Increasing the efficiency of the retinoblastoma brachytherapy protocol with ultrasonic hyperthermia and gold nanoparticles: A rabbit model.
This study purposed to evaluate the efficacy of brachytherapy with the modality of ultrasonic hyperthermia in the presence of gold nanoparticles (GNPs) on an ocular retinoblastoma tumor in an animal model of the rabbit. MATERIALS AND METHODS: Gold nanoparticles (GNPs) were synthesized and confirmed by UV-vis spectroscopy, scanning electron microscopy and dynamic light scattering. Rabbit eyes were exposed to an ultrasonic continuous mode to reach 42 °C, and then turned into a pulse mode (40%) to maintain in the hyperthermia range (42-45 °C) for 30 min. For in vivo experiments, a retinoblasto...
Source: International Journal of Radiation Biology - October 22, 2020 Category: Radiology Tags: Int J Radiat Biol Source Type: research

Current Status of Anatomical Magnetic Resonance Imaging in Brachytherapy and External Beam Radiotherapy Planning and Delivery
Radiotherapy planning and delivery have dramatically improved in recent times. Imaging is key to a successful three-dimensional and increasingly four-dimensional based pathway with computed tomography embedded as the backbone modality. Computed tomography has significant limitations for many tumour sites where soft-tissue discrimination is suboptimal, and where magnetic resonance imaging (MRI) has largely superseded in the diagnostic arena. MRI is increasingly used together with computed tomography in the radiotherapy planning pathway and is now established as a prerequisite for several tumours. (Source: Clinical Oncology)
Source: Clinical Oncology - October 22, 2020 Category: Radiology Authors: M. Ingle, S. Lalondrelle Tags: Overview Source Type: research

Sol-gel-derived 58S bioactive glass containing holmium aiming brachytherapy applications: A dissolution, bioactivity, and cytotoxicity study
Publication date: February 2021Source: Materials Science and Engineering: C, Volume 119Author(s): Giulia Piagentini Delpino, Roger Borges, Telma Zambanini, Jhonny Frank Sousa Joca, Ivanise Gaubeur, Ana Carolina Santos de Souza, Juliana Marchi (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - October 21, 2020 Category: Materials Science Source Type: research

A guide to curriculum inquiry for brachytherapy simulation-based medical education
Brachytherapy is a required clinical competency within radiation oncology training but decreased utilization and volume have limited trainee exposure. Simulation-based medical education is an established educational tool that allows learners to engage in higher-order learning in a safe space and has unique application in brachytherapy instruction. (Source: Brachytherapy)
Source: Brachytherapy - October 21, 2020 Category: Cancer & Oncology Authors: Christian Fernandez, Jennifer Croke, Joanne Alfieri, Daniel W. Golden Source Type: research

Definitive radiotherapy consisting of whole pelvic radiotherapy with no central shielding and CT-based intracavitary brachytherapy for cervical cancer: feasibility, toxicity, and oncologic outcomes in Japanese patients
ConclusionsDefinitive RT consisting of noCS-WPRT and CT-based ICBT was feasible for Japanese patients with cervical cancer. To further improve LC, additional interstitial needles for patients with a large HR-CTV and shorter OTT should be considered. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 20, 2020 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 12, Pages 3059: EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma
Conclusions: PECp receiving exclusive brachytherapy with doses < 68Gy EQD2(α/β = 3Gy) at 2 cm2 of the vagina presented only G0–G1 vaginal toxicity, except for one with bleeding telangiectasias. Larger prospective studies are necessary to confirm the present results. (Source: Cancers)
Source: Cancers - October 20, 2020 Category: Cancer & Oncology Authors: Yaowen Zhang Balbino Fornes Gabriela G ómez Irene Bentoldr à Clara Carmona Antonio Herreros Sebasti à Sabater Inmaculada Nicol ás Yan Li Joan S ánchez Albert Biete Aureli Torn é Carlos Ascaso Ángeles Rovirosa Tags: Article Source Type: research

Matched-pair dosimetric comparison of cardiac radiation exposure between deep-inspiration breath-hold whole-breast radiation therapy with Active Breathing Coordinator and interstitial multicatheter high-dose-rate brachytherapy as accelerated partial breast irradiation in adjuvant treatment of left-sided breast cancer after breast-conserving surgery
ConclusionABC-WBRT and imHDR-APBI yield similar low heart and LV exposure for left-sided BCA after BCS, whereas LAD can be better spared with imHDR-APBI. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 19, 2020 Category: Cancer & Oncology Source Type: research

Accelerated Partial Breast Irradiation (APBI): Where Are We Now?
AbstractPurpose of ReviewAccelerated partial breast irradiation (APBI) is an alternative approach to breast conserving therapy (BCT) where radiation (RT) is delivered over a shorter period of time compared with whole breast irradiation (WBI), resulting in improved patient convenience and cost savings. APBI can be delivered using brachytherapy, intraoperative RT, or conformal external beam radiation therapy (EBRT) techniques. In this review, the authors appraise the latest modern randomized controlled trials (RCTs) of APBI and discuss the application of the data to clinical practice.Recent FindingsThe OCOG-RAPID and NSABP B...
Source: Current Breast Cancer Reports - October 18, 2020 Category: Cancer & Oncology Source Type: research

Efficacy of Surgical Excision and Brachytherapy in the Treatment of Keloids: A Retrospective Cohort Study
CONCLUSIONS Extralesional excision combined with postoperative high-dose-rate brachytherapy seems to be one of the most effective invasive protocols to treat and prevent keloids. (Source: Advances in Skin and Wound Care)
Source: Advances in Skin and Wound Care - October 17, 2020 Category: Dermatology Tags: ONLINE EXCLUSIVES Source Type: research

Anesthesia concerns in prostate brachytherapy: An institutional experience
Conclusions: CSE anesthesia is a safe and effective technique for anesthetic management of patients undergoing prostate brachytherapy. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - October 17, 2020 Category: Cancer & Oncology Authors: Vinod Kumar Deepti Ahuja Nishkarsh Gupta Sachidanand J Bharati Rakesh Garg Seema Mishra KP Haresh Subhash Gupta Sushma Bhatnagar Source Type: research

Outcomes of locally advanced cervical cancer presenting with obstructive uropathy: An institutional audit
Conclusion: Patients presenting with obstructive uropathy have median OS less than a year despite urinary diversion. Select cohort with good performance status, small tumor size, and serum creatinine of ≤3 mg/dL may be selected for diversion procedures and potential radical treatment. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - October 17, 2020 Category: Cancer & Oncology Authors: Rohan Salunkhe Supriya Chopra Suyash Kulkarni Nitin Shetty Reena Engineer Umesh Mahantshetty Jaya Ghosh Sudeep Gupta Shyam Kishore Shrivastava Source Type: research

Determining whether multiple needles are necessary in interstitial brachytherapy for thoracic tumors: A dosimetry analysis
Conclusions: Irregularly arranged multiple-needle interstitial brachytherapy does not provide superior doses to the lung, heart, spinal cord, or ribs compared with single-dwell-position plans. If regular arrangement of multiple needles is difficult to achieve, the multiple-needle scheme is not the only viable option. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - October 17, 2020 Category: Cancer & Oncology Authors: Bo Yang Xiaoyang Sun Haowen Pang Jingbo Wu Source Type: research

Assessing radiation oncology research needs in India: Results of a physician survey
Conclusions: With research training and mentorship, there is a greater likelihood that concepts and written protocols will translate into successfully completed studies in radiation therapy. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - October 17, 2020 Category: Cancer & Oncology Authors: Rohini Kishor Bhatia Supriya Sastri (Chopra) Vijay Anand Reddy Palkonda GV Giri Surendranath Senapati Ramesh S Bilimagga Manjeet Chadha Akila N Viswanathan Surbhi Grover Source Type: research

Multifocal Intraretinal Tumour Deposits following Treatment of an Ipsilateral Choroidal Melanoma
Conclusion: Retinoinvasive melanoma is a rare subtype of uveal melanoma, characterised by transvitreal melanoma invasion of the retina at a site non-contiguous with the uveal tumour, which may explain the clinical and pathological findings of the reported case.Ocul Oncol Pathol (Source: Ocular Oncology and Pathology)
Source: Ocular Oncology and Pathology - October 16, 2020 Category: Opthalmology Source Type: research

Evolving Brachytherapy Boost in Prostate Cancer in the Era of Hypofractionation
Radiation therapy (RT) for localized prostate cancer (PCa) has seen a rapid evolution of options to now include conventional fractionation, moderate and ultra-hypofractionation, and brachytherapy (BT) ± supplemental external beam RT (EBRT), in conjunction with risk-based use of androgen deprivation therapy (ADT). This variety gives wide latitude to physicians and patients to select modalities best suited to their preferences, resources, and medical context while achieving largely equitable end r esults. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 16, 2020 Category: Radiology Authors: Neil B. Desai, Aurelie Garant, Raquibul Hannan, Michael R. Folkert Tags: Clinical Investigation Source Type: research

Cardiac doses of accelerated partial breast irradiation with perioperative multicatheter interstitial brachytherapy
ConclusionPerioperative MIB-APBI resulted in low cardiac doses in our study. This finding provides further support for the value of this technique in well-selected patients with early-stage left breast cancer. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - October 16, 2020 Category: Cancer & Oncology Source Type: research

Salvage low dose rate brachytherapy for prostate cancer recurrence following definitive external beam radiation therapy
Intraprostatic local failure following primary external beam radiation therapy (RT) for prostate cancer remains a challenging clinical scenario. While multiple local therapy options have been proposed, no treatment has emerged as standard owing largely to concerns regarding increased toxicity and poor outcomes [1 –5]. As a result, many are unfortunately relegated to life-long androgen deprivation therapy (ADT), which is exclusively palliative in nature and itself bears substantial morbidity [6–8]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 16, 2020 Category: Radiology Authors: William H. Smith, Jamie Cesaretti, Chih Peng Chin, Mitchell Terk, Richard G. Stock Tags: Original Article Source Type: research

Patient-reported functional outcomes following external beam radiation therapy for prostate cancer with and without a high-dose rate brachytherapy boost: a national population-based study
Advances in radiotherapy planning and treatment have allowed for higher doses to be delivered to the prostate without leading to worse treatment safety or tolerability [1]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 16, 2020 Category: Radiology Authors: Matthew G. Parry, Julie Nossiter, Thomas E. Cowling, Arunan Sujenthiran, Brendan Berry, Paul Cathcart, Noel W. Clarke, Heather Payne, Jan van der Meulen, Ajay Aggarwal Tags: Original Article Source Type: research

Patient-reported functional outcomes following external beam radiation therapy for prostate cancer with and without a high-dose rate brachytherapy boost: a national population-based study.
CONCLUSIONS: There is no evidence to suggest that EBRT-BB results in any clinically important detriment in functional outcomes or HRQoL compared to men receiving EBRT only. Whilst statistically significantly worse urinary irritation/obstruction outcomes were reported in the EBRT-BB cohort, the threshold for a clinically significant difference was not exceeded and further research is required for confirmation. PMID: 33075390 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 16, 2020 Category: Radiology Authors: Parry MG, Nossiter J, Cowling TE, Sujenthiran A, Berry B, Cathcart P, Clarke NW, Payne H, van der Meulen J, Aggarwal A Tags: Radiother Oncol Source Type: research

Salvage low dose rate brachytherapy for prostate cancer recurrence following definitive external beam radiation therapy.
CONCLUSIONS: Salvage LDR brachytherapy is safe and efficacious, with acceptable grade 3+ toxicity and good biochemical control on long-term follow-up. Patients with higher grade group and higher PSA at initial diagnosis may be at increased risk for biochemical failure. PMID: 33075391 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 16, 2020 Category: Radiology Authors: Smith WH, Cesaretti J, Peng Chin C, Terk M, Stock RG Tags: Radiother Oncol Source Type: research

125I Seed Brachytherapy Combined with Single-Agent Chemotherapy in the Treatment of Non-Small-Cell Lung Cancer in the Elderly: A Valuable Solution
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - October 15, 2020 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research

Feasibility of removable balloon implant for simultaneous magnetic nanoparticle heating and HDR brachytherapy of brain tumor resection cavities.
CONCLUSIONS: These preclinical results demonstrate the feasibility of using a TBT balloon to deliver heat simultaneously with HDR brachytherapy to tumor bed around a brain tumor resection cavity, with significantly improved uniformity of heating over previous multi-catheter interstitial approaches. Considered along with results of previous clinical thermobrachytherapy trials, this new capability is expected to improve both survival and quality of life in patients with glioblastoma multiforme. PMID: 33047639 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 15, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Adapting to ensure brachytherapy remains a vital component of our future
For more than a century, brachytherapy has been a vital component of cancer treatment. Unfortunately, in recent years, this valuable technique has seen a notable decline in utilization. Competing treatment modalities and lack of robust training are in part to blame, leaving in-training and early career radiation oncologists unequipped to perform and retain the skills required to execute a variety of complicated brachytherapy procedures. To increase physician confidence with and subsequently mitigate underuse of this important modality, innovative educational methodologies are more essential than ever. (Source: Brachytherapy)
Source: Brachytherapy - October 15, 2020 Category: Cancer & Oncology Authors: Eric D. Donnelly Tags: Editorial Source Type: research

Evaluation of a collapsed-cone convolution algorithm for esophagus and surface mold 192Ir brachytherapy treatment planning
TG43 does not account for a lack of scatter and tissue and applicator heterogeneities. The advanced collapsed-cone engine (ACE) algorithm available for use in the Oncentra Brachy treatment planning system (Elekta AB, Stockholm, Sweden) can model these conditions more accurately and is evaluated for esophageal and surface mold brachytherapy treatments. (Source: Brachytherapy)
Source: Brachytherapy - October 15, 2020 Category: Cancer & Oncology Authors: Luke Eason, Josh Mason, Rachel Cooper, Ganesh Radhakrishna, Peter Bownes Source Type: research

Dose-Volume Effects and Risk Factors for Late Diarrhea in Cervix Cancer Patients after Radiochemotherapy with Image-Guided Adaptive Brachytherapy in the EMBRACE I Study
To evaluate patient- and treatment-related risk factors associated with incidence and persistence of late diarrhea after radiochemotherapy and image-guided adaptive brachytherapy in Locally Advanced Cervical Cancer. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - October 14, 2020 Category: Radiology Authors: Nina Boje Kibsgaard Jensen, Richard P ötter, Sofia Spampinato, Lars Ulrik Fokdal, Cyrus Chargari, Jacob Christian Lindegaard, Maximilian Schmid, Alina Sturdza, Ina Maria Jürgenliemk-Schulz, Umesh Mahantshetty, Barbara Segedin, Kjersti Bruheim, Peter Hos Source Type: research

Effect of adding androgen deprivation therapy to permanent iodine-125 implantation with or without external beam radiation therapy on the outcomes in patients with intermediate-risk prostate cancer: A propensity score –matched analysis11ADT, androgen deprivation therapy; ASCENDE-RT, Androgen Suppression Combined with Elective Nodal and Dose Escalated Radiation Therapy; BED, biological effective dose; bFFR, biochemical failure-free rate; bFFS, biochemical failure-free survival; BT, brachytherapy; EBRT, external beam radiation therapy; CI, confidence interval; CT, computed tomography; CVD, cardiovascular disease; GS, Gleason score; IQR, interquartile range; HR, hazard ratio; LRFR, local recurrence-free rate; MVA, multivariate analysis; NCCN, National Comprehensive Cancer Network; OS, overall survival; PET, positron emission tomography; PSA, prostate-specific antigen; PSM, propensity score matching; TTMB, transperineal template-guided mapping biopsy; UVA, univariate analysis.
The purpose of the study was to evaluate the effect of adding androgen deprivation therapy (ADT) to brachytherapy with or without external beam radiation therapy on oncological outcomes in prostate cancer. (Source: Brachytherapy)
Source: Brachytherapy - October 14, 2020 Category: Cancer & Oncology Authors: Shinya Sutani, Atsunori Yorozu, Kazuhito Toya, Yutaka Shiraishi, Toru Nishiyama, Yasuto Yagi, Ken Nakamura, Shiro Saito Source Type: research

Comparison of outcomes using radiotherapy or brachytherapy after  resection of primary adenoid cystic carcinoma in oral and maxillofacial regions
We wished to investigate the outcome of surgery combined with external-beam radiotherapy (EBRT) or brachytherapy (125I seeds) for the treatment of primary adenoid cystic carcinoma (ACC) of the oral and maxillofacial region. Data of patients with primary ACC were reviewed retrospectively. Patients were divided into EBRT and brachytherapy groups. Wide tumor excision was done to achieve negative margins. Standard radiotherapy in the EBRT group was 60  Gy. A treatment-planning system was used to create implantation plans with a prescribed dose of 60–120 Gy and 125I seeds were implanted postoperatively. (Source: Brachytherapy)
Source: Brachytherapy - October 14, 2020 Category: Cancer & Oncology Authors: C. Li, S.M. Liu, L. Zheng, M.W. Huang, Y. Shi, X.M. Lv, J.G. Zhang, X. Peng, J. Zhang Source Type: research

The role of brachytherapy for margin control in oral tongue squamous cell carcinoma
The aim of this study is to assess the feasibility and effectiveness of using peri-operative brachytherapy (BRTx) for positive/narrow margins present post primary surgical resection of oral tongue squamous cel... (Source: Journal of Otolaryngology - Head and Neck Surgery)
Source: Journal of Otolaryngology - Head and Neck Surgery - October 14, 2020 Category: ENT & OMF Authors: Ilia Ianovski, Alex M. Mlynarek, Martin J. Black, Boris Bahoric, Khalil Sultanem and Michael P. Hier Tags: Original research article Source Type: research

Ureteral Stenosis after 3D MRI-based Brachytherapy for Cervical Cancer – Have We Identified All the Risk Factors?
Cervical cancer is the fourth most common cancer in women worldwide and the primary cause of cancer-related deaths among women in low- and middle-income countries [1]. Chemoradiation followed by brachytherapy (BT) boost is the standard of care for patients with node-positive and/or locally advanced cervical cancer [2-5]. In the last few decades, there has been an evolution of BT planning from 2-dimensional (2D) point-based prescribing to 3-dimensional (3D)-computed tomography (CT) and most recently, magnetic resonance imaging (MRI)-based techniques [6]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 13, 2020 Category: Radiology Authors: Joshua L. Rodr íguez-López, Diane C. Ling, Andrew Keller, Hayeon Kim, Adrianna E. Mojica-Márquez, Scott M. Glaser, Sushil Beriwal Tags: Original Article Source Type: research

Patient-reported outcomes after external beam radiotherapy versus brachytherapy for palliation of dysphagia in esophageal cancer: a matched comparison of two prospective trials
A matched comparison of external beam radiotherapy (EBRT) versus brachytherapy recently demonstrated that EBRT appears at least as effective for palliating dysphagia in patients with incurable esophageal cancer. The aim of this analysis was to compare patient-reported outcomes (PROs) after EBRT versus brachytherapy. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 13, 2020 Category: Radiology Authors: Peter S.N. van Rossum, Paul M. Jeene, Tom Rozema, P ètra M. Braam, Irene M. Lips, Karin Muller, Daphne van Kampen, Bram D. Vermeulen, Marjolein Y.V. Homs, Vera Oppedijk, Maaike Berbée, Maarten C.C.M. Hulshof, Peter D. Siersema, Sherif Y. El Sharouni Tags: Original Article Source Type: research

Importance of the ICRU Bladder point dose on incidence and persistence of urinary frequency and incontinence in locally advanced cervical cancer: an EMBRACE analysis
Late morbidity after pelvic radiotherapy includes urinary side effects which may significantly impact patients quality of life (QoL) [1]. For locally advanced cervical cancer (LACC), the introduction of image-guided adaptive brachytherapy (IGABT) has led to a decrease in side effects compared to two-dimensional brachytherapy (BT) [2,3]. Disease control and overall survival are improved [4], but urinary morbidity still represents a burden for cancer survivors [5]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 13, 2020 Category: Radiology Authors: Sofia Spampinato, Lars U. Fokdal, Richard P ötter, Christine Haie-Meder, Jacob C. Lindegaard, Maximilian P. Schmid, Alina Sturdza, Ina M. Jürgenliemk-Schulz, Umesh Mahantshetty, Barbara Segedin, Kjersti Bruheim, Peter Hoskin, Bhavana Rai, Fleur Huang, R Tags: Original Article Source Type: research

Ureteral Stenosis after 3D MRI-based Brachytherapy for Cervical Cancer - Have We Identified All the Risk Factors?
ser SM, Beriwal S Abstract BACKGROUND AND PURPOSE: Ureteral stenosis (US) is a known complication from image-guided brachytherapy (IGBT); however, no dosimetric parameter has been associated with ureteral toxicity. We aimed to report the rate of late grade ≥3 US after MRI-based IGBT, and to identify clinical factors and dosimetric parameters predictive for US. MATERIALS AND METHODS: A retrospective review was performed on all cervical cancer patients treated with MRI-based IGBT between 2007-2017. Late grade ≥3 US was recorded according to CTCAE 4.03. The minimum dose to the maximally irradiated 0.1 cm3 ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 13, 2020 Category: Radiology Authors: Rodríguez-López JL, Ling DC, Keller A, Kim H, Mojica-Márquez AE, Glaser SM, Beriwal S Tags: Radiother Oncol Source Type: research

Importance of the ICRU Bladder point dose on incidence and persistence of urinary frequency and incontinence in locally advanced cervical cancer: an EMBRACE analysis.
CONCLUSION: ICRU-BP dose, in addition to clinical parameters, is a risk factor for urinary incontinence and shows a dose-effect after radio(chemo)therapy and IGABT. ICRU-BP dose should be monitored during treatment planning alongside volumetric parameters. Frequency seems associated with larger irradiated volumes. PMID: 33065183 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 13, 2020 Category: Radiology Authors: Spampinato S, Fokdal LU, Pötter R, Haie-Meder C, Lindegaard JC, Schmid MP, Sturdza A, Jürgenliemk-Schulz IM, Mahantshetty U, Segedin B, Bruheim K, Hoskin P, Rai B, Huang F, Cooper R, van der Steen-Banasik E, Van Limbergen E, Sundset M, Westerveld H, Nou Tags: Radiother Oncol Source Type: research

Patient-reported outcomes after external beam radiotherapy versus brachytherapy for palliation of dysphagia in esophageal cancer: a matched comparison of two prospective trials.
CONCLUSION: Short course EBRT results in similar or better PROs at 3 months after treatment compared to single-dose brachytherapy for the palliation of malignant dysphagia. These findings further support its use and inclusion in clinical practice guidelines. PMID: 33065190 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 13, 2020 Category: Radiology Authors: van Rossum PSN, Jeene PM, Rozema T, Braam PM, Lips IM, Muller K, van Kampen D, Vermeulen BD, Homs MYV, Oppedijk V, Berbée M, C C M Hulshof M, Siersema PD, El Sharouni SY Tags: Radiother Oncol Source Type: research

Long-term outcomes of a prospective randomized trial of 131Cs/125I permanent prostate brachytherapy
Iodine-125 (125I) is the most commonly used isotope for prostate brachytherapy (BT). Cesium-131 (131Cs) has a higher dose rate and shorter dose delivery time resulting in decreased duration of acute urinary morbidity. Long-term data suggest excellent oncologic outcomes; it is not known how outcomes compare. A prospective randomized trial comparing the two isotopes was initiated. (Source: Brachytherapy)
Source: Brachytherapy - October 12, 2020 Category: Cancer & Oncology Authors: Brian J. Moran, Antony Koroulakis, Cristina Decesaris, Michelle H. Braccioforte, Neha Amin, Manuj Agarwal Source Type: research

Adjuvant radiotherapy for endometrial cancer with cervical stromal involvement: A patterns of practice survey in Australia and New Zealand
ConclusionThis patterns of practice survey suggests variability in adjuvant radiotherapy recommendations in endometrial cancer with cervical involvement, particularly in cases where there is lack of randomised data and discrepancies in consensus guidelines. (Source: Journal of Medical Imaging and Radiation Oncology)
Source: Journal of Medical Imaging and Radiation Oncology - October 11, 2020 Category: Radiology Authors: Carminia Lapuz, Geetha Govindarajulu, Mark Tacey, Adeline Lim, Carol Johnson Tags: Radiation Oncology —Original Article Source Type: research

Cancers, Vol. 12, Pages 2899: Senescence-Associated Secretory Phenotype Determines Survival and Therapeutic Response in Cervical Cancer
mande Jin-Xiong She Molecular biomarkers that can predict survival and therapeutic outcome are still lacking for cervical cancer. Here we measured a panel of 19 serum proteins in sera from 565 patients with stage II or III cervical cancer and identified 10 proteins that have an impact on disease specific survival (DSS) (Hazzard’s ratio; HR = 1.51–2.1). Surprisingly, all ten proteins are implicated in senescence-associated secreted phenotype (SASP), a hallmark of cellular senescence. Machine learning using Ridge regression of these SASP proteins can robustly stratify patients with high SASP...
Source: Cancers - October 9, 2020 Category: Cancer & Oncology Authors: Sharad Purohit Wenbo Zhi Daron G. Ferris Manual Alverez Lynn Kim Hoang Tran Paul Minh Huy Tran Boying Dun Diane Hopkins Bruno dos Santos Sharad Ghamande Jin-Xiong She Tags: Article Source Type: research

Use of an ultrasound imaging device within the applicator to evaluate placement and support treatment planning for breast brachytherapy and intraoperative radiation therapy
We evaluated the use of ultrasound imaging within a brachytherapy applicator as a method for applicator positioning, evaluation, and treatment planning in a series of in  vitro, cadaver, and human studies. (Source: Brachytherapy)
Source: Brachytherapy - October 8, 2020 Category: Cancer & Oncology Authors: S. Unnikrishnan, D.R. Brenin, G. Suralik, T.N. Showalter, V. Shami, B. Libby, W.T. Watkins, S.L. Showalter, F. Zhao, S. Govinahallisathyanarayana, J.A. Hossack Source Type: research

Functional results of exclusive interventional radiotherapy (brachytherapy) in the treatment of nasal vestibule carcinomas
Surgery, external beam radiotherapy (EBRT), and interventional radiotherapy (IRT, BrachyTherapy BT) are the current therapeutic options for nose vestibule (NV) squamous cell carcinoma (SCC). In this article, we evaluate the nose functional parameters of patients affected by SCCs of the NV, primarily treated by interstitial IRT comparing them with healthy controls and with patients treated with intensity-modulated EBRT. (Source: Brachytherapy)
Source: Brachytherapy - October 8, 2020 Category: Cancer & Oncology Authors: Francesco Bussu, Luca Tagliaferri, Eugenio De Corso, Giulio Cesare Passali, Valentina Lancellotta, Gian Carlo Mattiucci, Maria Antonietta Gambacorta, Davide Rizzo, Giovanni Di Cintio, Antonio Salvati, Gaetano Paludetti, Vincenzo Valentini, Jacopo Galli Source Type: research

Radiation protection and dosimetry issues for patients with prostate cancer after I-125 low-dose-rate brachytherapy permanent implant
The aim of this work was to analyze the exposure rates measured in the proximity of patients who underwent prostate low-dose-rate brachytherapy with I-125 implant. Effective doses to relatives and to population were computed to estimate the time to reach radioprotection dose constraints. (Source: Brachytherapy)
Source: Brachytherapy - October 8, 2020 Category: Cancer & Oncology Authors: Tiziana Licciardello, Giacomo Feliciani, Giorgio Mazzotti, Domiziano Mostacci, Anna Sarnelli, Enrico Menghi Source Type: research

Accuracy of dwell-position detection with a combined electromagnetic tracking brachytherapy system for treatment verification in pelvic brachytherapy.
Abstract BACKGROUND AND PURPOSE: To investigate the accuracy of dwell position detection with a combined electromagnetic tracking (EMT) brachytherapy (BT) system for treatment verification, by quantifying positional errors due to EM field interference in typical pelvic BT clinical settings. MATERIALS AND METHODS: Dedicated prostate and cervix BT phantoms were imaged with CT. For the cervix phantom, the Utrecht applicator + interstitial catheters were used. The implants were reconstructed and treatment plans were created with 270/65 dwell positions for the prostate/cervix phantom. Next, EMT experiments were pe...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 7, 2020 Category: Radiology Authors: van Heerden L, Schiphof-Godart J, Christianen M, Mens JW, Franckena M, Maenhout M, Hoogeman M, Kolkman-Deurloo IK Tags: Radiother Oncol Source Type: research

Accuracy of dwell-position detection with a combined electromagnetic tracking brachytherapy system for treatment verification in pelvic brachytherapy
High dose-rate (HDR) brachytherapy (BT) is commonly used to treat prostate and cervical cancer by irradiating the target volume using dedicated applicators and/or catheters. BT offers sharp dose gradients which may lead to decreased dose to organs at risk compared to external beam radiotherapy.[1,2] Image-guided implant reconstruction has become standard practice, using medical imaging such as CT, MR or ultrasound acquired before treatment planning.[3,4] After reconstructing the applicator and/or interstitial catheters, a treatment plan is created using the target and organ at risk delineations by optimizing dwell times in...
Source: Radiotherapy and Oncology - October 6, 2020 Category: Radiology Authors: Laura van Heerden, J érémy Schiphof-Godart, Miranda Christianen, Jan-Willem Mens, Martine Franckena, Metha Maenhout, Mischa Hoogeman, Inger-Karine Kolkman-Deurloo Tags: Original Article Source Type: research

Comparison of perfused volume segmentation between cone-beam CT and 99mTc-MAA SPECT/CT for treatment dosimetry before selective internal radiation therapy using 90Y-glass microspheres
Publication date: Available online 5 October 2020Source: Diagnostic and Interventional ImagingAuthor(s): M. Martin, A. Hocquelet, F. Debordeaux, L. Bordenave, J.-F. Blanc, P. Papadopoulos, B. Lapuyade, H. Trillaud, J.-B. Pinaquy (Source: Diagnostic and Interventional Imaging)
Source: Diagnostic and Interventional Imaging - October 6, 2020 Category: Radiology Source Type: research

Robotic radical hysterectomy for cervical adenocarcinoma after preoperative brachytherapy in 10 steps
Publication date: Available online 6 October 2020Source: Journal of Minimally Invasive GynecologyAuthor(s): Pierre-Emmanuel Colombo, Van-Ha Nguyen, Christophe Taoum, Anne Mourregot, Mathias Neron, Christine Kerr, Philippe Rouanet, Guillaume Carrier (Source: Journal of Minimally Invasive Gynecology)
Source: Journal of Minimally Invasive Gynecology - October 6, 2020 Category: OBGYN Source Type: research

Robotic radical hysterectomy for cervical adenocarcinoma after preoperative brachytherapy in 10 steps
Minimally invasive surgery (MIS) decreases postoperative morbidity after radical hysterectomy (RH) for early-stage cervical cancer. However, a randomized trial and large retrospective data question its safety after observing lower rates of survival than open surgery [1,2]. The causes of this higher recurrence rate are not definitely established but may result from cancer exposure to peritoneum during vaginal section and cancerous-cells spillage enhanced by pneumoperitoneum or uterine manipulator. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 4, 2020 Category: OBGYN Authors: Pierre-Emmanuel Colombo, Van-Ha Nguyen, Christophe Taoum, Anne Mourregot, Mathias Neron, Christine Kerr, Philippe Rouanet, Guillaume Carrier Tags: Video Article Source Type: research

Simple phantom fabrication for MRI-based HDR brachytherapy applicator commissioning.
Abstract A new high dose rate (HDR) brachytherapy program was initiated in a community hospital setting, with the goal of using magnetic resonance (MR) images with the implant in place during the planning process. Physics acceptance testing and commissioning was completed for key program components, including multiple applicators. To image new applicators for MRI-based planning prior to use with patients, agar gel doped with copper sulfate was created using simple, MR-safe household materials as a practical and inexpensive alternative to custom-machined precision phantoms. Applicators in-phantom were scanned in a ...
Source: Journal of Applied Clinical Medical Physics - October 4, 2020 Category: Physics Authors: Fagerstrom JM, Kaur S Tags: J Appl Clin Med Phys Source Type: research

Clinical Presentations and Outcomes of Retinoblastoma Patients in relation to the Advent of New Multimodal Treatments: A 12-Year Report from Single Tertiary Referral Institute in Thailand.
Conclusions: Recent advanced treatment modalities have improved the probability of globe salvage. However, enucleation remains an important life-saving intervention in many advanced cases. PMID: 33005446 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - October 3, 2020 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Urine in the lung: An uncommon cause of transudative pleural effusion.
Abstract Urinothorax [UT], the accumulation of urine in the pleural space, is an uncommon cause of pleural effusions resulting from trauma, obstruction, or iatrogenic causes. Thoracentesis with pleural fluid analysis and evaluation of biochemical characteristics, such as pleural fluid creatinine (PCr) to serum creatinine ratio (Scr), is necessary to establish this diagnosis. This case illustrates a 93 year old man with a complicated past medical history including chronic kidney disease stage 4, adenocarcinoma of the prostate status post brachytherapy complicated by proctitis, high grade transitional cell carcinoma...
Source: Respiratory Care - October 3, 2020 Category: Respiratory Medicine Authors: Sullivan A, Lanham T, Bohra N, Ellis B, Kahn D Tags: Respir Med Case Rep Source Type: research

PIVOTALboost: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost (CRUK/16/018).
Abstract •PIVOTALboost evaluates benefits/toxicity of pelvic node RT and focal boost dose escalation.•Unfavourable intermediate/high risk and bulky local disease are most likely to benefit.•Functional MRI imaging is used to select patients for different types of dose escalation.•HDR brachytherapy or focal dose escalation with IMRT are used as options.•Training and support is provided to reduce variations of contouring and radiotherapy planning.•The trial is recruiting patients in 38 radiotherapy centres through the UK. PMID: 32995575 [PubMed] (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - October 2, 2020 Category: Cancer & Oncology Authors: Syndikus I, Cruickshank C, Staffurth J, Tree A, Henry A, Naismith O, Mayles H, Snelson N, Hassan S, Brown S, Porta N, Griffin C, Hall E Tags: Clin Transl Radiat Oncol Source Type: research

Differences in treatment choices for localised prostate cancer diagnosed in private and public health services.
CONCLUSION: Prostate cancer treatment choices differ substantially between men diagnosed in private and public health services in Victoria. These differences are not explained by disease severity or comorbidity. PMID: 32996611 [PubMed - as supplied by publisher] (Source: Medical Journal of Australia)
Source: Medical Journal of Australia - October 2, 2020 Category: General Medicine Tags: Med J Aust Source Type: research