FDA approves pretomanid tablets in combination with bedaquiline and linezolid for treatment of extensively drug resistant, treatment-intolerant or nonresponsive multidrug resistant pulmonary TB

Pretomanid is a new chemical entity and a member of a class of compounds known as nitroimidazooxazines. A successful outcome has been reported in 95 of the first 107 patients in trial after six months of treatment with this regimen and six months of post-treatment follow-up.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Conditions:   Maternal Sepsis;   Intensive Care Units;   Drug Resistance, Multiple Intervention:   Other: Multidrug-resistant bacteria Sponsors:   Peking University Third Hospital;   Beijing Chao Yang Hospital;   Beijing Friendship Hospital Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study was applied to investigate the prevalence of A. hydrophila in diseased Nile tilapia fish, genetic characterization of the virulence encoding genes (act, aerA, alt, and ast genes), and antibiotic susceptibility. Out of the 500 diseased Nile tilapia fish samples, 70% (350/500) Aeromonas species were isolated. From which 53.4% (187/350) of Aeromonas hydrophila strains were identified. A. hydrophila was detected in kidneys, followed by liver, spleen, intestine, and gills. The results of virulotyping displayed the presence of act, and aerA genes in a high percentage of 40%, followed by alt gene (30%), but ast gene wa...
Source: Biocontrol Science - Category: Microbiology Authors: Source Type: research
Iran J Microbiol. 2021 Aug;13(4):470-479. doi: 10.18502/ijm.v13i4.6971.ABSTRACTBACKGROUND AND OBJECTIVES: Non-fermentative Gram-negative Bacilli (NFGNB) is known as a major cause of healthcare-associated infections with high levels of antibiotic resistance. The aim of this study was to investigate the antibiotic resistance profiles and molecular characteristics of metallo-beta-lactamase (MBL)-producing NFGNB.MATERIALS AND METHODS: In this cross-sectional study, the antibiotic resistance profile of 122 clinical NFGNB isolates was determined by the Kirby-Bauer disk diffusion and microdilution broth methods. Bacterial isolate...
Source: Iranian Journal of Microbiology - Category: Microbiology Authors: Source Type: research
Escherichia coli is a common bacterium in the intestines of animals, and it is also the major important cause of toxic mastitis, which is an acute or peracute disease that causes a higher incidence of death and culling of cattle. The purpose of this study was to investigate E. coli strains isolated from the raw milk of dairy cattle in Northern China, and the antibacterial susceptibility of these strains and essential virulence genes. From May to September 2015, 195 raw milk samples were collected from 195 dairy farms located in Northern China. Among the samples, 67 (34.4%) samples were positive for E. coli. About 67 E. col...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In conclusion, GA alleviates the hepatotoxicity caused by ANIT by regulating bile acids transporters, inflammation and apoptosis, which suggests that GA may be a potential therapeutic agent for cholestasis.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, we established an in vitro model of MDR in ovarian cancer and suggested MRP7 overexpression as the leading mechanism of chemoresistance in this cell line. Our results demonstrated the potential relationship between MRP7 and ovarian cancer MDR.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
u Zeng Tian Xie Malignant tumors are life-threatening, and chemotherapy is one of the common treatment methods. However, there are often many factors that contribute to the failure of chemotherapy. The multidrug resistance of cancer cells during chemotherapy has been reported, since tumor cells’ sensitivity decreases over time. To overcome these problems, extensive studies have been conducted to reverse drug resistance in tumor cells. Elemene, an extract of the natural drug Curcuma wenyujin, has been found to reverse drug resistance and sensitize cancer cells to chemotherapy. Mechanisms by which elemene reverse...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Arch Microbiol. 2021 Sep 23. doi: 10.1007/s00203-021-02579-x. Online ahead of print.ABSTRACTA total of 220 birds of age ranging from 3 to 14 weeks old were collected from several backyards and different farms in Sharkia Governorate, Egypt, and surveyed for the presence of fowl cholera. Twenty Pasteurella multocida from chickens (15/145, 10%) and ducks (5/75, 6%) were bacteriologically isolated, and it was shown that the infection was significantly related to age and breed. Capsular typing, using multiplex polymerase chain reaction (PCR), demonstrated that all strains were type A (100%). Disk diffusion assay towards ten ant...
Source: Archives of Microbiology - Category: Microbiology Authors: Source Type: research
World J Hepatol. 2021 Aug 27;13(8):840-852. doi: 10.4254/wjh.v13.i8.840.ABSTRACTPatients with cirrhosis show an increased susceptibility to infection due to disease-related immune-dysfunction. Bacterial infection therefore represents a common, often detrimental event in patients with advanced liver disease, since it can worsen portal hypertension and impair the function of hepatic and extra-hepatic organs. Among pharmacological strategies to prevent infection, antibiotic prophylaxis remains the first-choice, especially in high-risk groups, such as patients with acute variceal bleeding, low ascitic fluid proteins, and prior...
Source: World Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
An Acad Bras Cienc. 2021 Sep 20;93(suppl 3):e20210245. doi: 10.1590/0001-3765202120210245. eCollection 2021.ABSTRACTThe aim of this study was to evaluate the phenotypic and molecular patterns of biofilm formation in infection and colonization isolates of Acinetobacter spp. from patients who were admitted in a public hospital of Recife-PE-Brazil in 2018-2019. For the biofilm phenotypic analysis, Acinetobacter spp. isolates were evaluated by the crystal violet staining method; the search of virulence genes (bap, ompA, epsA, csuE and bfmS) was performed by PCR; and the ERIC-PCR was performed for molecular typing. Amongst the ...
Source: An Acad Bras Cienc - Category: Science Authors: Source Type: research
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