Treatment of locally advanced cervical cancer in a patient with a bicornuate uterus with MRI-guided intracavitary/interstitial brachytherapy.
Conclusions: We found that the use of the hybrid applicator allowed for adequate target coverage in a patient with unusual anatomy. The patient tolerated treatment well and demonstrated favorable response on follow-up exam and imaging. The long-term curative result needs to be further evaluated. PMID: 31435436 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Treatment planning considerations for 125I eye plaque brachytherapy.
Authors: Miguel D, de Frutos JM, López-Lara F, Alonso P, Diezhandino P, Saornil MA, García C Abstract Effective cancer brachytherapy requires a treatment plan that delivers high-dose to tumor, while minimizing the dose to critical normal tissues. Therefore, an accurate knowledge of the sources and magnitude of the techniques is essential for producing robust and well optimized-plans. The purpose of this technical note is to establish general procedures and strategies for optimization and customization of the plaques loaded with radioactive seeds, particularly focusing on the definition of useful tacti...
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Hybrid optimization based on non-coplanar needles for brachytherapy dose planning.
Conclusions: The hybrid inverse optimization method achieved high conformity in the clinical practice. The non-coplanar needle can help to achieve a better dose distribution than the coplanar needle. PMID: 31435434 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Influence of dwell time homogeneity error weight parameter on treatment plan quality in inverse optimized high-dose-rate cervix brachytherapy using SagiPlan.
This study, for the first time, aims to quantify the impact of modulation restriction on plan quality indices in inverse optimization for cervix high-dose-rate (HDR) brachytherapy using the BEBIG SagiPlan treatment planning system. Material and methods: Ten cervical cancer patient plans were optimized for treatment with a BEBIG SagiNova 60Co HDR afterloader using the min/max inverse planning method, with dwell time homogeneity error weight (DTHEW) parameter values of 0 to 10. Dwell time homogeneity and gradients as well as various plan quality indices were analyzed. Results: For DTHEW = 0, min/max-based optimizatio...
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Image-guided high-dose-rate brachytherapy for prostate cancer patients with previous rectal resection and pelvic irradiation: feasibility study.
Conclusions: Fluoroscopy and 3D CT image-guided interstitial brachytherapy is feasible and appears to be a suitable treatment technique for patients with clinically localized prostate cancer after previous rectal resection and external beam radiation therapy. PMID: 31435432 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Fibre-optic endoscope-guided three-dimensional high-dose-rate interstitial brachytherapy for residual nasopharyngeal carcinoma after conventional external beam radiotherapy.
Conclusions: Fibre-optic endoscope-guided 3D HDR ISBT boost could be an additional treatment strategy for locoregional residual NPC after radical EBRT, especially for deep invasive lesion. PMID: 31435431 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Dosimetry verification of 3D-printed individual template based on CT-MRI fusion for radioactive 125I seed implantation in recurrent high-grade gliomas.
Conclusions: 3D-PIT based on the CT-MRI fusion images can result in good accuracy for positioning and dose distribution in radioactive seed implantation for treatment of rHGG. PMID: 31435430 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Single institution implementation of permanent 131Cs interstitial brachytherapy for previously irradiated patients with resectable recurrent head and neck carcinoma.
Conclusions: Cesium-131 interstitial brachytherapy is feasible and does not pose major radiation safety concerns; it should be considered as a treatment option for previously irradiated patients with recurrent, resectable HNC. PMID: 31435429 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Interstitial high-dose-rate brachytherapy in the primary treatment of inoperable glioblastoma multiforme.
Conclusions: For patients with inoperable GBM, IRT HDR BRT alone or in combination with EBRT is a safe and effective irradiation method providing palliation without excessive toxicity. PMID: 31435428 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

A prospective comparison of subjective and objective assessments of cosmetic outcomes following breast brachytherapy.
Authors: Wadasadawala T, Sinha S, Verma S, Parmar V, Kannan S, Pathak R, Sarin R, Gaikar M Abstract Purpose: We evaluated agreement between subjective and objective methods of cosmesis scoring in an accelerated partial breast irradiation (APBI) cohort. Material and methods: Consecutive women treated with APBI using interstitial brachytherapy reported for clinical follow-up every 6 months. Single cross-sectional assessment of the breast cosmesis was done by a radiation oncologist (subjective method) using Harvard scale and by photographic assessment using BCCT.core (Breast Cancer Conservative Treatment. Cosmetic...
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Whole-gland salvage treatment for recurrent prostate cancer after initial definitive radiotherapy: A case series of 125I brachytherapy and robot-assisted radical prostatectomy.
Conclusions: Whole-gland salvage BT is an effective treatment with an acceptable toxicity profile. The pathology findings from RARP imply that there is a room for improvement in diagnoses made by MRI in the pre-salvage setting. PMID: 31435426 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Prospective four years of evaluation of erectile function after low-dose-rate prostate brachytherapy using baseline IIEF-5 > 16.
Conclusions: During the first 4 years after BT, more than half of patients maintained an IIEF-5> 16, and EF results remained stable. Severe erectile dysfunction (ED) was very rare. PMID: 31435425 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Letter from the Editor-in-Chief.
Authors: Chicheł A PMID: 31435424 [PubMed] (Source: Journal of Contemporary Brachytherapy)
Source: Journal of Contemporary Brachytherapy - August 24, 2019 Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research

Current Role of Radiotherapy in Non-melanoma Skin Cancer
Non-melanoma skin cancer (NMSC) represents the most frequently diagnosed malignancy worldwide, most being cutaneous basal cell and squamous cell carcinoma. The global incidence of NMSC continues to increase as the global population ages. Numerous treatment options are available for NMSC patients, with radiotherapy an efficacious and tissue-preserving non-surgical option. External beam radiotherapy and brachytherapy are modalities with specific indications and advantages in treating NMSC. Where excision is not an option (medically/technically inoperable) or considered less ideal (e.g. (Source: Clinical Oncology)
Source: Clinical Oncology - August 22, 2019 Category: Radiology Authors: M.J. Veness, D. Delishaj, E.A. Barnes, A. Bezugly, A. Rembielak Tags: Overview Source Type: research

Acute and subacute radiation toxicities of high-dose-rate brachytherapy in patients with nonmelanoma facial skin cancers
In this study we evaluated the posttreatment radiation toxicity course associated with HDR-BT. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

First report of a phase IV study of electronic brachytherapy (EBx) in nonmelanoma skin cancer patients
Surgery, Doylestown, PA (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

A case of anogenital squamous cell carcinoma treated with high dose radiation brachytherapy
Background: Squamous cell carcinoma (SCC), however rare in the anogenital skin, is often locally aggressive. Development of anogenital SCC is related to several other dermatologic and related conditions, including condyloma, lichen planus, hidradenitis suppurativa, Crohn ’s disease, lichen sclerosis and immunosuppression of various etiologies. Even when lesions are detected early, surgical excision can be difficult due to the close proximity of other vital structures, and challenges with primary closure due to the paucity of excess tissue. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Rectal wall dose-volume effect of pre- or post KUSHEN Ningjiaos relationship with 3D brachytherapy in cervical cancer patients
The present prospective study evaluated the safety and efficacy of the rectum following KUSHEN Ningjiaos in cervical cancer. We compared rectal wall changes during brachytherapy with or without KUSHEN Ningjiaos i... (Source: Radiation Oncology)
Source: Radiation Oncology - August 20, 2019 Category: Cancer & Oncology Authors: Xiaojuan Li, Cheng Xiao, Yilin Kong, Weiwei Guo, Wenting Zhan, Gong Li, Xuetao Wang, Bailin Zhang and Lei Gao Tags: Research Source Type: research

Deployment and performance of model-based dose calculation algorithm in 192Ir shielded cylinder brachytherapy
The purpose of the study was to integrate model-based dose calculation algorithm (MBDCA) and 3-D planning into our institutional capabilities for clinical cases with inherent heterogeneities, namely shielded cylinder cases, which were previously performed using templates. (Source: Brachytherapy)
Source: Brachytherapy - August 20, 2019 Category: Cancer & Oncology Authors: Christopher J. Tien, Zhe (Jay) Chen Source Type: research

Experimental validation of a new COMS-like 24  mm eye plaque for the treatment of large ocular melanoma tumors
A new Collaborative Ocular Melanoma Study (COMS)-like 24  mm eye plaque was experimentally characterized using physical and dosimetric measurements in preparation for clinical usage. The new eye plaque will enable surgeons and radiation oncologists to accommodate patients who have larger ocular melanoma tumors. (Source: Brachytherapy)
Source: Brachytherapy - August 20, 2019 Category: Cancer & Oncology Authors: Sarah McCauley Cutsinger, Renae Forsman, Stephen Corner, Christopher L. Deufel Source Type: research

The association of intraprostatic calcifications and dosimetry parameters with biochemical control after permanent prostate implant
The objective of this study was to evaluate the impact of intraprostatic calcifications (IC) on long-term tumor control in patients treated with permanent implant prostate brachytherapy (PIPB). (Source: Brachytherapy)
Source: Brachytherapy - August 20, 2019 Category: Cancer & Oncology Authors: Eric Vigneault, Khaly Mbodji, Damien Carignan, Andr é-Guy Martin, Nelson Miksys, Rowan M. Thomson, Sylviane Aubin, Nicolas Varfalvy, Luc Beaulieu Source Type: research

Partial-Breast Irradiation: Review of Modern Trials
AbstractPurpose of ReviewFollowing partial mastectomy, whole-breast irradiation (WBI), delivered over 3 to 6  weeks, has been the standard adjuvant radiation approach for early-stage breast cancer. A growing body of literature over the past decade has suggested that irradiation of the partial breast, including the tumor bed plus a margin, may be a suitable alternative for appropriately selected patients. The use of partial breast irradiation (PBI) has been studied in multiple prospective randomized trials, now with up to 10 years of follow-up, establishing similar safety and efficacy compared with WBI. Advantages...
Source: Current Breast Cancer Reports - August 19, 2019 Category: Cancer & Oncology Source Type: research

How might financial pressures have impacted brachytherapy? A proposed narrative to explain the declines in cervical and prostate brachytherapy utilization
Rates of brachytherapy administration in the United States have declined for both cervical and prostate cancers, and we argue that the available facts suggest financial considerations are a major contributor to this issue. In this narrative, we discuss financial pressures that have existed for cervical and prostate brachytherapy and how they may have influenced their declining usage, consider other proposed influences, and provide suggestions for future research to understand the scope of the issue. (Source: Brachytherapy)
Source: Brachytherapy - August 19, 2019 Category: Cancer & Oncology Authors: Michael Schad, Roman Kowalchuk, Sushil Beriwal, Timothy N. Showalter Tags: Gynecologic Oncology Source Type: research

High efficacy of hypofractionated proton therapy with 4 fractions of 5  Gy as a boost to 50 Gy photon therapy for localized prostate cancer.
CONCLUSION: Dose escalation with hypofractionated proton boost was as effective as reported with high dose-rate brachytherapy boost, and the GU and GI toxicity profile was very similar. The proton boost was also appropriate for patients with larger prostate volume, higher T-stage, and high-risk disease encompassing elective regional node photon therapy. PMID: 31431382 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 17, 2019 Category: Radiology Authors: Johansson S, Isacsson U, Sandin F, Turesson I Tags: Radiother Oncol Source Type: research

Radiosensitization of high-grade gliomas through induced hyperthermia: Review of clinical experience and the potential role of MR-guided focused ultrasound.
Abstract High-grade gliomas (HGGs) are aggressive primary brain tumors that confer poor prognoses. Despite aggressive combined modality treatment, HGGs invariably recur. Considerable research efforts and resources have focused on identification of novel therapies for HGGs; however, standard treatments have not changed significantly in more than 10 years, since the introduction of concurrent chemoradiation therapy with temozolomide. Hyperthermia (HT) has been shown to enhance the efficacy of radiation treatment (RT) in numerous cancer types through multiple mechanisms, including impairment of DNA repair pathways,...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 17, 2019 Category: Radiology Authors: Schneider CS, Woodworth GF, Vujaskovic Z, Mishra MV Tags: Radiother Oncol Source Type: research

Long-term biochemical outcomes using cesium-131 in prostate brachytherapy
We report our institution's high-volume experience and the most mature data to date on outcomes with 131Cs prostate BT. (Source: Brachytherapy)
Source: Brachytherapy - August 16, 2019 Category: Cancer & Oncology Authors: Brian J. Moran, Stephanie R. Rice, Arpit M. Chhabra, Neha Amin, Michelle Braccioforte, Manuj Agarwal Source Type: research

Clinical Outcomes of Volumetric Modulated Arc Therapy Following Intracavitary/Interstitial Brachytherapy in Cervical Cancer: A Single Institution Retrospective Experience
Conclusion: VMAT combined with IC/IS BT can result in satisfactory curative outcomes and low incidences of late radiation enterocolitis and cystitis in CC treatment. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - August 16, 2019 Category: Cancer & Oncology Source Type: research

High ‐dose‐rate interstitial brachytherapy for a bulky sebaceous carcinoma of the eyelid: A case report
High ‐dose‐rate interstitial brachytherapy (HDR‐ISBT) achieved excellent local control of the bulky sebaceous carcinoma of the eyelid. However, we must pay attention to dose of eyelid and cornea about late toxicity of HDR‐ISBT. AbstractHigh ‐dose‐rate interstitial brachytherapy (HDR‐ISBT) achieved excellent local control of the bulky sebaceous carcinoma of the eyelid. However, we must pay attention to dose of eyelid and cornea about late toxicity of HDR‐ISBT. (Source: Clinical Case Reports)
Source: Clinical Case Reports - August 15, 2019 Category: General Medicine Authors: Yoshiaki Takagawa, Naoya Murakami, Shigenobu Suzuki, Fumihiko Matsumoto, Seiichi Yoshimoto, Jun Itami Tags: CASE REPORT Source Type: research

Interpretation of adverse reactions and complications in Chinese expert consensus of Iodine-125 brachytherapy for pancreatic cancer
This article aims at interpreting the adverse reactions and complications after the implantation of radioactive seeds. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - August 14, 2019 Category: Cancer & Oncology Authors: Qingchun Li Yun Liang Ye Zhao Baodong Gai Source Type: research

Feasibility of three-dimensional-printed template-guided 125I seed brachytherapy and dosimetric evaluation in patients with malignant tumor
Conclusion: For immobilized malignant tumors, 3D-printed template can be used reproducibly. The dose parameters in preplan can be achieved easily and satisfactorily by 3D-printed template guided brachytherapy, and it may become an easily reproducible standardized procedure in the future. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - August 14, 2019 Category: Cancer & Oncology Authors: Hongtao Zhang Devjoy Dev Huimin Yu Xuemin Di Yansong Liang Lijuan Zhang Xiaoli Liu Jinxin Zhao Zezhou Liu Aixia Sui Juan Wang Man Hu Source Type: research

Computed tomography-magnetic resonance imaging fusion-guided iodine-125 seed implantation for single malignant brain tumor: Feasibility and safety
Conclusions: CT-MRI image fusion is feasible for the design, optimization, and verification of treatment planning. CT-MRI fusion-based brachytherapy may improve dosimetry of brain tumor while sparing the normal structures, potentially impacting disease control, treatment-related toxicity, and long-term survival. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - August 14, 2019 Category: Cancer & Oncology Authors: Shi-Feng Liu Jian Lu Hong Wang Yan Han De-Feng Wang Li-Li Yang Zi-Xiang Li Xiao-Kun Hu Source Type: research

Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and Brachytherapy
Introduction: Definitive chemoradiotherapy (CRT) followed by high-dose-rate (HDR) brachytherapy (BT) is the state-of-the-art treatment for locally advanced (≥ FIGO IIb) cervical cancer but three-year survival rates are stagnating in recent years indicating the need for biomarker development and patient’s stratification. In the present study we aimed to analyse the predictive relevance of Polo-like kinase (PLK) 3 expression and levels of Caspase 8 T273 phosphorylation in patients with advanced cervical squamous cell carcinoma (CSCC) treated with CRT and BT. Methods: In a cohort of 74 patients with FIGO Stage Ib...
Source: Frontiers in Oncology - August 14, 2019 Category: Cancer & Oncology Source Type: research

Impact of combined selective internal radiation therapy and sorafenib on survival in advanced hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common type of malignant primary liver tumour, accounting for 80 –90% of all liver cancers. [1] In the USA, for example, 30,640 new liver and intrahepatic bile duct cancers are estimated to have occurred in 2013, with 21,670 associated deaths. [2–3] (Source: Journal of Hepatology)
Source: Journal of Hepatology - August 14, 2019 Category: Gastroenterology Authors: Jens Ricke, Heinz Josef Klumpen, Holger Amthauer, Irene Bargellini, Peter Bartenstein, Enrico de Toni, Antonio Gasbarrini, Maciej Pech, Markus Peck-Radosavljevic, Peter Popovi č, Olivier Rosmorduc, Eckart Schott, Max Seidensticker, Chris Verslype, Bruno Source Type: research

Salvage reirradiation for local prostate cancer recurrence after radiation therapy. For who? When? How?
CONCLUSION: Despite a lack of prospective data, salvage reirradiation for prostate cancer recurrence can be proposed to highly selected patients and tumours. Prospective comparative studies are needed. PMID: 31421999 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - August 14, 2019 Category: Cancer & Oncology Authors: Baty M, Créhange G, Pasquier D, Palard X, Deleuze A, Gnep K, Key S, Beuzit L, Castelli J, de Crevoisier R Tags: Cancer Radiother Source Type: research

Cancers, Vol. 11, Pages 1155: Hepatic Resection Following Selective Internal Radiation Therapy for Colorectal Cancer Metastases in the FOXFIRE Clinical Trial: Clinical Outcomes and Distribution of Microspheres
This study promotes the feasibility of hepatic resection following SIRT. Resin microspheres appear to preferentially distribute at the tumour periphery and may enhance tumour regression. (Source: Cancers)
Source: Cancers - August 12, 2019 Category: Cancer & Oncology Authors: Helen Winter Joseph Rassam Pradeep S. Virdee Rob Goldin Priyankaa Pitcheshwar Klara Weaver John Primrose David P. Berry Harpreet S. Wasan Ricky A. Sharma Tags: Article Source Type: research

Metastatic Mixed Adenoneuroendocrine Carcinoma of the Colon with Response to Immunotherapy with Pembrolizumab: A Case Report
We present the case of a 51-year-old female patient with histopathologically confirmed diagnosis of a MANEC of the descending colon. At presentation, the tumor had already spread to the liver causing extensive hepatic metastases. Immunohistochemical examination showed 5%–10% of tumor cells to express the programmed cell death receptor ligand 1 and FoundationOne testing revealed a high mutational tumor burden with 149 Muts/Mb. The patient responded very well clinically and radiologically to anti-programmed death 1 receptor monoclonal antibody pembrolizumab therapy after having undergone 3 previous systemic treatment r...
Source: Journal of Immunotherapy - August 9, 2019 Category: Allergy & Immunology Tags: Clincal Studies Source Type: research

Adjuvant treatment for endometrial cancer
This article reviews and interprets studies on adjuvant treatment of endometrial cancer published during the last 18 months. Recent findings For patients with intermediate and high intermediate risk endometrial cancer, vaginal brachytherapy remains the adjuvant therapy of choice. New molecular markers might help to define patients in this group for whom observation only is sufficient and women who might have benefitted from external beam radiotherapy. Preliminary results from large randomized controlled trials have shown that in early stage, high-risk endometrial cancer the addition of chemotherapy to external beam radi...
Source: Current Opinion in Oncology - August 9, 2019 Category: Cancer & Oncology Tags: GYNECOLOGIC CANCER: Edited by Jean A. Klastersky Source Type: research

Benefit of Cisplatin With Definitive Radiotherapy in Older Women With Cervical Cancer.
CONCLUSIONS: Administration of cisplatin with definitive RT in women aged ≥65 years was associated with a significant benefit in the incidence of death attributable to cervical cancer, despite competing risks for mortality in an older population. Receiving at least 5 cycles of weekly cisplatin was required for benefit. PMID: 31390586 [PubMed - in process] (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - August 8, 2019 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

An evaluation of gender diversity in the American Brachytherapy Society
The objective of this study is to assess trends in gender diversity in the ABS. (Source: Brachytherapy)
Source: Brachytherapy - August 8, 2019 Category: Cancer & Oncology Authors: Diana J. Lu, Michael Luu, Catheryn M. Yashar, Ann H. Klopp, Mitchell Kamrava Source Type: research

Salvage Re-irradiation With Single-modality Interstitial Brachytherapy for the Treatment of Recurrent Gynaecological Tumours in the Pelvis: A Multi-institutional Study
This study investigates the strategy of salvage single-modality interstitial brachytherapy (SM-ISBT) for recurrent gynaecological pelvic cancer at two specialised ISBT centres. (Source: Clinical Oncology)
Source: Clinical Oncology - August 8, 2019 Category: Radiology Authors: H. Raziee, D. D'Souza, V. Velker, E. Barnes, A. Taggar, L. Mendez, E. Leung Tags: Original Article Source Type: research

Dosimetric and radiobiological investigation of permanent implant prostate brachytherapy based on Monte Carlo calculations
Permanent implant prostate brachytherapy plays an important role in prostate cancer treatment, but dose evaluations typically follow the water-based TG-43 formalism, ignoring patient anatomy and interseed attenuation. The purpose of this study is to investigate advanced TG-186 model-based dose calculations via retrospective dosimetric and radiobiological analysis for a new patient cohort. (Source: Brachytherapy)
Source: Brachytherapy - August 7, 2019 Category: Cancer & Oncology Authors: Ali-Reza Mehan Haidari, Nelson Miksys, Paul Soubiran, Joanna Ewa Cygler, Oliver Holmes, Gad Perry, Rowan M. Thomson Source Type: research

[Reirradiations: Which decision-making criteria?]
nge G Abstract The decision to reirradiate a volume which had been previously irradiated remains in 2019 one of the most difficult challenge for a radiation oncologist. Such a decision has to be based on a number of clinical and technological criteria, and the radiation oncologist will have to answer three main questions: i) can the patient clinically tolerate a second irradiation in the same previously irradiated area? While waiting for fully reliable individual tests of radiosensitivity, one has to take into account the tolerance of the first irradiation, as well as the comorbidities and/or habits which could im...
Source: Cancer Radiotherapie - August 7, 2019 Category: Cancer & Oncology Authors: Cosset JM, Chargari C, Créhange G Tags: Cancer Radiother Source Type: research

Disparities Among Cervical Cancer Patients Receiving Brachytherapy.
Abstract OBJECTIVE: To evaluate the effects of race and insurance status on the use of brachytherapy for treatment of cervical cancer. METHODS: This is a retrospective cohort study of the National Cancer Database. We identified 25,223 patients diagnosed with stage IB2 through IVA cervical cancer who received radiation therapy during their primary treatment from 2004 to 2015. A univariate analysis was used to assess covariate association with brachytherapy. A multivariable regression model was used to evaluate the effect of race and insurance status on rates of brachytherapy treatment. The Cox proportional haz...
Source: Obstetrics and Gynecology - August 7, 2019 Category: OBGYN Authors: Bruce SF, Joshi TV, Chervoneva I, Yi M, Chatterjee-Paer S, Burton ER, Edelson MI, Sorosky JI, Shahin MS Tags: Obstet Gynecol Source Type: research

Cancers, Vol. 11, Pages 1124: Predicting Visual Acuity Deterioration and Radiation-Induced Toxicities after Brachytherapy for Choroidal Melanomas
. Kiilgaard Ruthenium-106 (Ru-106) brachytherapy is an established modality for eye-preserving treatment of choroidal melanoma. To achieve optimal treatment outcomes, there should be a balance between tumour control and the risk of healthy tissue toxicity. In this retrospective study, we examined normal tissue complication probability (NTCP) for visual acuity deterioration and late complications to aid the understanding of dose-dependence after Ru-106 treatments. We considered consecutive patients diagnosed with choroidal melanoma and primarily treated at a single institution from 2005–2014. Treatment pla...
Source: Cancers - August 6, 2019 Category: Cancer & Oncology Authors: Charlotte A. Espensen Ane L. Appelt Lotte S. Fog Anita B. Gothelf Juliette Thariat Jens F. Kiilgaard Tags: Article Source Type: research

Current treatment of pediatric bladder and prostate rhabdomyosarcoma (bladder preserving vs. radical cystectomy)
Purpose of review To discuss alternative strategies for multimodal treatments of nonmetastatic bladder–prostate rhabdomyosarcoma performed with the aim of preserving organ function. Recent findings Bladder–prostate rhabdomyosarcomas are seldom fully resectable at presentation or after induction chemotherapy, and extensive resection might not improve survival. When an organ-sparing approach is pursued, radiotherapy might be unavoidable to achieve reliable local control of the disease. Benefits of preoperative vs. postoperative radiotherapy have yet to be investigated. Multimodal treatments may often result ...
Source: Current Opinion in Urology - August 2, 2019 Category: Urology & Nephrology Tags: PAEDIATRIC URO-ONCOLOGY: Edited by Manuela P. Hiess Source Type: research

Predictors of quality of care and survival in a three-state cohort of locally advanced cervical cancer patients and development of a predictive model to identify women at risk of incomplete treatment
To expand our prior statewide analysis of care distribution for locally advanced cervical cancer in Virginia to include 2 more states and to develop a tool for predicting quality of care. Complete treatment was defined as receiving chemotherapy (CT), brachytherapy (BT), and external beam radiotherapy. State cancer registry databases yielded a three-state cohort of 3197 women diagnosed with locally advanced cervical cancer from 2000 to 2013. A logistic regression evaluated predictors for receipt of BT, CT, and high (2–3 modalities received) versus low (0–1 modalities received) quality care. A Cox proportional h...
Source: Medicine - August 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Patient-reported health-related quality of life up to three years after the treatment with permanent brachytherapy: Outcome of the large-scale, prospective longitudinal study in Japanese –Prostate Cancer Outcome Study by Permanent I-125 Seed Implantation (J-POPS)
To evaluate long-term health-related quality of life (HRQOL) impact of I-125 permanent seed implantation (PI) in Japanese patients with localized prostate cancer. (Source: Brachytherapy)
Source: Brachytherapy - August 1, 2019 Category: Cancer & Oncology Authors: Hirofumi Koga, Seiji Naito, Hiromichi Ishiyama, Atsunori Yorozu, Shiro Saito, Shinsuke Kojima, Satoshi Higashide, Takashi Kikuchi, Katsumasa Nakamura, Takushi Dokiya, Masanori Fukushima, the J-POPS Study Group Source Type: research

Prostatic Artery Embolization Obviates the Need for Androgen Deprivation Therapy prior to Stereotactic Body Radiation Therapy in Prostate Cancer
Prostatic artery embolization (PAE) is a safe and efficacious treatment for moderate to severe lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH) refractory to medical therapy, including those in patients with multiple comorbidities who are poor surgical candidates or have large prostates (>80 mL) (1). Stereotactic body radiation therapy (SBRT) delivers high-dose radiation over a short time course, providing prostate cancer treatment outcomes similar to those in conventional external beam radiation therapy (EBRT) or brachytherapy (2). (Source: Journal of Vascular and Interventional Radiology : JVIR)
Source: Journal of Vascular and Interventional Radiology : JVIR - August 1, 2019 Category: Radiology Authors: Diane Szaflarski, Miltiadis Tembelis, Aaron Katz, Jonathan Haas, Jason C. Hoffmann Tags: Letter to the Editor Source Type: research

A new fast algorithm to achieve the dose uniformity around high dose rate brachytherapy stepping source using Tikhonov regularization
AbstractThe dose optimization algorithm based on anatomical points is developed to produce rapidly uniform doses over target distances generated on the target volume edges in high-dose-rate (HDR) brachytherapy stepping source application for a treatment length of 6  cm. Monte Carlo modeling of the60Co HDR brachytherapy source and the surrounding medium were performed using PHITS code. The source dwell times were optimized using Tikhonov regularization in order to obtain uniform dose distribution at the anatomical points located at predefined target distances. The computed dose rates at distances from 0.25 up to 20 &nb...
Source: Australasian Physical and Engineering Sciences in Medicine - July 30, 2019 Category: Biomedical Engineering Source Type: research

Outcomes of intermediate-risk to high-risk stage I endometrial cancer: 10-year clinical experiences of using in-house multi-channel applicators in a single center.
CONCLUSIONS: For patients with IR to HR stage I EC, adjuvant VBT alone or in combination with EBRT using IH-MCA led to excellent survival and recurrence rates. Age and grade were the prognostic factors correlated with OS. PMID: 31365429 [PubMed - as supplied by publisher] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - July 30, 2019 Category: General Medicine Authors: Hou XR, Yu L, Hu K, Zhang FQ Tags: Chin Med J (Engl) Source Type: research