Fight Aging! Newsletter, December 21st 2020
In this study, we have found that administration of a specific Sgk1 inhibitor significantly reduces the dysregulated form of tau protein that is a pathological hallmark of AD, restores prefrontal cortical synaptic function, and mitigates memory deficits in an AD model. These results have identified Sgk1 as a potential key target for therapeutic intervention of AD, which may have specific and precise effects."
Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease
Epigenetic aberration is implicated in aging and neurodegeneration. Using p...
Source: Fight Aging! - December 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Radiotherapy to Prevent Recurrence Post Brain Tumor Excision: Interview with Matthew Likens, President and CEO of GT Medical
GT Medical Technologies, a company based in Arizona, has developed the FDA-approved GammaTile system, which can provide localized radiation therapy for brain tumor excision sites. Its goal is to reduce tumor recurrence and enhance patient survival. The treatment consists of radiation seeds encased in a collagen substrate. These are easy to place at the excision site with a minimum of effort at the end of a surgical procedure.
Unfortunately, brain tumor recurrence is relatively common, and so treatments that can help to reduce this phenomenon, while sparing healthy tissues and reducing side effects, are very welcome. The...
Source: Medgadget - December 15, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Materials Medicine Neurosurgery Oncology Radiation Oncology Radiology Source Type: blogs
Greater Senescent Cell Burden Correlates with a Worse Cervical Cancer Survival Rate
It is thought that the burden of senescent cells is likely correlated with survival in many cancers. Senescent cells cease to replicate and begin to secrete pro-growth, pro-inflammation signals. Most senescent cells are rapidly destroyed by the immune system, but this process slows with age and thus senescent cells accumulate. Cellular senescence does act to suppress cancer in its earliest stages, by removing those cells most likely to become cancerous. Once a significant number of senescent cells are present, however, their signaling begins to aid cancer growth. Thus we might expect to see that the application of senolyti...
Source: Fight Aging! - December 14, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
New study compares long-term side effects from different prostate cancer treatments
Prostate cancer therapies are improving over time. But how do the long-term side effects from the various options available today compare? Results from a newly published study are providing some valuable insights.
Investigators at Vanderbilt University and the University of Texas MD Anderson Cancer Center spent five years tracking the sexual, bowel, urinary, and hormonal status of nearly 2,000 men after they had been treated for prostate cancer, or monitored with active surveillance (which entails checking the tumor periodically and treating it only if it begins to grow). Cancers in all the men were still confined to the p...
Source: Harvard Health Blog - February 27, 2020 Category: Consumer Health News Authors: Charlie Schmidt Tags: Health Prostate Knowledge Treatments HPK Source Type: blogs
3D Ultrasound Developed to Guide Treatment of Gynecological Cancers
Researchers at Western University, London Health Sciences Centre, and Lawson Health Research Institute, all in Canada, have developed and tested a new 3D ultrasound system. Designed to improve the accuracy of interstitial brachytherapy, a technique in which tiny sources of radiation are placed inside tumors, the new ultrasound may help physicians to significantly improve their targeting accuracy.
The technology is particularly useful in transvaginal procedures, such as those initiated to attack vaginal, cervical, and uterine cancers, since physicians typically don’t have a clear view of the anatomical features they&#...
Source: Medgadget - May 30, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Ob/Gyn Oncology Source Type: blogs
Self Forming Injectable Gel for Cervical Brachytherapy Procedures
A Virginia Tech polymer chemist and a University of Virginia clinical oncologist, have teamed up to create a special gel to reduce the pain associated with cervical cancer brachytherapy. This kind of therapy involves placing radioactive sources near the location of tumors, which essentially kill the cancer cells. Gauze is placed within the vagina to help with bleeding and other side effects, and it along with the cells dying from the therapy generates pain.
The new gel is made to replace the gauze with something more pleasant, and biocompatible gels can be very smooth, soft, and conforming. The new gel from he researchers...
Source: Medgadget - November 27, 2018 Category: Medical Devices Authors: Editors Tags: Ob/Gyn Oncology Radiation Oncology Source Type: blogs
A mix of treatments may extend life for men with aggressive prostate cancer
For men diagnosed with aggressive cancer that’s confined to the prostate and nearby tissues, the overarching goal of treatment is to keep the disease from spreading (or metastasizing) in the body. Doctors can treat these men with localized therapies, such as surgery and different types of radiation that target the prostate directly. And they can also give systemic treatments that kill off rogue cancer cells in the bloodstream. Hormonal therapy, for instance, is a systemic treatment that kills prostate cancer cells by depriving them of testosterone, which fuels their growth.
Now a new study shows that a mix of different t...
Source: Harvard Health Blog - March 31, 2018 Category: Consumer Health News Authors: Charlie Schmidt Tags: Cancer Men's Health Prostate Health Source Type: blogs
Brachytherapy for Breast Cancer Follow Up
Back in 2007, when I was diagnosed and treated for my breast cancer, I heard about this new technique for the radiation portion of treatment,brachytherapy. I was jealous. It was not offered at my hospital. The big thing I liked was that it took so much less time for treatment.Breast cancer treatment takes a LONG time. I was diagnosed at the end of May, after two surgeries that went into July, I finished chemo in December, and needed one more surgery (don ' t ask). I was then facing 7 weeks of radiation. I just wanted to be done. Since brachytherapy wasn ' t available I had the standard radiation treatment. I couldn ' t eve...
Source: Caroline's Breast Cancer Blog - February 11, 2018 Category: Cancer & Oncology Tags: breast cancer treatment cancer research radiation Source Type: blogs
Uveal Melanoma: The Basics
The uvea of the eye is a vascular tunic comprised of the iris, ciliary body, and choroid. Located between the sclera and the retina, the uvea contains dendritic pigmented melanocytes which have the potential to give rise to malignant melanoma. Patients with choroidal melanoma typically present as adults with painless monocular vision loss, while a cataract or glaucoma may be the presenting feature of an anterior segment melanoma.Approximately half of patients with choroidal and ciliochoroidal melanomas eventually die from their tumors. Prognosis is better in cases localized to the iris, presumably because they are recogniz...
Source: neuropathology blog - February 1, 2018 Category: Radiology Tags: eye Source Type: blogs
Sensus Healthcare ’s Technology Uses Low-Energy X-rays Directly on Cancer Cells: Interview with CEO Joe Sardano
Sensus Healthcare is a medical device company that focuses on providing non-invasive and cost-effective treatment of non-melanoma skin cancers and keloids utilizing superficial radiation technology (SRT). Their proprietary, FDA-cleared SRT technology is used to effectively and safely treat oncological and non-oncological skin conditions. The radiation is focused onto cancer cells almost exclusively, and it penetrates no more than 5mm under the surface of the skin, sparing nearby tissues.
In 2013, Sensus Healthcare received FDA clearance in the United States to treat keloids with the SRT-100 device. Earlier this summer, Chi...
Source: Medgadget - November 20, 2017 Category: Medical Devices Authors: Alice Ferng Tags: Dermatology Exclusive Oncology Source Type: blogs
Don ’t Underestimate Patients
By GEORGE BERGER, PHD
I was diagnosed with aggressive but localized prostate cancer at a major Dutch academic hospital. My parameters were PSA 29 or 31, Gleason sum 4 + 4, and stage T2c. Fortunately, there were no detectable distant metastases. The specialist drew a simple image of my urinary tract and told me I was excluded from brachytherapy, which I had never heard of before, because of the size of my prostate. I had to choose between external beam radiotherapy (EBRT) and radical prostatectomy (RP). How on Earth could I choose rationally while knowing so little about prostate cancer? However, I had studied maths and phy...
Source: The Health Care Blog - June 17, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized ADT Dutch Health Care System Gleason Prostate Prostate Cancer Sweden Source Type: blogs
Those Nasty Complications
I often wonder in cancer treatment, which is worse - treatment or complications? I think complications win that one. To me complications mean more doctor visits, more drugs, more expense, more whininess, and less happy results.In recent years, we have had the whats-her-name effect (this is what happens when you blog too early in the day) where women are getting bilateral and unilateral mastectomies at higher rates than in the past. There is no real proof that mastectomies are better than lumpectomies with radiation for early stage breast cancer but many women opt for them anyway.But there is a problem. New research (becaus...
Source: Caroline's Breast Cancer Blog - May 19, 2017 Category: Cancer & Oncology Tags: breast cancer treatment doctor appointments medical complications medical costs side effects Source Type: blogs
Elekta Introduces Unity, The First High-Field MR-Linac System
Elekta, the famous Swedish maker of radiation therapy, radiosurgery, and brachytherapy systems, is in the final stages of combining a linear accelerator therapy and magnetic resonance imaging scanner in one unified system. Many physicists and engineers thought that this would be impossible, as quickly moving charged particles shooting out of an accelerator are strongly affected by a magnetic field. But scientists at UMC Utrecht, a major research center in Holland, had some novel ideas and built the first prototype long ago, proving the skeptics wrong, and in the process convincing Elekta to work with Philips on developin...
Source: Medgadget - May 8, 2017 Category: Medical Devices Authors: Editors Tags: Radiation Oncology Radiology Source Type: blogs
Elekta Releases Unity, The First High-Field MR-Linac System
Elekta, the famous Swedish maker of radiation therapy, radiosurgery, and brachytherapy systems, is finally releasing a linear accelerator therapy and magnetic resonance imaging scanner in one unified system. Many physicists and engineers thought that this would be impossible, as quickly moving charged particles shooting out of an accelerator are strongly affected by a magnetic field. But scientists at UMC Utrecht, a major research center in Holland, had some novel ideas and built the first prototype long ago, proving the skeptics wrong, and in the process convincing Elekta to work with Philips on developing a commercial ...
Source: Medgadget - May 8, 2017 Category: Medical Devices Authors: Editors Tags: Radiation Oncology Radiology Source Type: blogs
Elekta Releases Unity, The First Commercial High-Field MR-Linac System
Elekta, the famous Swedish maker of radiation therapy, radiosurgery, and brachytherapy systems, is finally releasing a linear accelerator therapy and magnetic resonance imaging scanner in one unified system. Many physicists and engineers thought that this would be impossible, as quickly moving charged particles shooting out of an accelerator are strongly affected by a magnetic field. But scientists at UMC Utrecht, a major research center in Holland, had some novel ideas and built the first prototype long ago, proving the skeptics wrong, and in the process convincing Elekta to work with Philips on developing a commercial ...
Source: Medgadget - May 8, 2017 Category: Medical Equipment Authors: Editors Tags: Radiation Oncology Radiology Source Type: blogs
