Pharmacokinetic and Bioequivalence Evaluation of Two Cefprozil Dispersible Tablets in Healthy Chinese Volunteers
This study aimed to assess the bioequivalence of 2 cefprozil dispersible tablet formulations (250 mg) in healthy Chinese volunteers under fasting and fed conditions and to determine the pharmacokinetics of cefprozil. A randomized, single-dose, open-label, 2-formulation, 2-period study was conducted. The elimination period for this study was 7 days. Forty-eight healthy volunteers received 250-m g cefprozil dispersible tablets in each study period under both test and reference conditions. The test and the reference cefprozil were bioequivalent in healthy Chinese volunteers, and there was no significant food effect in indiv...
Source: Clinical Pharmacology in Drug Development - July 22, 2023 Category: Drugs & Pharmacology Authors: Lang Xu,
Jianfen Su,
Halimulati Muhetaer,
Canhua Zhang,
Chen Huang,
Yukuan Tang,
Xihua Fu,
Zhimin Liang Tags: Original Article Source Type: research
Heterologous expression, purification, and characterization of thermo- and alkali-tolerant laccase-like multicopper oxidase from Bacillus mojavensis TH309 and determination of its antibiotic removal potential
Arch Microbiol. 2023 Jul 16;205(8):287. doi: 10.1007/s00203-023-03626-5.ABSTRACTLaccases or laccase-like multicopper oxidases have great potential in bioremediation to oxidase phenolic or non-phenolic substrates. However, their inability to maintain stability in harsh environmental conditions and against non-substrate compounds is one of the main reasons for their limited use. The gene (mco) encoding multicopper oxidase from Bacillus mojavensis TH309 were cloned into pET14b( +), expressed in Escherichia coli, and purified as histidine tagged enzyme (BmLMCO). The molecular weight of the enzyme was about 60 kDa. The enzyme e...
Source: Archives of Microbiology - July 16, 2023 Category: Microbiology Authors: Ali Osman Adig üzel Serpil K önen-Adigüzel S ümeyye Cilmeli Birg ül Mazmancı Erdal Yabalak Sevde Üstün-Odabaşı Nisa G ül Kaya Mehmet Ali Mazmanc ı Source Type: research
Heterologous expression, purification, and characterization of thermo- and alkali-tolerant laccase-like multicopper oxidase from Bacillus mojavensis TH309 and determination of its antibiotic removal potential
Arch Microbiol. 2023 Jul 16;205(8):287. doi: 10.1007/s00203-023-03626-5.ABSTRACTLaccases or laccase-like multicopper oxidases have great potential in bioremediation to oxidase phenolic or non-phenolic substrates. However, their inability to maintain stability in harsh environmental conditions and against non-substrate compounds is one of the main reasons for their limited use. The gene (mco) encoding multicopper oxidase from Bacillus mojavensis TH309 were cloned into pET14b( +), expressed in Escherichia coli, and purified as histidine tagged enzyme (BmLMCO). The molecular weight of the enzyme was about 60 kDa. The enzyme e...
Source: Archives of Microbiology - July 16, 2023 Category: Microbiology Authors: Ali Osman Adig üzel Serpil K önen-Adigüzel S ümeyye Cilmeli Birg ül Mazmancı Erdal Yabalak Sevde Üstün-Odabaşı Nisa G ül Kaya Mehmet Ali Mazmanc ı Source Type: research
Heterologous expression, purification, and characterization of thermo- and alkali-tolerant laccase-like multicopper oxidase from Bacillus mojavensis TH309 and determination of its antibiotic removal potential
Arch Microbiol. 2023 Jul 16;205(8):287. doi: 10.1007/s00203-023-03626-5.ABSTRACTLaccases or laccase-like multicopper oxidases have great potential in bioremediation to oxidase phenolic or non-phenolic substrates. However, their inability to maintain stability in harsh environmental conditions and against non-substrate compounds is one of the main reasons for their limited use. The gene (mco) encoding multicopper oxidase from Bacillus mojavensis TH309 were cloned into pET14b( +), expressed in Escherichia coli, and purified as histidine tagged enzyme (BmLMCO). The molecular weight of the enzyme was about 60 kDa. The enzyme e...
Source: Archives of Microbiology - July 16, 2023 Category: Microbiology Authors: Ali Osman Adig üzel Serpil K önen-Adigüzel S ümeyye Cilmeli Birg ül Mazmancı Erdal Yabalak Sevde Üstün-Odabaşı Nisa G ül Kaya Mehmet Ali Mazmanc ı Source Type: research
A 37-Year-Old Man With Right Lung Consolidation
Chest. 2023 Mar;163(3):e111-e114. doi: 10.1016/j.chest.2022.10.022.ABSTRACTA 37-year-old man attended a medical clinic at the confluence of the Appalachian and the St. Lawrence Valley after 2 weeks of coughing greenish sputum and progressive dyspnea on exertion. In addition, he reported fatigue, fevers, and chills. He had quit smoking a year earlier and was not a drug user. He recently had spent most of his free time outdoors, mountain biking, but had not travelled outside of Canada. Medical history was unremarkable. He did not take any medication. Upper airway samples taken for SARS-CoV-2 proved negative; he was prescribe...
Source: Chest - March 9, 2023 Category: Respiratory Medicine Authors: Nicholas Quigley Christian Couture Philippe Gervais Fran çois Maltais Source Type: research
A 37-Year-Old Man With Right Lung Consolidation
Chest. 2023 Mar;163(3):e111-e114. doi: 10.1016/j.chest.2022.10.022.ABSTRACTA 37-year-old man attended a medical clinic at the confluence of the Appalachian and the St. Lawrence Valley after 2 weeks of coughing greenish sputum and progressive dyspnea on exertion. In addition, he reported fatigue, fevers, and chills. He had quit smoking a year earlier and was not a drug user. He recently had spent most of his free time outdoors, mountain biking, but had not travelled outside of Canada. Medical history was unremarkable. He did not take any medication. Upper airway samples taken for SARS-CoV-2 proved negative; he was prescribe...
Source: Chest - March 9, 2023 Category: Respiratory Medicine Authors: Nicholas Quigley Christian Couture Philippe Gervais Fran çois Maltais Source Type: research
Tanshinone I and Tanshinone IIA/B attenuate LPS-induced mastitis via regulating the NF- κB.
CONCLUSION: Tanshinone I and Tanshinone IIA/B have potentials in treating mastitis. The beneficial effects might be through regulating NF-κB activation.
PMID: 33578236 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 9, 2021 Category: Drugs & Pharmacology Authors: Yang L, Zhou G, Liu J, Song J, Zhang Z, Huang Q, Wei F Tags: Biomed Pharmacother Source Type: research
Pharmacokinetics and Bioequivalence of Cefprozil for Suspension and Granule Formulation in Healthy Chinese Volunteers: Two Single-Dose Crossover Studies
ConclusionsAccording to the criteria for bioequivalence, the test granule formulations of cefprozil and"Cefprozil for Suspension®" were determined to be bioequivalent whether under fasted or fed conditions by measurement of cis-, trans- and total cefprozil.Trial registrationClinicalTrials.gov identifier, NCT04414254. (Source: Advances in Therapy)
Source: Advances in Therapy - December 19, 2020 Category: Drugs & Pharmacology Source Type: research
Pharmacokinetic comparison with different assays for simultaneous determination of cis-, trans-cefprozil diastereomers in human plasma
Publication date: Available online 5 July 2020Source: Journal of Pharmaceutical AnalysisAuthor(s): Seung-Hyun Jeong, Ji-Hun Jang, Hea-Young Cho, Yong-Bok Lee (Source: Journal of Pharmaceutical Analysis)
Source: Journal of Pharmaceutical Analysis - July 6, 2020 Category: Drugs & Pharmacology Source Type: research
A child with Kawasaki disease successfully treated with Chinese herbal medicine: a case report with 12-month follow up
ConclusionsIn this case, CHM may be an effective alternative therapy for the treatment of KD, and furthermore, may also be applied as an option to salvage failed intravenous immunoglobulin procedures. Further controlled trials are warranted to determine whether this is an effective treatment option for other cases of KD. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - April 23, 2019 Category: Complementary Medicine Source Type: research
Clinical Outcomes of Failing to Dose-Reduce Cephalosporin Antibiotics in Older Adults with CKD.
CONCLUSIONS: In this study we failed to demonstrate any association between the dose of cephalosporin antibiotic administered to elderly patients with CKD and the risk of side-effects leading to hospitalization, treatment failure, or mortality.
PMID: 30630861 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 10, 2019 Category: Urology & Nephrology Authors: Bathini L, Jandoc R, Kuwornu P, McArthur E, Weir MA, Sood MM, Battistella M, Muanda FT, Liu A, Jain AK, Garg AX Tags: Clin J Am Soc Nephrol Source Type: research
Suspected Reaction with Cephalosporin May Be a Predictive Factor for β-Lactam Allergy in Children
Conclusion: Our study indicates that most patients with a suspected β-lactam allergy tolerated this drug. An appropriate diagnostic allergy workup may prevent the use of less effective and more expensive alternatives.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - December 5, 2018 Category: Allergy & Immunology Source Type: research
Community-Acquired Pneumonia in Children.
CONCLUSION: In previously healthy children under the age of 5 years, high dose amoxicillin is the treatment of choice. For those with type 1 hypersensitivity to penicillin, clindamycin, azithromycin, clarithromycin, and levofloxacin are reasonable alternatives. For children with a non-type 1 hypersensitivity to penicillin, cephalosporins such as cefixime, cefprozil, cefdinir, cefpodoxime, and cefuroxime should be considered. In previously healthy children over the age of 5 years, macrolides such as azithromycin and clarithromycin are the drugs of choice.
PMID: 29932038 [PubMed - as supplied by publisher] (Source: R...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 24, 2018 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research
Biosynthesis of Cefprozil in an Aqueous Two-Phase System Composed of pH-Responsive Copolymers and its Crystallization Analysis
Publication date: Available online 7 October 2017 Source:Process Biochemistry Author(s): Hongxia Pan, Ting Yang, Jialing Chen, Xuejun Cao Cefprozil, a semi-synthetic antibiotic, has been used in pediatric therapy. The purpose of this study was to improve the yield of cefprozil and obtain purer product in an aqueous two-phase system composed of PADB and PMDB. PADB and PMDB were synthesized using acrylic acid, methacrylic acid, 2-dimethylaminoethyl methacrylate, and butyl methacrylate. Cefprozil was synthesized with 7-amino-3-(1-propenyl)-4-cephalosporanic acid (7-APRA) as the main ring, (R)-amino-(4-hydroxyphenyl) ace...
Source: Process Biochemistry - October 7, 2017 Category: Biochemistry Source Type: research
Determination and Correlation of Solubility of Cephradine
and Cefprozil Monohydrate in Water As a Function of pH
Journal of Chemical& Engineering DataDOI: 10.1021/acs.jced.7b00446 (Source: Journal of Chemical and Engineering Data)
Source: Journal of Chemical and Engineering Data - August 9, 2017 Category: Chemistry Authors: Hua Sun, Cuiyuan Jiang, Baoshu Liu and Junli zhang Source Type: research
