Iron-catalyzed carbonylative Suzuki reactions under atmospheric pressure of carbon monoxide
ChemCommIron-catalyzed carbonylative Suzuki reactions under atmospheric pressure of carbon monoxide Yanzhen Zhong and Wei Han (Source: Organometallic Current)
Source: Organometallic Current - March 6, 2014 Category: Chemists Tags: Carbonylation Fe catalyzed Suzuki coupling Source Type: blogs
Head Versus Heart: Do Passions Fuel Good MS Science or Drive Unrealistic Hopes?
This study will add steroid therapy to the use of high-pressure oxygen to examine its result on recovery from MS attacks.
The current science on HBOT and multiple sclerosis stands as below:
“HBOT is not a cure, but there is evidence to suggest some symptomatic benefit in a majority of patients and apparent stabilization or slowing of progression in a significant fraction (17 to 33%) of those who receive continuing therapy over a period of 10 years or longer. HBOT in MS has few side effects, mostly minor.” -Richard A. Neubauer, M.D., Virginia Neubauer, and Sheldon F. Gottlieb, Ph.D. (Journal of American Physicians...
Source: Life with MS - February 10, 2014 Category: Other Conditions Authors: Trevis Gleason Tags: MS multiple sclerosis MS treatment multiple sclerosis clinical trials research Source Type: blogs
New Study Finds that Vaping Does Not Expose Bystanders to Carbon Monoxide or Volatile Organic Compounds
A new study published online ahead of print in the journal Nicotine and Tobacco Research reports the results of an experiment in which vapor from electronic cigarettes was generated in an experimental chamber, either by a machine or by human users. The investigators measured the levels of nicotine, carbon monoxide, and 11 volatile organic compounds. There were two major study findings:1. The electronic cigarettes did not produce detectable levels of carbon monoxide or any of the 11 volatile organic compounds, which included benzene, toluene, chlorobenzene, ethylbenzene, xylene, styrene, naphthalene, 1,2-dichlorobenzene, 1,...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - December 17, 2013 Category: Health Medicine and Bioethics Commentators Source Type: blogs
First Study to Examine Passive Vaping Under Real-Life Conditions Finds No Chemicals of Concern in Room Air
In the first study of human exposure produced by passive vaping under real-life conditions, researchers from Italy and Greece found no chemicals of concern in room air while five electronic cigarette users vaped for a five-hour session in a 60 cubic meter closed room.The researchers compared the constituents of room air during passive vaping to those present during passive smoking. During passive smoking, levels of chemicals were as follows (all in micrograms per cubic meter):Nicotine: 34Acrolein: 20Polycyclic aromatic hydrocarbons: 9.4Carbon monoxide: 11Xylene: 0.2Toluene: 1.7The detected levels of these same chemicals du...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - December 11, 2013 Category: Health Medicine and Bioethics Commentators Source Type: blogs
Winter is Coming: Be Prepared and Stay Safe
From the Centers for Disease Control and Prevention:
Although winter comes as no surprise, many of us are not ready for its arrival. If you are prepared for the hazards of winter, you will be more likely to stay safe and healthy when temperatures start to fall.
Many people prefer to remain indoors in the winter, but staying inside is no guarantee of safety. Take these steps to keep your home safe and warm during the winter months.
Winterize your home.
Install weather stripping, insulation, and storm windows.
Insulate water lines that run along exterior walls.
Clean out gutters and repair roof leaks.
Check your heating ...
Source: BHIC - November 8, 2013 Category: Databases & Libraries Authors: Naomi Gonzales Tags: Emergency Preparedness Public Health Source Type: blogs
E-Cig Popularity on the Rise
Cigarette smoking among American teenagers dropped to a record low in 2012. But are teens turning to a new alternative known as “e-cigarettes”?
According to the Food and Drug Administration (FDA), electronic cigarettes (e-cigs) are battery-operated products designed to deliver nicotine, flavor, and other chemicals as vapor that a user inhales, without producing actual tobacco smoke. Some people assume e-cigs are healthier than traditional cigarettes.
A survey conducted by the Centers for Disease Control and Prevention found that the use of e-cigs has doubled since 2011, raising the percentage of high school students wh...
Source: NIDA Drugs and Health Blog - November 7, 2013 Category: Addiction Authors: Sara Bellum Source Type: blogs
On the Same Day, Two More Tobacco Control Practitioners Tell the Public that Smoking May Be as Safe as Using Electronic Cigarettes
If a tobacco company were to publicly state that we don't know if smoking is any more hazardous than using non-tobacco, non-combusted electronic cigarettes, we would instantly attack those companies and perhaps initiate a lawsuit, claiming public fraud. We would cite the damages caused to the public by undermining their appreciation of the serious hazards of cigarette smoking by even suggesting that these products, which kill more than 400,000 Americans each year, may be no more hazardous than inhaling aerosol from a mixture of propylene glycol and nicotine (that contains no tobacco and involves no combustion).But what hap...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - October 31, 2013 Category: Health Medicine and Bioethics Commentators Source Type: blogs
A Carbon Monoxide Detector May Be Your Most Important Piece of Cold Weather Camping Equipment
An inexpensive carbon monoxide detector may prevent your next overnight cold weather adventure from becoming your last. Outdoor enthusiasts are sicken or killed every year by this odorless, colorless gas.Contributor: S. T. MartinPublished: Oct 20, 2013 (Source: Most Recent Health Wellness - Associated Content)
Source: Most Recent Health Wellness - Associated Content - October 20, 2013 Category: Other Conditions Source Type: blogs
Medical Mispronunciations and Misspelled Words: The Definitive List.
Hearing medical mispronunciations and seeing misspelled words are an under appreciated joy of working in healthcare. Physicians often forget just how alien the language of medicine is to people who don't live it everyday. The best part about being a physician is not helping people recover from critical illness. The best part is not about listening and understanding with compassion and empathy. Nope, the best part about being a physician is hearing patients and other healthcare providers butcher the language of medicine and experiencing great entertainment in the process. Doctors c...
Source: The Happy Hospitalist - October 2, 2013 Category: Internists and Doctors of Medicine Authors: Tamer Mahrous Source Type: blogs
Current Wisdom: We Calculate, You Decide: A Handy-Dandy Carbon Tax Temperature-Savings Calculator
Patrick J. Michaels and Paul C. "Chip" Knappenberger
The Current Wisdom is a series of monthly articles in which Patrick J. Michaels, director of the Center for the Study of Science, reviews interesting items on global warming in the scientific literature that may not have received the media attention that they deserved, or have been misinterpreted in the popular press. In this special issue, we focus on the climate implications of a carbon tax.
A year ago, July 23, 2012 to be precise, former Republican congressman Bob Inglis famously predicted the facts on global warming will “overwhelm” GOP resistance t...
Source: Cato-at-liberty - July 23, 2013 Category: Health Medicine and Bioethics Commentators Authors: Patrick J. Michaels, Paul C. "Chip" Knappenberger Source Type: blogs
New paper from the Eisen lab: Sporulation phylogenetic profiling
Quick post here. This paper came out a few months ago but it was not freely available so I did not write about it until now as it just showed up in Pubmed Central. It was published in the Journal of Bacteriology but they do not release material for free onto their website or Pubmed Central for a few months. Alas, as I was kind of a peripheral player in the main work in the paper (I helped them with the phylogenetic profiling part) I did not end up pushing as hard as I should have for paying the open access fee to make it available earlier / openly.
Here is a link to the paper: Gene Conservation among Endospore-Forming ...
Source: The Tree of Life - July 18, 2013 Category: Medical Scientists Authors: Jonathan Eisen Source Type: blogs
First-Ever Clinical Trial of Electronic Cigarettes Finds 13% One-Year Quit Rate Among Smokers with No Interest in Quitting
In this study, a group of 300 smokers with no interest in quitting were randomized to one of three groups:A: Electronic cigarettes with 7.2 mg nicotine cartridges for 12 weeksB: Electronic cigarettes with 7.2 mg nicotine cartridges for 6 weeks, then 5.4 mg nicotine cartridges for 6 weeksC: Electronic cigarettes with 0 mg nicotine cartridgesThe subjects were followed for one year. Smoking cessation was verified with exhaled carbon monoxide measurements.The follow-up rate ranged from 55% to 65%. Because of the loss to follow-up, an intent-to-treat analysis was used.The major result was that the 12-month smoking cessation rat...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - June 26, 2013 Category: Health Medicine and Bioethics Commentators Source Type: blogs
Smoking and Surgery Don’t Mix
Even routine operations are riskier for smokers.
Smokers who are scheduling a medical operation might want to think seriously about quitting, once they hear the results of a new review of the impact of smoking on surgical outcomes.
A scheduled operation is the perfect incentive for smokers to quit smoking. The fact that smokers have poorer post-surgical outcomes, with longer healing times and more complications, is not a new finding. But the study by researchers from the University of California in San Francisco, and Yale University School of Medicine, published in the Journal of Neurosurgery, spells out the surgicial r...
Source: Addiction Inbox - June 22, 2013 Category: Addiction Authors: Dirk Hanson Source Type: blogs
Check Out These Molecules
It's molecular imaging week! See Arr Oh and others have sent along this paper from Science, a really wonderful example of atomic-level work. (For those without journal access, Wired and PhysOrg have good summaries).
As that image shows, what this team has done is take a starting (poly) phenylacetylene compound and let it cyclize to a variety of products. And they can distinguish the resulting frameworks by direct imaging with an atomic force microscope (using a carbon monoxide molecule as the tip, as in this work), in what is surely the most dramatic example yet of this technique's application to small-molecule structure...
Source: In the Pipeline - May 31, 2013 Category: Chemists Tags: Chemical News Source Type: blogs
Your Brain Shifts Gears
Want to be weirded out? Study the central nervous system. I started off my med-chem career in CNS drug discovery, and it's still my standard for impenetrability. There's a new paper in Science, though, that just makes you roll your eyes and look up at the ceiling.
The variety of neurotransmitters is well appreciated - you have all these different and overlapping signaling systems using acetylcholine, dopamine, serotonin, and a host of lesser-known molecules, including such oddities as hydrogen sulfide and even carbon monoxide. And on the receiving end, the various subtypes of receptors are well studied, and those give a t...
Source: In the Pipeline - May 9, 2013 Category: Chemists Tags: The Central Nervous System Source Type: blogs
