Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment
Cancer Res Commun. 2024 Apr 8;4(4):1004-1015. doi: 10.1158/2767-9764.CRC-23-0423.ABSTRACTAsbestos and BAP1 germline mutations are risk factors for malignant mesothelioma (MM). While it is well accepted that amphibole asbestos is carcinogenic, the role of serpentine (chrysotile) asbestos in MM has been debated. To address this controversy, we assessed whether minimal exposure to chrysotile could significantly increase the incidence and rate of MM onset in germline Bap1-mutant mice. With either crocidolite or chrysotile, and at each dose tested, MMs occurred at a significantly higher rate and earlier onset time in Bap1-mutan...
Source: Cancer Control - April 9, 2024 Category: Cancer & Oncology Authors: Yuwaraj Kadariya Eleonora Sementino Maggie Ruan Mitchell Cheung Parham Hadikhani Hatice U Osmanbeyoglu Andres J Klein-Szanto Kathy Cai Joseph R Testa Source Type: research
Guidelines for Pathologic Diagnosis of Mesothelioma
CONCLUSIONS.—: There was consensus opinion regarding guidelines for (1) histomorphologic diagnosis of mesothelial tumors, including distinction of epithelioid, biphasic, and sarcomatoid mesothelioma; recognition of morphologic variants and patterns; and recognition of common morphologic pitfalls; (2) molecular pathogenesis of mesothelioma; (3) application of immunohistochemical markers to establish mesothelial lineage and distinguish mesothelioma from common morphologic differentials; (4) application of ancillary studies to distinguish benign from malignant mesothelial proliferations, including BAP1 and MTAP immunostains...
Source: Archives of Pathology and Laboratory Medicine - April 8, 2024 Category: Laboratory Medicine Authors: Aliya N Husain David B Chapel Richard Attanoos Mary Beth Beasley Luka Brcic Kelly Butnor Lucian R Chirieac Andrew Churg Sanja Dacic Francoise Galateau-Salle Kenzo Hiroshima Yin P Hung Sonja Klebe Thomas Krausz Andras Khoor Leslie Litzky Alberto Marchevsky Source Type: research
Guidelines for Pathologic Diagnosis of Mesothelioma
CONCLUSIONS.—: There was consensus opinion regarding guidelines for (1) histomorphologic diagnosis of mesothelial tumors, including distinction of epithelioid, biphasic, and sarcomatoid mesothelioma; recognition of morphologic variants and patterns; and recognition of common morphologic pitfalls; (2) molecular pathogenesis of mesothelioma; (3) application of immunohistochemical markers to establish mesothelial lineage and distinguish mesothelioma from common morphologic differentials; (4) application of ancillary studies to distinguish benign from malignant mesothelial proliferations, including BAP1 and MTAP immunostains...
Source: Archives of Pathology and Laboratory Medicine - April 8, 2024 Category: Laboratory Medicine Authors: Aliya N Husain David B Chapel Richard Attanoos Mary Beth Beasley Luka Brcic Kelly Butnor Lucian R Chirieac Andrew Churg Sanja Dacic Francoise Galateau-Salle Kenzo Hiroshima Yin P Hung Sonja Klebe Thomas Krausz Andras Khoor Leslie Litzky Alberto Marchevsky Source Type: research
Guidelines for Pathologic Diagnosis of Mesothelioma
CONCLUSIONS.—: There was consensus opinion regarding guidelines for (1) histomorphologic diagnosis of mesothelial tumors, including distinction of epithelioid, biphasic, and sarcomatoid mesothelioma; recognition of morphologic variants and patterns; and recognition of common morphologic pitfalls; (2) molecular pathogenesis of mesothelioma; (3) application of immunohistochemical markers to establish mesothelial lineage and distinguish mesothelioma from common morphologic differentials; (4) application of ancillary studies to distinguish benign from malignant mesothelial proliferations, including BAP1 and MTAP immunostains...
Source: Archives of Pathology and Laboratory Medicine - April 8, 2024 Category: Laboratory Medicine Authors: Aliya N Husain David B Chapel Richard Attanoos Mary Beth Beasley Luka Brcic Kelly Butnor Lucian R Chirieac Andrew Churg Sanja Dacic Francoise Galateau-Salle Kenzo Hiroshima Yin P Hung Sonja Klebe Thomas Krausz Andras Khoor Leslie Litzky Alberto Marchevsky Source Type: research
The presence of erionite in North American geologies and the estimated mesothelioma potency by region
CONCLUSION: The model predicted mesothelioma potency of Turkish erionite (4.53) falls in this same range of potencies as erionite found in North America. Although it can vary by region, a reasonable ratio of average mesothelioma potency based on this model is 3,000:500:100:1 comparing North American erionite, crocidolite, amosite, and chrysotile (from most potent to least potent).PMID:38583132 | DOI:10.1080/08958378.2024.2322496 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - April 7, 2024 Category: Respiratory Medicine Authors: Michael E Stevens Dennis J Paustenbach Noah J Lockhart Dalton E Busboom Blake M Deckard David W Brew Source Type: research
Surgical resection for pleural mesothelioma: Is it all about patient selection?
Ann Thorac Surg. 2024 Apr 5:S0003-4975(24)00256-X. doi: 10.1016/j.athoracsur.2024.03.026. Online ahead of print.NO ABSTRACTPMID:38583514 | DOI:10.1016/j.athoracsur.2024.03.026 (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - April 7, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Valerie W Rusch Source Type: research
The presence of erionite in North American geologies and the estimated mesothelioma potency by region
CONCLUSION: The model predicted mesothelioma potency of Turkish erionite (4.53) falls in this same range of potencies as erionite found in North America. Although it can vary by region, a reasonable ratio of average mesothelioma potency based on this model is 3,000:500:100:1 comparing North American erionite, crocidolite, amosite, and chrysotile (from most potent to least potent).PMID:38583132 | DOI:10.1080/08958378.2024.2322496 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - April 7, 2024 Category: Respiratory Medicine Authors: Michael E Stevens Dennis J Paustenbach Noah J Lockhart Dalton E Busboom Blake M Deckard David W Brew Source Type: research
Surgical resection for pleural mesothelioma: Is it all about patient selection?
Ann Thorac Surg. 2024 Apr 5:S0003-4975(24)00256-X. doi: 10.1016/j.athoracsur.2024.03.026. Online ahead of print.NO ABSTRACTPMID:38583514 | DOI:10.1016/j.athoracsur.2024.03.026 (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - April 7, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Valerie W Rusch Source Type: research
The presence of erionite in North American geologies and the estimated mesothelioma potency by region
CONCLUSION: The model predicted mesothelioma potency of Turkish erionite (4.53) falls in this same range of potencies as erionite found in North America. Although it can vary by region, a reasonable ratio of average mesothelioma potency based on this model is 3,000:500:100:1 comparing North American erionite, crocidolite, amosite, and chrysotile (from most potent to least potent).PMID:38583132 | DOI:10.1080/08958378.2024.2322496 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - April 7, 2024 Category: Respiratory Medicine Authors: Michael E Stevens Dennis J Paustenbach Noah J Lockhart Dalton E Busboom Blake M Deckard David W Brew Source Type: research
Surgical resection for pleural mesothelioma: Is it all about patient selection?
Ann Thorac Surg. 2024 Apr 5:S0003-4975(24)00256-X. doi: 10.1016/j.athoracsur.2024.03.026. Online ahead of print.NO ABSTRACTPMID:38583514 | DOI:10.1016/j.athoracsur.2024.03.026 (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - April 7, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Valerie W Rusch Source Type: research
The presence of erionite in North American geologies and the estimated mesothelioma potency by region
CONCLUSION: The model predicted mesothelioma potency of Turkish erionite (4.53) falls in this same range of potencies as erionite found in North America. Although it can vary by region, a reasonable ratio of average mesothelioma potency based on this model is 3,000:500:100:1 comparing North American erionite, crocidolite, amosite, and chrysotile (from most potent to least potent).PMID:38583132 | DOI:10.1080/08958378.2024.2322496 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - April 7, 2024 Category: Respiratory Medicine Authors: Michael E Stevens Dennis J Paustenbach Noah J Lockhart Dalton E Busboom Blake M Deckard David W Brew Source Type: research
Surgical resection for pleural mesothelioma: Is it all about patient selection?
Ann Thorac Surg. 2024 Apr 5:S0003-4975(24)00256-X. doi: 10.1016/j.athoracsur.2024.03.026. Online ahead of print.NO ABSTRACTPMID:38583514 | DOI:10.1016/j.athoracsur.2024.03.026 (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - April 7, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Valerie W Rusch Source Type: research
The presence of erionite in North American geologies and the estimated mesothelioma potency by region
CONCLUSION: The model predicted mesothelioma potency of Turkish erionite (4.53) falls in this same range of potencies as erionite found in North America. Although it can vary by region, a reasonable ratio of average mesothelioma potency based on this model is 3,000:500:100:1 comparing North American erionite, crocidolite, amosite, and chrysotile (from most potent to least potent).PMID:38583132 | DOI:10.1080/08958378.2024.2322496 (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - April 7, 2024 Category: Respiratory Medicine Authors: Michael E Stevens Dennis J Paustenbach Noah J Lockhart Dalton E Busboom Blake M Deckard David W Brew Source Type: research
