Mental health and wellbeing in mesothelioma: A qualitative study exploring what helps the wellbeing of those living with this illness and their informal carers
Mesothelioma is an incurable, asbestos related cancer with a poor prognosis. Little is known about how patients and carers living with the condition manage their mental health and wellbeing needs. This paper reports findings on interventions being used by patients and informal carers living with mesothelioma and those which they find most helpful. (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - March 22, 2024 Category: Cancer & Oncology Authors: Stephanie Ejegi-Memeh, Virginia Sherborne, Catriona Mayland, Angela Tod, Bethany H. Taylor Source Type: research
Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma
British Journal of Cancer, Published online: 22 March 2024; doi:10.1038/s41416-024-02661-3Combination of EZH2 and ATM inhibition in BAP1-deficient mesothelioma (Source: British Journal of Cancer)
Source: British Journal of Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Nick Landman Danielle Hulsman Jitendra Badhai Jawahar Kopparam Julian Puppe Gaurav Kumar Pandey Maarten van Lohuizen Source Type: research
Cancers, Vol. 16, Pages 1252: Emerging New Targets in Systemic Therapy for Malignant Pleural Mesothelioma
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Malignant pleural mesothelioma (MPM) is a heterogeneous cancer composed of distinct molecular and pathologic subtypes. Unfortunately, MPM is aggressive, and current therapies for advanced, unresectable disease remain limited to cytotoxic chemotherapy and immunotherapy. Our understanding of the genomic landscape of MPM is steadily growing, while the discovery of effective targeted therapies in MPM has advanced more slowly than in other solid tumors. Given the prevalence of alterations in tumor suppressor genes in MPM, it has been challenging to identify actionable targets. However, efforts to characterize the geneti...
Source: Cancers - March 22, 2024 Category: Cancer & Oncology Authors: Karen M. Yun Lyudmila Bazhenova Tags: Review Source Type: research
Complex Genomic Rearrangement Patterns in Malignant Pleural Mesothelioma due to Environmental Asbestos Exposure
In this study, we aimed to characterize complex genomic rearrangement patterns and variations to better understand the genomics of MPM tumors. We comparatively scanned 3 MPM tumor genomes by Whole-Genome Sequencing and High-Resolution SNP array. We also used various computational algorithms to detect both CNAs and complex chromosomal rearrangements. Genomic data obtained from each bioinformatics tool are interpreted comparatively to better understand CNAs and cancer-related Nucleotide variations in MPM tumors. In patients 1 and 2, we found pathogenic nucleotide variants of BAP1, RB1, and TP53. These two MPM genomes exhibit...
Source: Journal of Environmental Pathology, Toxicology and Oncology - March 20, 2024 Category: Environmental Health Authors: Tun ç Tuncel G üntülü Ak Hasan Veysi G üneş Muzaffer Metinta ş Source Type: research
