Africa: Johnson & Johnson Must Halve Price of Lifesaving TB Drug Bedaquiline
[MSF] M édecins Sans Frontières (MSF) has launched a global campaign calling on pharmaceutical corporation Johnson& Johnson (J&J) to lower the price of its anti-tuberculosis medicine bedaquiline to no more than US$1 per day for people everywhere who need it, in order to allow scale-up of drug-resistant tuberculosis (DR-TB) treatment and reduce deaths. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 10, 2019 Category: African Health Source Type: news
FDA approves pretomanid tablets in combination with bedaquiline and linezolid for treatment of extensively drug resistant, treatment-intolerant or nonresponsive multidrug resistant pulmonary TB
Pretomanid is a new chemical entity and a member of a class of compounds known as nitroimidazooxazines. A successful outcome has been reported in 95 of the first 107 patients in trial after six months of treatment with this regimen and six months of post-treatment follow-up. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - August 16, 2019 Category: Consumer Health News Source Type: news
FDA approves new drug for treatment-resistant forms of tuberculosis that affects the lungs
The U.S. Food and Drug Administration today approved Pretomanid Tablets in combination with bedaquiline and linezolid for the treatment of a specific type of highly treatment-resistant tuberculosis (TB) of the lungs.
"The threat of antimicrobial-resistant infections is a key challenge we face as a public health agency," said FDA Principal Deputy Commissioner Amy Abernethy, M.D., Ph.D. (Source: World Pharma News)
Source: World Pharma News - August 15, 2019 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news
Pretomanid Approved for Treatment of Drug-Resistant TB
WEDNESDAY, Aug. 14, 2019 -- Pretomanid tablets in combination with bedaquiline and linezolid have been approved for the treatment of a highly treatment-resistant type of pulmonary tuberculosis (TB), the U.S. Food and Drug Administration announced... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - August 14, 2019 Category: General Medicine Source Type: news
Janssen Announces U.S. FDA Accelerated Approval for SIRTURO ® (bedaquiline) as Part of Combination Therapy to Treat Adolescents with Pulmonary Multidrug-Resistant Tuberculosis
(Source: Johnson and Johnson)
Source: Johnson and Johnson - August 9, 2019 Category: Pharmaceuticals Source Type: news
Janssen Announces U.S. FDA Accelerated Approval for Sirturo (bedaquiline) as Part of Combination Therapy to Treat Adolescents with Pulmonary Multidrug-Resistant Tuberculosis
TITUSVILLE, NJ, August 9, 2019— The Janssen Pharmaceutical Companies of Johnson& Johnson today announced that the U.S. Food and Drug Administration (FDA) has granted approval for Sirturo (bedaquiline) tablets as part of combination... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - August 9, 2019 Category: Drugs & Pharmacology Source Type: news
Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world’s deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means that it is unclear whether antibiotics penetrate all mycobacteria-containing compartments in the cell. Here, we combined correlated light, electron, and ion microscopy to image the distribution of bedaquiline in infected human macrophages at submicrometer resolution. Bedaquiline accumulated primarily in host cell lipid drop...
Source: ScienceNOW - June 26, 2019 Category: Science Authors: Greenwood, D. J., Dos Santos, M. S., Huang, S., Russell, M. R. G., Collinson, L. M., MacRae, J. I., West, A., Jiang, H., Gutierrez, M. G. Tags: Cell Biology reports Source Type: news
Outcomes of Bedaquiline Treatment in Multidrug-Resistant TB Outcomes of Bedaquiline Treatment in Multidrug-Resistant TB
What do we know about the treatment success rate of bedaquiline in multidrug-resistant tuberculosis?Emerging Infectious Diseases (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - June 7, 2019 Category: Infectious Diseases Tags: Infectious Diseases Journal Article Source Type: news
Stellenbosch University researchers study resistance to 'protect' anti-TB drug
(Stellenbosch University) Scientists from Stellenbosch University are trying to conserve the life-saving treatment bedaquiline, by studying how the bacterium that causes TB can develop resistance to this drug. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 30, 2019 Category: Infectious Diseases Source Type: news
Researchers identify faster, more effective drug combination regimens to treat tuberculosis
Tuberculosis is a potentially deadly though curable disease. Each year about 10 million people develop active cases, and 1.6 million people die. In addition, about 1.7 billion people around the world are infected with TB bacteria, which can lie dormant for weeks to years, then become active and cause disease in up to 10 percent of those who are infected.Today, people who contract tuberculosis typically take a course of drugs for six to eight months. However, the length of treatment means some patients don ’t stick with the therapy or may develop adverse effects from drug toxicity. Some may develop resistance to the drugs...
Source: UCLA Newsroom: Health Sciences - May 13, 2019 Category: Universities & Medical Training Source Type: news
Two TB survivors fight Johnson & Johnson monopoly bid
At present, only 2% of over 1.47 lakh patients suffering from multi drug resistant TB in India are currently getting Bedaquiline. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - February 9, 2019 Category: Pharmaceuticals Source Type: news
Tuberculosis CURED in 90% of cases with new drug hailed by doctors as 'game changer'
Doctors in Belarus tested the method, which uses the drug bedaquiline with other antibiotics, on 168 patients. The country has one of the highest rates of multidrug-resistant tuberculosis in the world. (Source: the Mail online | Health)
Source: the Mail online | Health - October 24, 2018 Category: Consumer Health News Source Type: news
Price of J & J ’s TB drug to drop by more than half
Life-saving drug bedaquiline by US pharma company Johnson& Johnson (J&J) is now being offered at $400 per patient —over 50% cheaper than the earlier price of $900. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - August 21, 2018 Category: Pharmaceuticals Source Type: news
World Health Organization recommends the use of bedaquiline in all conventional multidrug-resistant tuberculosis treatment regimens
(Source: Johnson and Johnson)
Source: Johnson and Johnson - August 20, 2018 Category: Pharmaceuticals Source Type: news
