Outcomes of Bedaquiline Treatment in Multidrug-Resistant TB Outcomes of Bedaquiline Treatment in Multidrug-Resistant TB

What do we know about the treatment success rate of bedaquiline in multidrug-resistant tuberculosis?Emerging Infectious Diseases
Source: Medscape Hiv-Aids Headlines - Category: Infectious Diseases Tags: Infectious Diseases Journal Article Source Type: news

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CONCLUSIONS: Rifabutin should be available globally as a first-line rifamycin in HIV co-infected individuals and as a switch option in cases of rifampicin associated ADRs. Further studies are needed to ascertain the utility of rifabutin in rifampicin-resistant rifabutin-susceptible TB. PMID: 31318176 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
Conclusion: Younger children are more likely to develop TB within a year of presentation whereas those who were near the adolescent age group were more likely to develop TB after 3 years of diagnosis of HIV. Thus, role of IPT in adolescents for 3 years at the time of diagnosis may not be useful as they tend to develop TB later on whereas IPT may be useful in the younger age group. With high incidence of MDR-TB, role of IPT in HIV-infected children in India needs to be re-assessed.
Source: Indian Journal of Sexually Transmitted Diseases - Category: Infectious Diseases Authors: Source Type: research
A new study in patients with rifampin-resistant tuberculosis (TB) is providing the first strong evidence that the Bangladesh protocol for treating multidrug-resistant (MDR)-TB, which is used for 9 to 11 months, is not inferior to the standard regimen recommended by the World Health Organization, which requires treatment for 20 months.Reuters Health Information
Source: Medscape Hiv-Aids Headlines - Category: Infectious Diseases Tags: Infectious Diseases News Source Type: news
Van Lanen Mycobacterium tuberculosis (Mtb) has recently surpassed HIV/AIDS as the leading cause of death by a single infectious agent. The standard therapeutic regimen against tuberculosis (TB) remains a long, expensive process involving a multidrug regimen, and the prominence of multidrug-resistant (MDR), extensively drug-resistant (XDR), and totally drug-resistant (TDR) strains continues to impede treatment success. An underexplored class of natural products—the capuramycin-type nucleoside antibiotics—have been shown to have potent anti-TB activity by inhibiting bacterial translocase I, a ubiquit...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
(CNN) — From climate change to superbugs, the World Health Organization has laid out 10 big threats to our global health in 2019. And unless these threats get addressed, millions of lives will be in jeopardy. Here’s a snapshot of 10 urgent health issues, according to the United Nations’ public health agency: Not vaccinating when you can One of the most controversial recent health topics in the US is now an international concern. “Vaccine hesitancy — the reluctance or refusal to vaccinate despite the availability of vaccines — threatens to reverse progress made in tackling vaccine-prevent...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Local TV Source Type: news
In conclusion, the increase in predisposing risk factors for catching TB, especially the migration and Beijing strain, shows that in the absence of accurate monitoring, TB cases will increase in the near future in Iran. PMID: 30592256 [PubMed - as supplied by publisher]
Source: Infectious Disorders Drug Targets - Category: Infectious Diseases Authors: Tags: Infect Disord Drug Targets Source Type: research
Conclusions: In a country with high TB incidence, such as the RM, the phisicians shall manifest an increased vigilance to pregnant women showing the suggestive symptoms of TB.References:1. Bothlamey, G.H el al. MBC Pregnancy and Childbirth 2016 16:304Abreviations:MDRTB-Multidrug-resistant TBRM-Republic of Moldova
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
Purpose of review This review aims to describe the key principles in treatment of drug-resistant tuberculosis (TB) in people living with HIV, including early access to timely diagnostics, linkage into care, TB treatment strategies including the use of new and repurposed drugs, co-management of HIV disease, and treatment complications and programmatic support to optimize treatment outcomes. These are necessary strategies to decrease the likelihood of poor treatment outcomes including lower treatment completion rates and higher mortality. Recent findings Diagnosis of drug-resistant TB is the gateway into care; yet under...
Source: Current Opinion in HIV and AIDS - Category: Infectious Diseases Tags: TUBERCULOSIS AND HIV: Edited by Richard E. Chaisson and Haileyesus Getahun Source Type: research
Purpose of review In the past few years, tuberculosis (TB) has overtaken HIV as the infectious disease with the highest global mortality. Successful management of this syndemic will require improved diagnostic tests, shorter preventive therapies, and more effective treatments, particularly in light of drug-resistant TB. Recent findings Results from several major studies have been published or presented recently, including the development of a more sensitive rapid, molecular assay for TB; several new symptom-based screening tools; use of a 1-month regimen for TB prevention; the results of early vs. delayed TB preventiv...
Source: Current Opinion in HIV and AIDS - Category: Infectious Diseases Tags: TUBERCULOSIS AND HIV: Edited by Richard E. Chaisson and Haileyesus Getahun Source Type: research
Purpose of review The aim of this review is to highlight recent changes in opportunistic ocular infections (OOIs) in the era of modern combination antiretroviral therapy (cART), in the setting of HIV-infected patients. Recent findings Improvements in modern cART has led to a progressive decline in the incidence of OOIs and mortality among patients with AIDS. Not only has there been a decreasing incidence of cytomegalovirus (CMV) retinitis, but there also has been a decline in progression of such retinitis when it does occur in AIDS patients, since the introduction of cART. Nevertheless, CMV retinitis remains the major...
Source: Current Opinion in Ophthalmology - Category: Opthalmology Tags: OCULAR MANIFESTATIONS OF SYSTEMIC DISEASE: Edited by John A. Gonzales Source Type: research
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