A general catalytic β-C–H carbonylation of aliphatic amines to β-lactams
ByDarren Willcox,Ben G. N. Chappell,Kirsten F. Hogg,Jonas Calleja,Adam P. Smalley,Matthew J. GauntScience18 Nov 2016 : 851-857A bulky carboxylate ligand steers palladium to couple carbon monoxide and secondary amines into a versatile motif for drug research. (Source: Organometallic Current)
Source: Organometallic Current - November 18, 2016 Category: Chemistry Tags: C-H Functionalization Carbonylation Lactams Pd Catalyzed Source Type: blogs
Healthcare Is Coming Home With Sensors And Algorithms
Instead of futuristic hospital buildings and huge devices, disruptive technologies injected into small, almost invisible objects will set the trends in medicine. Such devices will create smart households bringing healthcare home.
Anna could not figure out what is wrong with her: in spite of being generally healthy, she has been sweating during sleep for days, she had lost some weight although she gave up her diet a while ago and she has been feeling mortifyingly tired for a while. It was not only her who noticed these symptoms but also her smart home: the sleep tracker mattress, the microchip in the toilet which detected...
Source: The Medical Futurist - August 30, 2016 Category: Information Technology Authors: nora Tags: Health Sensors & Trackers Healthcare Design future of hospital gc4 ibm watson Personalized medicine smart home technology Source Type: blogs
New Study Shows Dramatic Reduction in Toxicant and Carcinogen Levels in Smokers Who Switch to E-Cigarettes
This study suggests that smokers who completely switch to e-cigarettes and stop smoking tobacco cigarettes may significantly reduce their exposure to many cancer-causing chemicals. "Most importantly:" The decline in toxicant levels was similar to the decline seen among tobacco users who quit smoking. "The paper explains that:" the observed decline in various urine toxicant biomarker levels in our study was similar to decline among smokers who have quit smoking completely and did not substitute with any other product. This observation suggests that e-cigarettes are not a significant source of exposure to those toxicants. "T...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - August 25, 2016 Category: Addiction Source Type: blogs
Research and Reviews in the Fastlane 147
In this report two cases where a new method for removing encircling objects from the penis using a ordinary condom was applied. The article in danish with a short abstract, but sufficient self explanatory images are provided.
Recommended by Soren Rudolph
Resuscitation
Laina A et al. Amiodarone and cardiac arrest: Systematic review and meta-analysis. Internat J Cardiol 2016; 221: 780-8. PMID: 27434349
Amiodarone is dead in the dead! The recent ALPs trial in the NEJM grabbed headlines showing that there was no difference in survival to discharge in OHCA patients who got amiodarone versus lidocaine versus placebo. This s...
Source: Life in the Fast Lane - August 17, 2016 Category: Emergency Medicine Authors: Justin Morgenstern Tags: Education Emergency Medicine R&R in the FASTLANE Resuscitation Toxicology and Toxinology Trauma EBM literature recommendations research and reviews Source Type: blogs
Study Demonstrates Low Health Risks Associated with " Secondhand Vapor " from E-Cigarettes
A < a href= " http://www.ncbi.nlm.nih.gov/pubmed/24336346 " > study < /a > published in the journal < i > Nicotine & amp; Tobacco Research < /i > demonstrates that " secondhand vapor " from e-cigarettes poses very little risk to bystanders. < br / > < br / > (See: Czogala J, et al. Secondhand exposure to vapors from electronic cigarettes. Nicotine & amp; Tobacco Research 2014; 16(6):655-662.) < br / > < br / > The study methods were as follows: < i > " We measured selected airborne markers of secondhand exposure: nicotine, aerosol particles (PM(2.5)), carbon monoxide, and volatile organic compounds (VOCs) in an expos...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - July 27, 2016 Category: Addiction Source Type: blogs
Prevent Carbon Monoxide Poisoning
According to the Centers for Disease Control, 50,000 people a year visit the emergency department because of carbon monoxide poisoning. Carbon monoxide is odorless and colorless, but poisoning can be prevented.
Resources to learn more include:
Carbon Monoxide (CO) Poisoning Prevention (CDC): http://bit.ly/2ab3kql
Carbon Monoxide Poisoning (MedlinePlus): http://bit.ly/29QhRWa (Source: BHIC)
Source: BHIC - July 18, 2016 Category: Databases & Libraries Authors: Kate Flewelling Tags: Emergency Preparedness Environmental Health Source Type: blogs
Case Study: Sensor Selection for Remote Monitoring
In a previous blog post, I highlighted general principles for implementing and scaling systems to support remote monitoring of chronic conditions, namely congestive heart failure (CHF), Diabetes Mellitus (Type II Diabetes) and chronic obstructive pulmonary disease (COPD). In this blog post I will focus on COPD as a case study for the development, implementation and scaling of a remote monitoring system.
Definition of COPD
The World Health Organization (WHO) defines COPD as a “…lung disease characterized by chronic obstruction of lung airflow that interferes with normal breathing and is not fully reversible [̷...
Source: Medical Connectivity Consulting - May 10, 2016 Category: Information Technology Authors: Bridget Moorman Tags: Mobile Health Source Type: blogs
LITFL Review 229
Welcome to the 229th LITFL Review! Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chuck of FOAM.
The Most Fair Dinkum Ripper Beauts of the Week
Simon Carley and Robert Lloyd have an amazing podcast discussing resilience, mindfulness, stress innoculation, procedural expertise, and more as Robert shares his story of being an Englishman in South Africa. [SO]
The ESICM-led Trauma 2016 confere...
Source: Life in the Fast Lane - May 1, 2016 Category: Emergency Medicine Authors: Marjorie Lazoff, MD Tags: Education LITFL review Source Type: blogs
Are essential oils safe for children?
On January 5, 2016, emergency crews were called to Our Kids Daycare and Learning Center in Middleton, Idaho. The reason: concern for carbon monoxide poisoning. The daycare center’s director Robin Hagaman noted that some of the 12 toddlers in the classroom were acting strangely when they awakened from their naps and were also noted to have dilated pupils. In addition, two of the teachers were simultaneously experiencing headaches and nausea. The kids were moved out of that room toward another end of the facility, but carbon monoxide was not found to be the cause for the symptoms. Instead, blame was shifted to the essentia...
Source: Kevin, M.D. - Medical Weblog - March 13, 2016 Category: Journals (General) Authors: Justin Morgan, MD Tags: Meds Pediatrics Source Type: blogs
LITFL Review 212
Welcome to the 212th LITFL Review! Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chuck of FOAM.
The Most Fair Dinkum Ripper Beauts of the Week
Incredible talk from SMACC Chicago on Performance Psychology for Resuscitationists from Jason Brooks. [AS]
The Best of #FOAMed Emergency Medicine
Peripheral vertigo and no meclizine? Ryan Radecki tells us not to worry because promethazin...
Source: Life in the Fast Lane - December 27, 2015 Category: Emergency Medicine Authors: Marjorie Lazoff, MD Tags: Education LITFL review Source Type: blogs
What is the treatment for this subendocardial ischemia?
This elderly patient had an accidental carbon monoxide poisoning. The patient did not have ischemic symptoms, but we do an ECG routinely to look for ischemia. Here it is:There is ischemic ST depression, typical of diffuse subendocardial ischemia.The CO level returned at 28%.We consider cardiac ischemia (on the ECG, or by elevated troponin), by itself, to be an indication for emergent hyperbaric oxygen (HBO) even if there are no other indications such as neurologic disability, loss of consciousness, level greater than 40%, pregnancy, or other indications. We happen to have one of the world's finest hyperbaric ox...
Source: Dr. Smith's ECG Blog - November 17, 2015 Category: Cardiology Authors: Steve Smith Source Type: blogs
Heat Shock Proteins and Hormesis as a Basis for Therapy
As this open access paper demonstrates, researchers continue to discuss manipulation of heat shock proteins and the hormetic response to mild levels of cell damage or stress as a basis for possible therapies to slow some of the consequences of aging. These proteins are a crucial part of cellular housekeeping mechanisms, and increasing their activity has been fairly conclusively demonstrated to be beneficial in a variety of species. Despite more than a decade of intent to do something along these lines, and some recent signs of progress, there has been little to no concrete movement beyond the laboratory, however.
Modulati...
Source: Fight Aging! - November 16, 2015 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Contrary to the Way Results Were Reported, New Study Did Not Find a Reduction in Cigarettes Smoked with Low-Nicotine Cigarettes
New research published in the New England Journal of Medicine is widely being reported by anti-smoking groups and advocates as having found that subjects who received low-nicotine cigarettes significantly decreased their cigarette consumption. For example, the Campaign for Tobacco-Free Kids claimed that: "After six weeks, smokers given cigarettes with 2.4 mg of nicotine or less smoked significantly fewer cigarettes per day... ." Dr. Stan Glantz claimed that "smokers smoke less" after big cuts in nicotine in cigarettes. And the study itself concluded that "these data suggest that if nicotine content is adequately reduced, s...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - October 1, 2015 Category: Addiction Source Type: blogs
Study on Potential Toxicity of E-Cigarette Flavorings Produces Unwarranted Scare
A study published in the journal Tobacco Control this past April has produced an unwarranted scare about the potential toxicity of the flavorings in electronic cigarettes.(See: Tierney PA, et al. Flavour chemicals in electronic cigarette fluids. Tobacco Control. Published online ahead of print on April 15, 2015. DOI: 0.1136/tobaccocontrol-2014-052175.)The study used gas chromatography/mass spectrometry to analyze the chemical constituents in e-liquids of various flavors. It appears that 30 different e-liquid flavors were tested. Multiple flavors of two brands of disposable e-cigarettes (Blu and NJOY) were tested along with...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - July 16, 2015 Category: Addiction Source Type: blogs
LITFL Review 182
Welcome to the 182nd LITFL Review. Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chuck of FOAM.The Most Fair Dinkum Ripper Beauts of the Week Essentials of Emergency Medicine is offering a US resident scholarship in partnership with ALiEM and EMCrit for the October Essentials course in Las Vegas. Check it out and apply now! [AS] The Best of #FOAMed Emergency MedicineGreat pearl from ...
Source: Life in the Fast Lane - May 17, 2015 Category: Emergency Medicine Authors: Marjorie Lazoff, MD Tags: Education LITFL review Source Type: blogs
