Bone Marrow Aspiration and Biopsy Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Triclonal Gammopathy in Multiple Myeloma with Bleeding Diathesis: A Case Report
ConclusionIn plasma cell dyscrasias and lymphoproliferative diseases, monoclonal gammopathies are often observed, while the biclonal variety is less frequent. However, tri clonal gammopathy having a combination of IgM Kappa, IgG Kappa, and IgA Lambda is extremely rare and their clinical significance is unknown. (Source: Indian Journal of Clinical Biochemistry)
Source: Indian Journal of Clinical Biochemistry - April 22, 2024 Category: Biochemistry Source Type: research

p53 immunohistochemistry as an ancillary tool for rapid assessment of residual disease in TP53-mutated acute myeloid leukemia and myelodysplastic syndromes
CONCLUSIONS: Our study suggests that p53 IHC can be used as a rapid tool (within 24 hours) to aid in the detection of residual disease that may complement MRD-FC or NGS in cases in which the flow cytometry immunophenotype is equivocal and/or the bone marrow aspirate is suboptimal.PMID:38643353 | DOI:10.1093/ajcp/aqae034 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - April 21, 2024 Category: Pathology Authors: Nivaz Brar Lauren Lawrence Eula Fung James L Zehnder Peter L Greenberg Gabriel N Mannis Tian Y Zhang Dita Gratzinger Jean Oak Oscar Silva Jason Kurzer Brent Tan Joshua R Menke Sebastian Fernandez-Pol Source Type: research

A case report and literature review of IgA nephropathy presenting as nephrotic syndrome in polycythemia vera
AbstractA 66-year-old non-smoker presented with a 2-week history of new-onset pedal oedema and gross haematuria. On evaluation, he was found to be hypertensive and oedematous with a haemoglobin of 19.1 g/dl, platelet count of 546,000/mm3, and creatinine of 2.6 mg/dl. Urine examination revealed abundant RBCs with 3+ albumin on three separate occasions. His 24-h urine protein level was 3830 mg/day, with a serum cholesterol level of 303 mg/dl. Secondary erythrocytosis and thrombocytosis tests were negative. Bone marrow examination revealed hypercellulari ty, erythroid hyperplasia, tight clusters of large megakaryocytes,...
Source: CEN Case Reports - April 21, 2024 Category: Urology & Nephrology Source Type: research

Diagnosis of bone marrow involvement in angioimmunoblastic T-cell lymphoma should be based on both [ < sup > 18 < /sup > F]FDG-PET/CT and bone marrow biopsy findings
CONCLUSION: In AITL patients, PET/BM-positive results may obviate the necessity for repeat BMB to ascertain confirm BM involvement. PET/BM-negative results do not definitively exclude BM involvement. The combined use of [18F]FDG-PET/CT and BMB can increase the diagnostic accuracy of BM involvement for AITL patients.PMID:38626218 | DOI:10.1080/03007995.2024.2337670 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 16, 2024 Category: Research Authors: Xinyu Liang Chunli Yang Minggang Su Liqun Zou Source Type: research

Predictive value of 18 F-FDG PET/CT versus bone marrow biopsy and aspiration in pediatric neuroblastoma
Conclusion18 F-FDG-PET/CT is a valuable method for evaluating BMM in NB. The routine practice of performing a BMBA without discrimination may need to be reassessed. Negative result from 18 F-FDG-PET/CT could potentially spare children with invasive bone marrow biopsies. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - April 13, 2024 Category: Cancer & Oncology Source Type: research

Clinical characterization of hemophagocytic lymphohistiocytosis caused by immune checkpoint inhibitors: a review of published cases
CONCLUSION: HLH should be not underestimated as a potentially serious adverse effect of immune checkpoint inhibitors since appropriate treatments may save the life of patients.PMID:38606818 | DOI:10.1080/16078454.2024.2340144 (Source: Hematology)
Source: Hematology - April 12, 2024 Category: Hematology Authors: Zhiya Xu Huilan Li Xinyi Yu Jia Luo Zanling Zhang Source Type: research

Bilateral adrenal neuroblastoma: peculiar pattern of a rare pediatric presentation
ConclusionBSN treatment is similar to unilateral disease. A more conservative surgical approach with adrenal tissue preservation on less extensive side should be considered. Biological variables and extent of disease are amongst the most important prognostic determinants. Future studies are warranted to further address the biologic profiling of BSN and highlight prognostic significance of size difference between both adrenal sides. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 12, 2024 Category: Cancer & Oncology Source Type: research

CCN2/CTGF expression does not correlate with fibrosis in myeloproliferative neoplasms, consistent with noncanonical TGF- β signaling driving myelofibrosis
AbstractThe classicalBCR::ABL1-negative myeloproliferative neoplasms (MPN) form a group of bone marrow (BM) diseases with the potential to progress to acute myeloid leukemia or develop marrow fibrosis and subsequent BM failure. The mechanism by which BM fibrosis develops and the factors that drive stromal activation and fibrosis are not well understood. Cellular Communication Network 2 (CCN2), also known as CTGF (Connective Tissue Growth Factor), is a profibrotic matricellular protein functioning as an important driver and biomarker of fibrosis in a wide range of diseases outside the marrow. CCN2 can promote fibrosis direc...
Source: Virchows Archiv - April 11, 2024 Category: Pathology Source Type: research

Simultaneous blastic plasmacytoid dendritic cell neoplasm and myelofibrosis: A case report
Oncol Lett. 2024 Mar 22;27(5):220. doi: 10.3892/ol.2024.14354. eCollection 2024 May.ABSTRACTBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is an extremely rare and aggressive tumor with an unknown pathogenesis. Myelofibrosis (MF) is a type of myeloproliferative neoplasm. MF can be secondary to several hematological malignancies, including chronic myeloid leukemia, myelodysplastic syndrome and hairy cell leukemia. In the present report, a rare case of BPDCN secondary to MF is described. A 70-year-old male patient developed a large purplish-red rash with recurrent symptoms. BPDCN was confirmed by immunohistochemistry o...
Source: Oncology Letters - April 8, 2024 Category: Cancer & Oncology Authors: Fuyi Luo Bingjie Li Jing Li Yan Li Source Type: research

Nephronophthisis 13 caused by WDR19 variants with pancytopenia: case report
We present a case of nephronophthisis 13 that resulted fromWDR19 variants. The patient, a nine-year-old Japanese boy, had detection of mild proteinuria during a school urine screening. Urinalysis revealed mild proteinuria without hematuria. Blood tests indicated pancytopenia, mild elevation of liver enzymes, and kidney dysfunction. Ultrasound examination disclosed hepatosplenomegaly. Abdominal computed tomography and bone marrow assessments ruled out malignant tumors. Subsequent kidney and liver biopsies suggested nephronophthisis and congenital hepatic fibrosis. Furthermore, comprehensive genetic analysis through next-gen...
Source: CEN Case Reports - April 8, 2024 Category: Urology & Nephrology Source Type: research