hypersensitivity to penicillin, cephalosporins such as cefixime, cefprozil, cefdinir, cefpodoxime, and cefuroxime should be considered. In previously healthy children over the age of 5 years, macrolides such as azithromycin and clarithromycin are the drugs of choice.
PMID: 29932038 [PubMed - as supplied by publisher] (Source: R...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 24, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
Biosynthesis of Cefprozil in an Aqueous Two-Phase System Composed of pH-Responsive Copolymers and its Crystallization Analysis
Publication date: Available online 7 October 2017 Source:Process Biochemistry Author(s): Hongxia Pan, Ting Yang, Jialing Chen, Xuejun Cao Cefprozil, a semi-synthetic antibiotic, has been used in pediatric therapy. The purpose of this study was to improve the yield of cefprozil and obtain purer product in an aqueous two-phase system composed of PADB and PMDB. PADB and PMDB were synthesized using acrylic acid, methacrylic acid, 2-dimethylaminoethyl methacrylate, and butyl methacrylate. Cefprozil was synthesized with 7-amino-3-(1-propenyl)-4-cephalosporanic acid (7-APRA) as the main ring, (R)-amino-(4-hydroxyphenyl) ace...
Source: Process Biochemistry - October 7, 2017 Category: Biochemistry Source Type: research
Determination and Correlation of Solubility of Cephradine
and Cefprozil Monohydrate in Water As a Function of pH
Journal of Chemical& Engineering DataDOI: 10.1021/acs.jced.7b00446 (Source: Journal of Chemical and Engineering Data)
Source: Journal of Chemical and Engineering Data - August 9, 2017 Category: Chemistry Authors: Hua Sun, Cuiyuan Jiang, Baoshu Liu and Junli zhang Source Type: research
Effects of quercetin on pharmacokinetics of cefprozil in Chinese-Han male volunteers.
Abstract
1. The primary objective of this study was to evaluate the effects of quercetin on the pharmacokinetics of cefprozil. The secondary objective was to evaluate the safety of the combined use of cefprozil and quercetin. 2. An open-label, two-period, crossover phase I trial among 24 Han Chinese male subjects was conducted. Participants were given 500 mg of quercetin orally once daily for 15 d followed by single dose of cefprozil (500 mg) on day 15. Serum concentrations of cefprozil were then measured in all participants on day 15. A 15-d washout period was then assigned after which a 500 mg dose...
Source: Xenobiotica - February 29, 2016 Category: Research Authors: Jia FF, Tan ZR, McLeod HL, Chen Y, Ou-Yang DS, Zhou HH Tags: Xenobiotica Source Type: research
In Vitro Activity of Oral Cephalosporins (Cefprozil and Cefixime) Against Ciprofloxacin-Resistant Enterobacteriaceae from Community-Acquired Urinary-Tract Infections
Conclusion
Results suggest that cefprozil and cefixime remain a good therapeutic alternative against urine enterobacteria particularly in case of ciprofloxacin-resistant pathogens. Their activity against ESBL-producing pathogens is limited. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 21, 2015 Category: Infectious Diseases Source Type: research
