Prostate-specific antigen kinetics and biochemical control following stereotactic body radiation therapy, high dose rate brachytherapy, and low dose rate brachytherapy: A multi-institutional analysis of 3,502 patients
Multiple forms of definitive radiotherapy are acceptable alternatives to more prolonged radiotherapy regimens for men with intermediate-risk prostate cancer (PCa) and can be considered for men with low-risk disease who decline active surveillance.[1] Stereotactic body radiotherapy (SBRT) is an external beam radiotherapy modality in which large radiation doses are delivered over five or fewer fractions. Two forms of brachytherapy -- permanent seed implant low dose rate brachytherapy (LDR-BT) and temporary interstitial implant high dose rate brachytherapy (HDR-BT) -- are also options. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - July 11, 2020 Category: Radiology Authors: Rebecca Levin-Epstein, Ryan R. Cook, J. Karen Wong, Richard G. Stock, D. Jeffrey Demanes, Sean P. Collins, Nima Aghdam, Simeng Suy, Constantine Mantz, Alan J. Katz, Nicholas G. Nickols, Leszek Miszczyk, Aleksandra Napieralska, Agnieszka Namysl-Kaletka, Ni Tags: Original Article Source Type: research

Fast interactive medical image segmentation with weakly supervised deep learning method
ConclusionsWe proposed and evaluated a fast, interactive deep learning method for accurate medical image segmentation. Moreover, our approach has the potential to solve the bottleneck of deep learning methods in adapting to inter-clinical variations and speed up the annotation processes. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - July 11, 2020 Category: Intensive Care Source Type: research

Development and execution of a pandemic preparedness plan: Therapeutic medical physics and radiation dosimetry during the COVID-19 crisis.
Abstract The SARS-CoV-2 coronavirus pandemic has spread around the world including the United States. New York State has been hardest hit by the virus with over 380 000 citizens with confirmed COVID-19, the illness associated with the SARS-CoV-2 virus. At our institution, the medical physics and dosimetry group developed a pandemic preparedness plan to ensure continued operation of our service. Actions taken included launching remote access to clinical systems for all dosimetrists and physicists, establishing lines of communication among staff members, and altering coverage schedules to limit on-site presence...
Source: Journal of Applied Clinical Medical Physics - July 11, 2020 Category: Physics Authors: Riegel AC, Chou H, Baker J, Antone J, Potters L, Cao Y Tags: J Appl Clin Med Phys Source Type: research

A prospective study of oral 5-aminolevulinic acid to prevent adverse events in patients with localized prostate cancer undergoing low-dose-rate brachytherapy: Protocol of the AMBER study.
Discussion: The goal of this trial is to determine the potential benefit of ALA-SFC in patients who undergo LDR-BT. To the best of our knowledge, this is the first study investigating the potential clinical benefit of oral ALA-SFC after radiotherapy. More evidence from a further randomized controlled trial is needed to change the standard of care and lead to better post-radiotherapy management. Trial registration: This clinical trial was prospectively registered with the Japan Registry of Clinical Trials on 5 December 2019. The reference number is jRCTs051190077, nara0013 (Certified Review Board of Nara Medical Univer...
Source: Clinical Prostate Cancer - July 10, 2020 Category: Cancer & Oncology Authors: Miyake M, Tanaka N, Asakawa I, Yamaki K, Inoue T, Suzuki S, Hori S, Nakai Y, Anai S, Torimoto K, Toritsuka M, Nakagawa H, Tsukamoto S, Fujii T, Ohbayashi C, Hasegawa M, Kasahara M, Fujimoto K Tags: Contemp Clin Trials Commun Source Type: research

Response to 'Unexpected lower biochemical control of high-dose-rate brachytherapy boost than low-dose-rate brachytherapy boost for clinically localized prostate cancer'.
PMID: 32637660 [PubMed] (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - July 10, 2020 Category: Cancer & Oncology Authors: Slevin F, Rodda SL, Bownes P, Murray L, Bottomley D, Melody C, Adiotomre E, Al-Qaisieh B, Dugdale E, Hulson O, Mason J, Smith J, Henry AM Tags: Clin Transl Radiat Oncol Source Type: research

Treatment of low-risk prostate cancer: a  retrospective study with 477 patients comparing external beam radiotherapy and I-125 seeds brachytherapy in terms of biochemical control and late side effects
ConclusionBoth EBRT and seeds provide excellent biochemical control with bNED rates after 10  years of about 90%. In terms of side effects, patients treated with seeds show higher grades of genitourinary side effects, while patients treated with EBRT show higher grades of gastrointestinal side effects. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 8, 2020 Category: Cancer & Oncology Source Type: research

Automatic multi-needle localization in ultrasound images using large margin mask RCNN for ultrasound-guided prostate brachytherapy.
Abstract Multi-needle localization in ultrasound (US) images is a crucial step of treatment planning for US-guided prostate brachytherapy. However, current computer-aided technologies are mostly focused on single-needle digitization, while manual digitization is labor intensive and time consuming. In this paper, we proposed a deep learning-based workflow for fast automatic multi-needle digitization, including needle shaft detection and needle tip detection. The major workflow is composed of two components: a large margin mask R-CNN model (LMMask R-CNN), which adopts the lager margin loss to reformulate Mask R-CNN ...
Source: Physics in Medicine and Biology - July 8, 2020 Category: Physics Authors: Zhang Y, Tian Z, Lei Y, Wang T, Patel P, Jani AB, Curran WJ, Liu T, Yang X Tags: Phys Med Biol Source Type: research

Adjuvant electronic brachytherapy for endometrial carcinoma: A 4-year outcomes report
The purpose of the study was to report the outcomes of a single-center adjuvant electronic brachytherapy (e-BT) experience for patients with endometrial carcinoma. (Source: Brachytherapy)
Source: Brachytherapy - July 7, 2020 Category: Cancer & Oncology Authors: Gustavo R. Sarria, Elena Sperk, Frederik Wenz, Frank Schneider, Yasser Abo-Madyan, Frank A. Giordano, Michael Ehmann Source Type: research

Salvage I-125 brachytherapy for locally-recurrent prostate cancer after radiotherapy
Publication date: Available online 5 July 2020Source: Reports of Practical Oncology & RadiotherapyAuthor(s): O. Pons-Llanas, J. Burgos-Burgos, S. Roldan-Ortega, A. Conde-Moreno, F. Celada-Alvarez, J.C. Ruiz, F. Lliso-Valverde, A. Tormo-Micó, J. Perez-Calatayud, J. López-Torrecilla (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - July 6, 2020 Category: Cancer & Oncology Source Type: research

Impact of intracavitary brachytherapy technique (2D versus 3D) on outcomes of cervical cancer: a  systematic review and meta-analysis
Conclusion3D-BT might reduce severe toxicity and improve LRRFS and PFS in patients with cervical cancer. 3D-BT should be considered for standard management of cervical cancer, and efforts for adopting this procedure in Korea should be pursued. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 6, 2020 Category: Cancer & Oncology Source Type: research

Clinical Application of Iodine-125 Seed Brachytherapy Combined with Anti-PD-1 Antibodies in the Treatment of Lung Cancer.
Abstract PURPOSE: The purpose of this case report was to investigate the clinical efficacy and tolerability of anti-programmed cell death protein (PD)-1 antibody combined with iodine (I)-125 seed brachytherapy in lung cancer treatment. METHODS: Three patients with advanced PD-L1-positive non-small-cell lung cancer were treated first with I-125 seed brachytherapy and then with anti-PD-1 antibody. Clinical efficacy was evaluated with Response Evaluation Criteria in Solid Tumors. FINDINGS: All 3 patients had complete response or partial response. None of the 3 patients had reported obvious adverse...
Source: Clinical Therapeutics - July 6, 2020 Category: Drugs & Pharmacology Authors: Sui A, Song H, Yu H, Zhang H, Hu Q, Lei Y, Zhang L, Wang J Tags: Clin Ther Source Type: research

Clinical Learning, Didactic Education, and Research Experiences of Radiation Oncology Resident Physicians in Canada
AbstractChanges in the field of radiation oncology (RO) impacts residency training. Assessing trainee experiences is essential to inform curriculum development. We aim to explore gaps and strengths in current Canadian RO training, as we move towards competency-based medical education (CBME). An online survey was distributed to residents at all Canadian RO training programs. Surveys consisted of 66 open-ended, Likert-scale, matrix-style, and multiple-choice questions, and assessed clinical exposure, didactic teaching, professional relationships, and research experiences. Statistics were calculated from anonymized, aggregate...
Source: Journal of Cancer Education - July 4, 2020 Category: Cancer & Oncology Source Type: research

Machine segmentation of pelvic anatomy in MRI-assisted radiosurgery (MARS) for prostate cancer brachytherapy
To investigate machine segmentation of pelvic anatomy in MRI-assisted radiosurgery (MARS) for prostate cancer using prostate brachytherapy MRIs acquired with different pulse sequences and image contrasts. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - July 4, 2020 Category: Radiology Authors: Jeremiah W. Sanders, Gary D. Lewis, Howard D. Thames, Rajat J. Kudchadker, Aradhana M. Venkatesan, Teresa L. Bruno, Jingfei Ma, Mark D. Pagel, Steven J. Frank Source Type: research

Hybrid TRUS/CT with optical tracking for target delineation in image-guided adaptive brachytherapy for cervical cancer
ConclusionHybrid TRUS-CT as an imaging modality for contouring the CTVHR in IGABT for LACC is feasible and reproducible among multiple observers. TRUS-CT substantially reduces overestimation of the CTVHR volume of CT alone while maintaining similar interobserver variability. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - July 3, 2020 Category: Cancer & Oncology Source Type: research

Overall survival comparison between androgen deprivation therapy (ADT) plus external beam radiation therapy (EBRT) vs ADT plus EBRT with brachytherapy boost in clinically node-positive prostate cancer
Optimal therapy for clinically node-positive, nonmetastatic (cN1) prostate cancer (PC) patients remains controversial, ranging from aggressive local therapy to palliative systematic therapy alone. Despite guideline support, it is unclear if a brachytherapy (BT) boost should be considered for cN1 patients as these patients were excluded from randomized trials establishing its benefit. Herein, we compare definitive radiation therapy (RT) with or without a BT boost in cN1 PC. (Source: Brachytherapy)
Source: Brachytherapy - July 3, 2020 Category: Cancer & Oncology Authors: Benjamin W. Fischer-Valuck, Yuan James Rao, Randall J. Brenneman, Pretesh R. Patel, Christopher P. Filson, Ashesh B. Jani, Yuan Liu, Subir Goyal, Karen Xu, Aaron Weiss, Omer Kucuk, Cara Cimmino, Stephen Szabo, Peter Rossi, Brian C. Baumann, John Pattaras, Source Type: research

A semiautomatic segmentation method for interstitial needles in intraoperative 3D transvaginal ultrasound images for high-dose-rate gynecologic brachytherapy of vaginal tumors
The purpose of this study was to evaluate the use of a semiautomatic algorithm to simultaneously segment multiple high-dose-rate (HDR) gynecologic interstitial brachytherapy (ISBT) needles in three-dimensional (3D) transvaginal ultrasound (TVUS) images, with the aim of providing a clinically useful tool for intraoperative implant assessment. (Source: Brachytherapy)
Source: Brachytherapy - July 3, 2020 Category: Cancer & Oncology Authors: Jessica Robin Rodgers, William Thomas Hrinivich, Kathleen Surry, Vikram Velker, David D'Souza, Aaron Fenster Source Type: research

Techniques for and uncertainties of MRI-based reconstruction of titanium tandem and ring brachytherapy applicators
Eliminating patient computed tomography (CT) scans for tandem and ring (T&R) brachytherapy can reduce overall procedure time and eliminates imaging dose. However, reconstructing titanium applicators in magnetic resonance imaging (MRI) is challenging. We evaluated the uncertainty of different applicator reconstruction workflows in MR-guided brachytherapy, and assessed the clinical impact of reconstruction uncertainties. (Source: Brachytherapy)
Source: Brachytherapy - July 3, 2020 Category: Cancer & Oncology Authors: Irina Malajovich, Shibu Anamalayil, Otilia Valentina Dolney, Boon-Keng Kevin Teo, William Tristram Arscott, Neil K. Taunk Source Type: research

Tolerability, Efficacy and Feasibility of Concurrent Gemcitabine and Cisplatin (CGP) Combined With Intensity Modulated Radiotherapy for Loco-Regionally Advanced Carcinoma of the Cervix
Conclusions: Unlike past results, gemcitabine and cisplatin appear to be tolerable, efficient and feasible when combined with conformal radiotherapy. (Source: Journal of Cancer)
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Emmanuel Kwateng Drokow, Liu Zi, Han Qian, Lanlan Xu, Francis Foli, Hafiz Abdul Waqas Ahmed, Gloria Selorm Akpabla, Guangyin Wu, Emmanuel Bamfo Agyekum, Weihua Gao, Marie-Anne Deku, Juanjuan Song, Kai Sun Tags: Research Paper Source Type: research

Unexpected lower biochemical control of high-dose-rate brachytherapy boost than low-dose-rate brachytherapy boost for clinically localized prostate cancer.
PMID: 32596516 [PubMed] (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yamazaki H, Masui K, Suzuki G, Yoshida K Tags: Clin Transl Radiat Oncol Source Type: research

Cancers, Vol. 12, Pages 1770: FIGO 2018 Staging for Cervical Cancer: Influence on Stage Distribution and Outcomes in the 3D-Image-Guided Brachytherapy Era
Tatsuya Ohno Recent widespread use of three-dimensional image-guided brachytherapy (3D-IGBT) has improved radiotherapy outcomes of cervical cancer dramatically. In 2018, the International Federation of Gynecology and Obstetrics (FIGO) staging system for cervical cancer was revised. However, the influence of the revisions on the stage distribution and outcomes of cervical cancers treated with 3D-IGBT remains unclear. Here, we retrospectively analyzed 221 patients with cervical squamous cell carcinoma treated with definitive radiotherapy using 3D-IGBT (median follow-up, 60 months). The stage distribution and outcomes ...
Source: Cancers - July 2, 2020 Category: Cancer & Oncology Authors: Kento Tomizawa Takuya Kaminuma Kazutoshi Murata Shin-ei Noda Daisuke Irie Takuya Kumazawa Takahiro Oike Tatsuya Ohno Tags: Article Source Type: research

A kinetic model of continuous radiation damage to populations of cells: comparison to the LQ model and application to molecular radiotherapy.
Abstract The linear-quadratic (LQ) model to describe the survival of irradiated cells may be the most frequently used biomathematical model in radiotherapy. There has been an intense debate on the mechanistic origin of the LQ model. An interesting approach is that of obtaining LQ-like behavior from kinetic models, systems of differential equations that model the induction and repair of damage. Development of such kinetic models is particularly interesting for application to continuous dose rate therapies, such as molecular radiotherapy or brachytherapy. In this work, we present a simple kinetic model that describe...
Source: Physics in Medicine and Biology - July 2, 2020 Category: Physics Authors: Neira S, Gago-Arias MA, Guiu-Souto J, Pardo-Montero J Tags: Phys Med Biol Source Type: research

Toxicity and dosimetry in SORAMIC study
Ricke et  al. reported their findings on the efficacy and safety of selective internal radiation therapy (SIRT) with resin yttrium-90 (90Y) microspheres (SIR-Spheres®, Sirtex) in combination with sorafenib compared to sorafenib treatment alone. This clinical trial with a superiority design, also known as t he SORAMIC study, was performed in patients with intermediate to advanced hepatocellular carcinoma (HCC). No overall survival (OS) benefit was found when adding SIRT to sorafenib treatment. In the ‘intention-to-treat’ population, median OS was 12.1 months in the SIRT plus sorafenib group vs. (Source:...
Source: Journal of Hepatology - July 1, 2020 Category: Gastroenterology Authors: Margot Reinders, Arthur Braat, Marnix Lam Tags: Letter to the Editor Source Type: research

Multi-Needle Detection in 3D Ultrasound Images Using Unsupervised Order-Graph Regularized Sparse Dictionary Learning
Accurate and automatic multi-needle detection in three-dimensional (3D) ultrasound (US) is a key step of treatment planning for US-guided brachytherapy. However, most current studies are concentrated on single-needle detection by only using a small number of images with a needle, regardless of the massive database of US images without needles. In this paper, we propose a workflow for multi-needle detection by considering the images without needles as auxiliary. Concretely, we train position-specific dictionaries on 3D overlapping patches of auxiliary images, where we develop an enhanced sparse dictionary learning method by...
Source: IEE Transactions on Medical Imaging - July 1, 2020 Category: Biomedical Engineering Source Type: research

Does ADT benefit unfavourable intermediate risk prostate cancer patients treated with brachytherapy boost and external beam radiotherapy? A propensity-score matched analysis
The addition of androgen deprivation therapy (ADT) to radiotherapy (RT) is the standard of care for prostate cancer patients with unfavourable intermediate risk (UIR) and high-risk disease. In this population, ADT has been shown to improve oncological outcomes by increasing RT local effect [1 –3] and likely by reducing the micrometastatic burden. Although the role of ADT in high-risk prostate cancer patients is firmly established, the benefit associated with this therapy in UIR patients treated with dose-escalated RT is less well defined [4,5]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - June 30, 2020 Category: Radiology Authors: Lucas C. Mendez, Kevin Martell, Andrew Warner, Chia-Lin Tseng, Hans Chung, Andrew Loblaw, George B. Rodrigues, Gerard Morton Source Type: research

Does ADT benefit unfavourable intermediate risk prostate cancer patients treated with brachytherapy boost and external beam radiotherapy? A propensity-score matched analysis.
CONCLUSION: Short-term ADT increased BFFS in UIR prostate cancer patients treated with HDR-BT boost plus EBRT. PMID: 32619455 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 30, 2020 Category: Radiology Authors: Mendez LC, Martell K, Warner A, Tseng CL, Chung H, Loblaw A, Rodrigues GB, Morton G Tags: Radiother Oncol Source Type: research

Augmenting the therapeutic window of radiotherapy: A perspective on molecularly targeted therapies and nanomaterials
Radiation therapy remains an essential component of cancer therapy for millions of patients annually in the United States and globally. Radiation therapy involves the focal deposition of ionizing radiation (IR) to the tumor and surrounding at-risk tissue compartments such as regional lymph nodes. The most common treatment approaches include external beam radiation therapy (EBRT) using high-energy photons, electrons, or protons, as well as brachytherapy and radionuclide therapy. Significant technical advances in EBRT and diagnostic imaging over the past several decades have enabled more localized and precise dose deposition...
Source: Radiotherapy and Oncology - June 26, 2020 Category: Radiology Authors: Moataz Reda, Alexander F. Bagley, Husam Y. Zaidan, Wassana Yantasee Tags: Review Article Source Type: research

Long-term results of a protocol-based ultrasound-guided salvage brachytherapy as re-irradiation for local recurrent prostate cancer
Alongside radical prostatectomy, radiation therapy is an effective treatment modality for prostate cancer patients irrespective of risk group. Nevertheless, a considerable number of these patients are faced with isolated local failure of prostate cancer after radiation therapy with curative intent. Up to 10% of patients with a low-risk, 10-20% with an intermediate-risk and up to 30-37% with high-risk tumors will suffer local recurrence during follow-up [1 –4]. Thus, the possibility of an effective local salvage therapy is of paramount importance for curative therapy of a prostate cancer recurrence. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - June 25, 2020 Category: Radiology Authors: Nicole Sch önle, Vratislav Strnad, Michael Lotter, Stephan Kreppner, Rainer Fietkau Tags: Original Article Source Type: research

Prostate SBRT: Comparison the Efficacy and Toxicity of Two Different Dose Fractionation Schedules
Background: CyberKnife SBRT is capable of producing dosimetry comparable to that created by HDR brachytherapy. Our original CyberKnife prostate SBRT schedule of 3,800 cGy/4 fractions (“high dose”) was based upon favorable published prostate HDR brachytherapy experience. Subsequently, our trial was modified to allow a lower dose of 3,400 cGy/5 fractions (“moderate dose”) in selected cases.Methods: Two hundred eighty-nine low and intermediate-risk patients were treated to either high dose (178 pts) or moderate dose (111 pts). The dose selection was individualized; high dose more commonly used in young...
Source: Frontiers in Oncology - June 25, 2020 Category: Cancer & Oncology Source Type: research

OCT changes in peri-tumour normal retina following ruthenium-106 and proton beam radiotherapy for uveal melanoma.
Abstract INTRODUCTION: Uveal melanoma is most commonly treated with radiotherapy, destroying the tumour cells with adequate safety margins and limiting collateral damage to surrounding structures to preserve maximal vision. We used optical coherence tomography (OCT) to study the effects of radiotherapy on the retina. METHODS: Patients with posteriorly located choroidal melanoma treated with proton beam radiotherapy (PBR) and ruthenium-106 brachytherapy between January 2010 and June 2014 underwent spectral domain OCT. RESULTS: Images of 32 patients following ruthenium-106 brachytherapy and 44 patients fol...
Source: The British Journal of Ophthalmology - June 25, 2020 Category: Opthalmology Authors: Hussain R, Heussen FM, Heimann H Tags: Br J Ophthalmol Source Type: research

Long-term results of a protocol-based ultrasound-guided salvage brachytherapy as re-irradiation for local recurrent prostate cancer.
CONCLUSION: PDR salvage brachytherapy in local recurrent previously irradiated prostate cancer is efficient with low late toxicity. Salvage-brachytherapy represents a valuable therapeutic option for the treatment of previously irradiated locally recurrent prostate cancer. PMID: 32593646 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 25, 2020 Category: Radiology Authors: Schönle N, Strnad V, Lotter M, Kreppner S, Fietkau R Tags: Radiother Oncol Source Type: research

Permanent iodine-125 brachytherapy for patients with progressive or recurrent high-grade gliomas
This study a... (Source: BMC Cancer)
Source: BMC Cancer - June 24, 2020 Category: Cancer & Oncology Authors: Congxiao Wang, Shifeng Liu, Lijing Peng, Kaixian Zhang, Wei Li, Hao Zhang, Ying Luan, Peishun Li and Xiaokun Hu Tags: Research article Source Type: research

Brachytherapy education and certification —A Canadian approach
The Royal College of Physicians and Surgeons of Canada has established a diploma certification program in brachytherapy, with the goal of standardizing brachytherapy training and standards. The diploma may be obtained either by way of a training route or a Practice Eligibility Route. Training is undergone through a Royal College –accredited brachytherapy program, analogous to a residency program with clearly defined curriculum, objectives, and expectations. The trainee submits a portfolio demonstrating achievement of the various competencies required and typically takes 12 months to complete. (Source: Brachytherapy)
Source: Brachytherapy - June 24, 2020 Category: Cancer & Oncology Authors: Gerard Morton, Aman Taggar, Mira Keyes, Juanita Crook Source Type: research

COVID-19: hypofractionation in the Radiation Oncology Department during the 'state of alarm': first 100 patients in a private hospital in Spain.
We report the results of the first 100 patients who have experienced radiotherapy treatment since the state of alarm (66 women and 34 men). In these patients, the FI is 12.12-lower than previous years. PMID: 32565905 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - June 23, 2020 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

IJERPH, Vol. 17, Pages 4510: Differences in Treatment Outcomes and Prognosis between Elderly and Younger Patients Receiving Definitive Radiotherapy for Cervical Cancer
Shueng The aim was to compare the clinical outcomes and prognostic factors of cervical cancer between elderly and younger women, and to explore which treatment strategy is more appropriate for elderly patients. We retrospectively reviewed patients with cervical cancer receiving definitive radiotherapy (RT) between 2007 and 2016, and divided them into two age groups: age < 70 vs. age ≥ 70. The clinical outcomes were compared between the two age groups. The median follow-up was 32.2 months. A total of 123 patients were eligible, 83 patients in group 1 (age < 70), and 40 patients in gr...
Source: International Journal of Environmental Research and Public Health - June 23, 2020 Category: Environmental Health Authors: Hou Hsieh Wei Hsiao Shueng Tags: Article Source Type: research

IDENTIFICATION AND CLASSIFICATION OF MACULAR MORPHOLOGIC BIOMARKERS RELATED TO VISUAL ACUITY IN RADIATION MACULOPATHY: A Multimodal Imaging Study
Conclusion: The vertical thickness of the thickest macular cyst, the presence of foveal retinal pigment epithelium atrophy, and IS/OS layer disruption can be used to clinically characterize radiation maculopathy. These parameters allow for separation of the edematous component of radiation maculopathy, which is potentially treatable in early disease stages, from late onset atrophic components, which are theoretically irreversible. (Source: RETINA)
Source: RETINA - June 20, 2020 Category: Opthalmology Tags: Original Study Source Type: research

Combination of computed tomography-guided iodine-125 brachytherapy and bronchial arterial chemoembolization for locally advanced stage III non-small cell lung cancer after failure of concurrent chemoradiotherapy11Abbreviations: BAI, bronchial arterial infusion; BACE, bronchial arterial chemoembolization; CR, complete response; CT, computed tomography; D90, dose covering 90% of the target volume; NSCLC, non-small cell lung cancer; OS, overall survival; PR, partial response; PFS, progression-free survival; PD, progressive disease; SD, stable disease; TPS, treatment planning system
Lung cancer is the leading cause of cancer-related death worldwide. Owing to the lack of modalities for early diagnosis, 75 % of lung cancer patients are diagnosed at the advanced stage of the disease and, thus, cannot undergo resection [1]. Non-small cell lung cancer (NSCLC) accounts for 80 –85 % of all cases of lung cancer. The first-line standard treatment for advanced inoperable NSCLC is combined chemoradiotherapy [2]. However, treatment failure is noted in some patients, and those who undergo chemoradiotherapy as second-line therapy still have short overall survival (OS) and poor prognosis [3]. (Source: Lung Cancer)
Source: Lung Cancer - June 20, 2020 Category: Cancer & Oncology Authors: Chao Chen, Wei Wang, Zhe Yu, Shilin Tian, Yuliang Li, Yongzheng Wang Source Type: research

Toxicity and cosmetic outcomes after treatment with a novel form of breast IORT
Intraoperative radiation therapy (IORT), a form of accelerated partial breast irradiation (APBI), is an appealing alternative to postoperative whole breast irradiation for early-stage breast cancer. The purpose of this study was to examine the toxicity and cosmetic outcomes of patients treated with a novel form of breast IORT (precision breast IORT; PB-IORT), that delivers a targeted, higher dose of radiation than conventional IORT. (Source: Brachytherapy)
Source: Brachytherapy - June 20, 2020 Category: Cancer & Oncology Authors: Max O. Meneveau, Gina R. Petroni, Nikole E. Varhegyi, John C. Hulse, Anneke T. Schroen, David R. Brenin, Einsley M. Janowski, Adam C. Berger, Melissa A. Lazar, Nicole L. Simone, Timothy N. Showalter, Shayna L. Showalter Source Type: research

[Brachytherapy in France in 2020: State of the art and perspectives from the Groupe curieth érapie de la SFRO].
[Brachytherapy in France in 2020: State of the art and perspectives from the Groupe curiethérapie de la SFRO]. Cancer Radiother. 2020 Jun 20;: Authors: Hannoun-Lévi JM, Chand MÈ, Blanchard P, Chargari C, Escande A, Pierrat N, Pommier P, Peiffert D Abstract Because of its principle and its high proof level clinical results, brachytherapy represents a specific irradiation technique for the treatment of primary tumors as well as some local relapses in pre-irradiated area. After a glory period between the 80's and 90's, brachytherapy has progressively lost its attractiveness. In order...
Source: Cancer Radiotherapie - June 20, 2020 Category: Cancer & Oncology Authors: Hannoun-Lévi JM, Chand MÈ, Blanchard P, Chargari C, Escande A, Pierrat N, Pommier P, Peiffert D Tags: Cancer Radiother Source Type: research

Usefulness of 18F-Choline Positron Emission Tomography - Computed Tomography in the therapeutic management of patients with biochemical recurrence of prostate adenocarcinoma treated with brachytherapy.
CONCLUSION: 18F-choline PET/CT could be a useful technique in the group of patients with biochemical recurrence after brachytherapy, providing locoregional and distant involvement findings which had not been detected with conventional imaging tests, thus determining a more adequate therapeutic management. PMID: 32576406 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - June 20, 2020 Category: Urology & Nephrology Authors: López Rodríguez E, Tirado Hospital JL, Álvarez Pérez RM, Gómez Izquierdo L, Jiménez-Hoyuela JM Tags: Actas Urol Esp Source Type: research

Optimized stereotactic volumetric modulated arc therapy as an alternative to brachytherapy for vaginal cuff boost. A dosimetric study
We evaluate the role of stereotactic body radiotherapy using volumetric modulated arc therapy (VMAT) technique as an alternative to high-dose rate brachytherapy (HDR-BT) in the treatment of vaginal cuff in postoperative endometrial cancer. CT scans of 8 patients were used in this study. The clinical target volume (CTV) was defined as the 0.5 cm tissue around the applicator (then subtracting the applicator). Total dose was 30Gy delivered in 5 fractions. In HDR-BT, dose was prescribed at a distance of 0.5 cm from the surface applicator. (Source: Medical Dosimetry)
Source: Medical Dosimetry - June 19, 2020 Category: Radiology Authors: Savino Cilla, Gabriella Macchia, Giancarlo Mattiucci, Anna Ianiro, Carmela Romano, Milly Buwenge, Luigi Azario, Vincenzo Valentini, Francesco Deodato, Alessio G. Morganti Source Type: research

Successful treatment of ciliary body medulloepithelioma with intraocular melphalan chemotherapy: a case report
We report for the first ... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - June 18, 2020 Category: Opthalmology Authors: Christina Stathopoulos, Marie-Claire Gaillard, Julie Schneider and Francis L. Munier Tags: Case report Source Type: research

Iodine-125 Brachytherapy Can Prolong Progression-Free Survival of Patients with Locoregional Recurrence and/or Residual Hepatocellular Carcinoma After Radiofrequency Ablation
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Source: Cancer Biotherapy and Radiopharmaceuticals - June 16, 2020 Category: Cancer & Oncology Authors: Li Chen Xihui Ying Dengke Zhang Linqiang Lai Fazong Wu Jianfei Tu Jiansong Ji Source Type: research

Synchronous Well-differentiated Endometrioid Adenocarcinoma and Leiomyosarcoma of the Uterus With Pulmonary Metastasis in a 50-Yr-Old Woman: A Case Report and Review of Literature
We report the case of a 50-yr-old woman who was diagnosed with concomitant endometrial adenocarcinoma and uterine leiomyosarcoma. The sarcomatous neoplasm was positive for anti-smooth muscle actin and CD10, and focally positive for Cytokeratin AE1/AE3 and Cytokeratin Cam 5.2. She underwent total abdominal hysterectomy with bilateral salpingoopherectomy followed by radiation, brachytherapy, and chemotherapy. Three years later, she presented with cough and dyspnea and was found to have pulmonary metastasis. These tumor cells were positive for anti-smooth muscle actin, Cytokeratin AE1/AE3, Cytokeratin Cam 5.2, and epithelial ...
Source: International Journal of Gynecological Pathology - June 13, 2020 Category: Pathology Tags: PATHOLOGY OF THE CORPUS: CASE REPORTS Source Type: research

Cancers, Vol. 12, Pages 1557: Personalised Dosimetry in Radioembolisation for HCC: Impact on Clinical Outcome and on Trial Design
lland Selective internal radiation therapy (SIRT) of hepatocellular carcinoma (HCC) has been used for many years, usually without any specific dosimetry endpoint. Despite good clinical results in early phase studies or in cohort studies, three randomized trials in locally advanced HCC available failed to demonstrate any improvement of overall overall survival (OS) in comparison with sorafenib. In recent years, many studies have evaluated the dosimetry of SIRT using either a simulation-based dosimetry (macroaggregated albumin (MAA)-based) or a post-therapy-based one (90Y-based). The goal of this review is to present the...
Source: Cancers - June 12, 2020 Category: Cancer & Oncology Authors: Etienne Garin Xavier Palard Yan Rolland Tags: Review Source Type: research

Development of an indigenous low-cost multichannel cylinder applicator for vaginal tumors
The purpose of this study was to report our experience regarding the development of a low-cost multichannel vaginal cylinder applicator for superficial and recurrent vaginal tumors. (Source: Brachytherapy)
Source: Brachytherapy - June 12, 2020 Category: Cancer & Oncology Authors: Harjot Kaur Bajwa, Rohith Singareddy, Anil Kumar Talluri, Rajeev Guntupalli, Alluri Krishnam Raju, Madhusudhana Sresty, Ameer Ahmed Tags: Case Report Source Type: research

External Validation of a Predictive Model of Urethral Strictures for Prostate Patients Treated With HDR Brachytherapy Boost
Conclusions: Lyman–Kutcher–Burman model parameters were fitted to the risk of urethral stricture and externally validated with an independent cohort, to provide guidance on urethral tolerance doses for patients treated with a HDRB boost. For patients that did not receive AD, model fitting provided a lower TD50 suggesting a protective effect on urethra toxicity. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - June 11, 2020 Category: Cancer & Oncology Source Type: research

Safety and Effectiveness Analysis of Percutaneous Microwave Thermal Ablation Therapy Combined Brachytherapy for Lung Malignant Lesion
Conclusion Seed implantation combined with CT-guided microwave ablation for advanced lung cancer and lung metastases is safety and effective. DOI: 10.3779/j.issn.1009-3419.2020.102.06 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Intensity modulated Ir-192 brachytherapy using high-Z 3D printed applicators.
Abstract Gynecologic cancers are often asymmetric, yet current Ir-192 brachytherapy techniques provide only limited radial modulation of the dose. The shielded solutions investigated here solve this by providing the ability to modulate between highly asymmetric and radially symmetric dose distributions at a given location. To find applicator designs that can modulate between full dose and less than 50% dose, at the dimensions of the urethra, a 2D calculation algorithm was developed to narrow down the search space. Two shielding design types were then further investigated using Monte Carlo and Boltzmann-solver dose...
Source: Physics in Medicine and Biology - June 10, 2020 Category: Physics Authors: Skinner LB, Niedermayr T, Prionas N, Perl J, Fahimian BP, Kidd E Tags: Phys Med Biol Source Type: research

The clinical efficacy of PSMA PET/MRI in biochemically recurrent prostate cancer compared with standard of care imaging modalities and confirmatory histopathology: results of a single-centre, prospective clinical trial
AbstractProspective evidence for the clinical role and efficacy of prostate specific membrane antigen (PSMA) positron emission tomography (PET)/magnetic resonance imaging (MRI) combining MRI characterization and localization of lesions with PET avidity in comparison to conventional imaging is limited. In a prospective clinical trial, we aimed to evaluate the diagnostic yield and therapeutic impact of PSMA PET/MRI in men with biochemical recurrence (BCR) following curative therapy. A single-centre, prospective clinical trial at the Princess Alexandra Hospital recruited 30 patients with BCR. Patients underwent PSMA PET/MRI a...
Source: Clinical and Experimental Metastasis - June 9, 2020 Category: Cancer & Oncology Source Type: research

Diagnostic performance of imaging techniques for detecting of local recurrence after prostate brachytherapy.
CONCLUSION: Both MRI and fluorocholine PET/CT permit to highlight local recurrence sites after prostate brachytherapy. Confirmation biopsies are, however, necessary since this accuracy is insufficient. PMID: 32532578 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - June 9, 2020 Category: Cancer & Oncology Authors: Karahissarlian V, Sargos P, Blais E, Cazeau AL, Fontes F, Petitpierre F, Rigou G, De Vaugelade C, Mariey A, Hindié E, Thomas L Tags: Cancer Radiother Source Type: research