A Look Back at 2022: Progress Towards the Treatment of Aging as a Medical Condition
At the end of 2022, we can reflect on the fact that we are steadily entering a new era of medicine, one in which mechanisms of aging are targeted rather than ignored. It is a profound change, one that will change the shape of a human life and ultimately the human condition by eliminating the greatest sources of suffering and death in the world. Year after year, we see increased funding, ongoing progress towards therapies capable of slowing aging or reversing aspects of aging, and a growing taxonomy of such potential therapies and their target mechanisms.
The view of aging in the medical community and public at large...
Source: Fight Aging! - December 30, 2022 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Fight Aging! Newsletter, December 5th 2022
In conclusion, the PAAIs examined (i.e. mTOR loss of function, Ghrhr loss of function, intermittent fasting-based version of dietary restriction) often influenced age-sensitive traits in a direct way and not by slowing age-dependent change. Previous studies often failed to include young animals subjected to PAAI to account for age-independent PAAI effects. However, any study not accounting for such age-independent intervention effects will be prone to overestimate the extent to which an intervention delays the effects of aging on the phenotypes studied. This can result in a considerable bias of our view on how modifiable a...
Source: Fight Aging! - December 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Galectins in Neuroinflammation, a Potential Target
We describe the role of Gals in microglia and astrocyte modulation, along with their pro- and anti-inflammatory functions. In addition, we discuss the potential use of Gals as a novel therapeutic target for neuroinflammation and restoring tissue damage in neurodegenerative diseases. (Source: Fight Aging!)
Source: Fight Aging! - December 1, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reviewing the Contribution of the Gut Microbiome to Neurodegeneration
The state of the gut microbiome is probably as influential as the state of physical fitness when it comes to effects on long-term health. With age the balance of microbial populations shifts for the worse, in fact one of the earlier detrimental aspects of aging. Studies suggest that meaningful changes are in evidence by the time someone reaches their mid-30s. Beneficial species producing metabolites that contribute to tissue function diminish in number, while harmful species that provoke chronic inflammation increase in number.
Fortunately, it is possible to adjust the gut microbiome, to rejuvenate it and restore a ...
Source: Fight Aging! - November 30, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Implantable Device Adheres to Muscle, Treats Atrophy
This study by Dave Mooney and his group is a very elegant and forward-looking example of how this type of mechanotherapy could be used clinically in the future.”
The MAGENTA device with its tough hydrogel adhesive surface (shown on the left) was implanted on a mouse’s calf muscle that in the atrophy model then was immobilized for a longer period of time to induce muscle wasting. Actuating the device by turning the electricity on lets it contract, generating mechanical stimulation to the underlying muscle, whereas turning the electricity off allows the device and muscle to relax (top row on the right). The pa...
Source: Medgadget - November 16, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Orthopedic Surgery Rehab muscle atrophy wyssinstitute Source Type: blogs
Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Is Cellular Senescence Involved in ALS?
In this study, we used a two-stage approach to first investigate the immunophenotype of PBMCs from individuals living with ALS and then focused on lymphocytes expressing known features of immunosenescence. We showed that lymphocytes from patients with ALS are skewed toward a senescent and late memory state when compared with those from age-matched healthy controls.
Link: https://doi.org/10.1212/NXI.0000000000200042 (Source: Fight Aging!)
Source: Fight Aging! - November 10, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 22nd 2022
In conclusion, application of a multi-species bat epigenetic clock provides strong evidence that hibernation is associated with slower epigenetic ageing. The multi-species clock explains 94% of the variation in the chronological ages of both hibernating and non-hibernating big brown bats; however, the clock estimates are equal to or greater than the chronological age, suggesting big brown bats age slightly faster than a 'typical' bat, especially during the active period. (Source: Fight Aging!)
Source: Fight Aging! - August 21, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Evidence for a Viral Contribution to Neurodegenerative Conditions
Are many of the common neurodegenerative conditions driven in their onset and progression by the consequences of persistent viral infection? The evidence is compelling, but not completely convincing at the present time. Given that these conditions are likely the result of a number of quite different, interacting mechanisms, including viral infection, vascular aging, immune system aging, mitochondrial dysfunction, and aggregation of toxic proteins, amongst others, it is a challenge to produce cut and dried data to show, definitively, the degree to which any one cause contributes. In the case of viral infection, there are st...
Source: Fight Aging! - August 18, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 25th 2022
This study further demonstrates that AMD is not a single condition or an isolated disease, but is often a signal of systemic malfunction which could benefit from targeted medical evaluation in addition to localized eye care."
Microglia in the Aging Brain, Both Protective and Harmful
https://www.fightaging.org/archives/2022/07/microglia-in-the-aging-brain-both-protective-and-harmful/
A growing body of evidence implicates the changing behavior of microglia in the aging of the brain and onset of neurodegeneration. Microglia are analogous to macrophages, innate immune cells unique to the central nervous sys...
Source: Fight Aging! - July 24, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
DNA Damage is a Part of Neural Plasticity, Complicating the Study of Its Relevance to Aging in the Brain
As noted by the authors of today's open access paper, there is ample evidence to show that double strand breaks in DNA occur during the normal activity of neurons, such as during the synaptic remodeling necessary to learning and memory. Evolution loves reuse, and few possibilities are ignored! This process of utilitarian double strand breaks appears to be used to ensure that nuclear DNA is spatially reconfigured in such a way as to ensure that certain genes are expressed for a time; recall that the pattern of gene expression at any given moment is very much a function of how the mass of nuclear DNA is packaged, which parts...
Source: Fight Aging! - July 21, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 4th 2022
This study showed that centenarians had very specific changes in CD4+ T cell populations, which were manifested by an elevated Th17/Treg ratio in vivo, as well as a changed secretory phenotype. Although the T cells of centenarians cannot resist the aging-related expression of proinflammatory genes, their secretory phenotype was altered, explaining the relatively low level of inflammation in centenarians. These results suggested the presence of a mechanism to ameliorate inflammaging in centenarians. This may be achieved by reversing the imbalance of Th17/Treg cells and reducing pro-inflammatory cytokines.
Longevit...
Source: Fight Aging! - July 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
PicnicHealth Raises a $60m Series C to Expand Patient-centered Real-world Data
PicnicHealth, a patient-centered health technology company, today announced the closing of a $60 million Series C financing led by new investor B Capital Group. Existing investors Felicis Ventures and Amplify Partners also joined the round, bringing the total PicnicHealth has raised to more than $100 million. The company also announced plans to build 30 new patient-centered real-world data cohorts, and the addition of Adam Seabrook, Partner at B Capital Group, to the PicnicHealth board of directors.
PicnicHealth takes a patient-centered approach to building deep real-world datasets for life sciences researchers. This compl...
Source: EMR and HIPAA - July 1, 2022 Category: Information Technology Authors: Healthcare IT News Tags: Analytics/Big Data Health IT Company Healthcare IT Adam Seabrook Amplify Partner B Capital Group Felicis Ventures Health IT Funding Health IT Fundings Health IT Investment Noga Leviner PicnicHealth Real-World Data Robert Mittendo Source Type: blogs
Cellular Senescence in the Midbrain in the Development of Parkinson's Disease
Senescent cells accumulate with age throughout the body. They secrete a potent mix of signals that provoke chronic inflammation and dysfunction in cells and tissues. It is becoming increasingly clear that senescent cells are involved in brain aging, and clearance of senescent cells from the brain has been shown in animal studies to reduce chronic inflammation and pathology in the context of neurodegenerative conditions. Here, researchers argue that senescent cells are implicated in the early stages of the development of Parkinson's disease. This is a hypothesis that could be readily tested in humans, given funding for a cl...
Source: Fight Aging! - June 29, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 27th 2022
In conclusion, this study confirms that innate immune training can be induced in aging healthy individuals as well as critically ill sepsis patients. We found that innate immune training can be induced regardless of age and there was no substantive difference in the immune trained phenotype as a function of age. We employed β-glucan as our immune training stimulus. The ability of glucan to induce the trained phenotype suggests that it may be possible to pharmacologically induce the immune trained phenotype in aging human immunocytes.
Sitting Time Correlates with Mortality Risk
https://www.fightaging.org/archi...
Source: Fight Aging! - June 26, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
