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Evidence for Cellular Senescence to Contribute to Osteoporosis
We report that the number of TdRFP-Osx1 cells, freshly isolated from the bone marrow, declines by more than 50% between 6 and 24 months of age in both female and male mice. Moreover, TdRFP-Osx1 cells from old mice exhibited markers of DNA damage and senescence. Bone marrow stromal cells from old mice also exhibited elevated expression of SASP genes, including several pro-osteoclastogenic cytokines, and increased capacity to support osteoclast formation. These changes were greatly attenuated by the senolytic drug ABT263. Together, these findings suggest that the decline in bone mass with age is the result of intrinsic defec...
Source: Fight Aging! - April 15, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Why do patients accept chemotherapy, but not flu shots?
Fall brings school buses, a freshening breeze and an avalanche of meetings.  There are seasonal sales, myriad projects and the splendor of colored leaves.  The season is also announced, again and again, by a particular peculiar and perilous decision, which, no matter how much I try, I do not fully understand. Frankly, I just don’t get it. “Jane, it is time to start chemotherapy.” “What are the side effects?” “Well, this is powerful chemotherapy.  It is necessary to cure your cancer.  It will cause hair loss. It will cause a drop in your blood counts.  It might cause severe diarrhea.  There might be numbne...
Source: Kevin, M.D. - Medical Weblog - November 1, 2016 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/james-c-salwitz" rel="tag" > James C. Salwitz, MD < /a > Tags: Physician Medications Source Type: blogs

Fight Aging! Newsletter, August 1st 2016
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - July 31, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, May 23rd 2016
FIGHT AGING! NEWSLETTER May 23rd 2016 Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to o...
Source: Fight Aging! - May 22, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The story of an exhausted doctor daughter
I am a doctor daughter. I am exhausted. My emotions are bubbling close to the surface, and I fear that at any moment, someone will do or say something to me that will cause me to lose control, which I’m not allowed to do because I’m also a female physician in a leadership role, and our emotions must be held in check. I watched one of my mentors be memorialized last week after he lost his battle with cancer. This week, I will watch my father, a man who has meant more to me in my life than any other except my husband, go through a revision prostate surgery, a bone marrow biopsy, and an inpatient stay for a urinary tract ...
Source: Kevin, M.D. - Medical Weblog - May 12, 2016 Category: Journals (General) Authors: Tags: Physician Cancer Pediatrics Source Type: blogs

Fight Aging! Newsletter, May 2nd 2016
This study is the first CAR T-cell trial to infuse patients with an even mixture of two types of T cells (helper and killer cells, which work together to kill cancer). With the assurance that each patient gets the same mixture of cells, the researchers were able to come to conclusions about the effects of administering different doses of cells. In 27 of 29 participants whose responses were evaluated a few weeks after the infusion, a high-sensitivity test could detect no trace of their cancer in their bone marrow. The CAR T cells eliminated cancers anywhere in the body they appeared. Of the two participants who did n...
Source: Fight Aging! - May 1, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

MKSAP: 68-year-old man with dyspnea on exertion
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 68-year-old man is evaluated for a 3-year history of dyspnea on exertion. He experiences no headaches or blurred vision. Medical history is notable for a stroke 2 years ago. He is a smoker with an 80-pack-year smoking history. Medications are hydrochlorothiazide, lisinopril, aspirin, and simvastatin. On physical examination temperature is 36.7 °C (98.0 °F), blood pressure is 145/84 mm Hg, pulse rate is 88/min, and respiration rate is 16/min. Oxygen saturation breathing ambient air is 88%. He has facial pleth...
Source: Kevin, M.D. - Medical Weblog - January 23, 2016 Category: Journals (General) Authors: Tags: Conditions Pulmonology Source Type: blogs

Scary or Encouraging?
My myeloma is the Immunoglobulin G (IgG) type, so the doctors and I consider that the blood proteins IgG and M-spike (monoclonal protein) are the best markers for my tumor burden.  Last Tuesday IgG jumped 21% from 1390 to 1680 mg/dL, the highest value in years and the largest jump I have ever seen between two measurements.  That jump happened in just one week. Either the myeloma has suddenly gone crazy, or something else is going on.  This blog is titled Myeloma Hope, so I hope that something else is happening, something good. My doctor ML warned me in advance that the myeloma markers might not even be me...
Source: Myeloma Hope - January 18, 2016 Category: Cancer & Oncology Source Type: blogs

Bone Marrow Biopsy
PET/CT scan, PET/MRI scan, 46 vials of blood, two 24-hour urine collections, two more urine samples, ECG, Skeletal (x-ray) bone survey.  That is the list of tests required for qualification and for Cycle 1 Day 1 of my new myeloma therapy trial.  Not to mention height, weight, blood pressure, temperature, walking blood oxygen, and a short physical exam. I won't name the medications involved in the trial yet because, in case they don't work for me, I wouldn't want to discourage anyone else from using them.  One of them is already a whiz-bang success for certain other cancers.  I can say that the study do...
Source: Myeloma Hope - December 11, 2015 Category: Cancer & Oncology Source Type: blogs

Test your medicine knowledge: 48-year-old woman with fatigue
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 48-year-old woman is evaluated for fatigue and intermittent abdominal discomfort of 2 months’ duration and occasional dark urine. Medical and family histories are unremarkable. Her only medication is an oral contraceptive pill. On physical examination, temperature is 37.2 °C (99.0 °F), blood pressure is 125/74 mm Hg, pulse rate is 68/min, and respiration rate is 13/min. Pallor is observed, and abdominal tenderness is present on palpation. No icterus, bruising, or splenomegaly is noted. Laboratory studi...
Source: Kevin, M.D. - Medical Weblog - October 17, 2015 Category: Journals (General) Authors: Tags: Conditions Hematology Source Type: blogs

Why I am a Crusader in the Anti-Vaccine, Anti-Drug Movement
Conclusion The doctors gave my daughter drugs they knew would cause her kidneys to stop working. They gave her these drugs in spite of both of us telling them on a day-to-day basis not to give them. The hospital covered it up. The hospital refused to give us the incident report. The hospital refused to give us a copy of the notes from the meeting with the ethics committee. The hospital denied my daughter’s right to make her own decisions. The hospital tried to deny me from being my daughter's advocate. The hospital administrator threatened to charge me with practicing medicine without a license. The CEO refused to talk t...
Source: vactruth.com - September 11, 2015 Category: Allergy & Immunology Authors: Jim O'Kelly Tags: Case Reports on Vaccine Injury Human Jim O'Kelly Top Stories truth about vaccines Vaccine Death Source Type: blogs

Discussing the Path to a Tissue Engineered Liver
An interesting interview with a tissue engineer can be found at the Methuselah Foundation blog. It covers one view of the path from today's research to the clinical availability of complete engineered livers constructed to order, among other subjects: [The most significant challenge] definitely has to do with scaling up our cell sources, because the liver is such a large organ, and you just need an enormous volume of cells. We can take fat-derived bone marrow stem cells and turn them into pretty much any cell that we want, but we need such large quantities that we may have to combine cells from different populations in or...
Source: Fight Aging! - October 13, 2014 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Stay Off the Admit Train
A man in his mid-50s with intermittent nosebleeds was sent in by his primary doctor for “abnormal labs.” The CBC sent from the office revealed a hemoglobin of 5.9 mg/dL. He had no past medical history and no sites of bleeding except for nosebleeds. Labs were sent to confirm the anemia as well as for potential admission.   His lab results were WBC 5.5; HGB 5.0; platelets 160; NA 124; K 3.4; Cl 99; CO2 23; BUN 16; Cr 1.8; glucose 71; anion gap 2; calcium 9.3; and albumin 2.1.   What is his diagnosis?   With the pressure on wait times and length of stay, I think much more often we put patients on the "admit train&...
Source: Lions and Tigers and Bears - August 20, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs

Stay Off the Admit Train
A man in his mid-50s with intermittent nosebleeds was sent in by his primary doctor for “abnormal labs.” The CBC sent from the office revealed a hemoglobin of 5.9 mg/dL. He had no past medical history and no sites of bleeding except for nosebleeds. Labs were sent to confirm the anemia as well as for potential admission.   His lab results were WBC 5.5; HGB 5.0; platelets 160; NA 124; K 3.4; Cl 99; CO2 23; BUN 16; Cr 1.8; glucose 71; anion gap 2; calcium 9.3; and albumin 2.1.   What is his diagnosis?   With the pressure on wait times and length of stay, I think much more often we put patients on the "admit ...
Source: Lions and Tigers and Bears - August 20, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs