TWiV 889: COVID-19 clinical update #110 with Dr. Daniel Griffin
In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Hospital admissions during Omicron and Delta variant outbreaks (Lancet) Viral load in unvaccinat...
Source: This Week in Virology - MP3 Edition - April 16, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Coronapod: How African scientists are copying Moderna's COVID vaccine
Vaccine inequity continues to be one of the greatest challenges in the pandemic - with only 10% of those in low- and middle-income countries fully vaccinated. One of the biggest hold-ups is a lack of vaccine manufacturing capacity in poorer nations. But now, researchers at the WHO technology-transfer hub have completed the first step in a project aimed at building vaccine manufacturing capacity in the Global South, by successfully replicating Moderna's COVID vaccine without assistance from the US-based biotech company. In this episode of Coronapod, we ask how they did it? What happens next? What the legal ramification...
Source: Nature Podcast - February 11, 2022 Category: Science Authors: Springer Nature Limited Source Type: podcasts

Coronapod: How African scientists are copying Moderna's COVID vaccine
Vaccine inequity continues to be one of the greatest challenges in the pandemic - with only 10% of those in low- and middle-income countries fully vaccinated. One of the biggest hold-ups is a lack of vaccine manufacturing capacity in poorer nations. But now, researchers at the WHO technology-transfer hub have completed the first step in a project aimed at building vaccine manufacturing capacity in the Global South, by successfully replicating Moderna's COVID vaccine without assistance from the US-based biotech company. In this episode of Coronapod, we ask how they did it? What happens next? What the legal ramification...
Source: Nature Podcast - February 11, 2022 Category: Science Authors: Springer Nature Limited Source Type: podcasts

RNA test detects deadly pregnancy disorder early
RNA in blood reveals signs of pre-eclampsia before symptoms occur, and the issue of urine in our sewage and what can be done about it.In this episode:00:46 Predicting pre-eclampsiaCell-free RNA circulates in the blood and can give clues as to what is going on in the body. This can be used to detect disease before symptoms occur. Now researchers have analysed cell-free RNA in pregnant people and have found it can give early warning signs of a serious, and sometimes fatal, disorder of pregnancy — pre-eclampsia.Research Article: Moufarrej et al.07:19 Research HighlightsUpgrading machine vision by modelling it on human eyes,...
Source: Nature Podcast - February 9, 2022 Category: Science Authors: Springer Nature Limited Source Type: podcasts

TWiV 856: COVID-19 clinical update #98 with Dr. Daniel Griffin
In COVID-19 clinical update #98, Daniel Griffin reviews COVID-19 in South Africa, recognition of Omicron by ancestral T cells, booster effectiveness against disease, infection and vaccination in pregnant women, early Remdesivir to prevent progression to severe disease, management of hospitalized adults, Tocilizumab in hospitalized patients, vaccination and long COVID, and the true toll of the pandemic. Click arrow to play Download TWiV 853 (58 MB .mp3, 48 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19 in South Africa (pdf) Ancestral T cells recogn...
Source: This Week in Virology - MP3 Edition - January 22, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 850: COVID-19 clinical update #96 with Dr. Daniel Griffin
In COVID-19 clinical update #96, Daniel Griffin reviews Omicron in South Africa, rapid antigen tests, viral coinfections, isolation and quarantine, saliva preferred for Omicron, risk factors for severe disease in vaccinated, Paxlovid dosing, and long COVID. Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variant proportions (CDC) Omicron in South Africa (JAMA) Transmission of SARS-CoV-2 (Ann Int Med) Diagnostics for COVID-19 (Lancet) Comparison of rapid antigen tests (J Clin Med) Rapid antigen tests to reduce isolation (medRxiv) Frequency of viral confections (MMWR) Iso...
Source: This Week in Virology - MP3 Edition - January 8, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

TWiV 843: COVID-19 clinical update #93 with Dr. Daniel Griffin
In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistence of memory B cells in the elderly, infection and vaccine induced immunity, protection against severe illness and death by a third mRNA vaccine dose, high flow oxygen versus intubation, and therapeutic anticoagulation. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Variant updates (CDC) List of diagnostic kits (Global Fund, pd...
Source: This Week in Virology - MP3 Edition - December 18, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts

Audio long-read: How dangerous is Africa ’s explosive Lake Kivu?
Lake Kivu, nestled between the Democratic Republic of the Congo and Rwanda, is a geological anomaly that holds 300 cubic kilometres of dissolved carbon dioxide and 60 cubic kilometres of methane.The lake has the potential to explosively release these gases, which could fill the surrounding valley, potentially killing millions of people.Researchers are trying to establish the likelihood of such an event happening, and the best way to safely siphon the gases from the lake.This is an audio version of our feature: How dangerous is Africa’s explosive Lake Kivu? See acast.com/privacy for privacy and opt-out information. (Source: Nature Podcast)
Source: Nature Podcast - November 8, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts

Audio long-read: How dangerous is Africa ’s explosive Lake Kivu?
Lake Kivu, nestled between the Democratic Republic of the Congo and Rwanda, is a geological anomaly that holds 300 cubic kilometres of dissolved carbon dioxide and 60 cubic kilometres of methane.The lake has the potential to explosively release these gases, which could fill the surrounding valley, potentially killing millions of people.Researchers are trying to establish the likelihood of such an event happening, and the best way to safely siphon the gases from the lake.This is an audio version of our feature: How dangerous is Africa’s explosive Lake Kivu?  See acast.com/privacy for privacy and opt-out informat...
Source: Nature Podcast - November 8, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts

COP26: inequality in climate research
Why are the countries which currently suffer the most direct health impacts from climate change some of the least likely to publish climate research? In the lead-up to COP26, Prof. Penny Murage of LSHTM discusses the field and her community work in sub-Saharan Africa, and Ayesha Tandon of CarbonBrief talks about her recent piece on inequality in climate research. (Source: Listen to The Lancet)
Source: Listen to The Lancet - October 29, 2021 Category: General Medicine Authors: The Lancet Source Type: podcasts

Covid in south Asia - India and Nepal
In this podcast series, Kamran Abassi, executive editor of The BMJ will convene experts from South Asia to discuss how the pandemic has affected the region, how measures like lock-down and vaccination have been handled, and the impact of the pandemic on the social determinants of health. In this first podcast, we're focussing on India and Nepal, and are joined by; Srinath Reddy, president of the Public Health Foundation of India. Biraj Swain, who works in global development in Asia and East Africa, is a senior media critic and Buddha Basnyat, director of the Oxford University Clinical Research Unit in Nepal. For mo...
Source: The BMJ Podcast - October 17, 2021 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts

Covid in south Asia - India and Nepal
In this podcast series, Kamran Abbasi, executive editor of The BMJ will convene experts from South Asia to discuss how the pandemic has affected the region, how measures like lock-down and vaccination have been handled, and the impact of the pandemic on the social determinants of health. In this first podcast, we're focussing on India and Nepal, and are joined by; Srinath Reddy, president of the Public Health Foundation of India. Biraj Swain, who works in global development in Asia and East Africa, is a senior media critic and Buddha Basnyat, director of the Oxford University Clinical Research Unit in Nepal. For mo...
Source: The BMJ Podcast - October 17, 2021 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts

Covid in south Asia - India and Nepal
In this podcast series, Kamran Abbasi, executive editor of The BMJ will convene experts from South Asia to discuss how the pandemic has affected the region, how measures like lock-down and vaccination have been handled, and the impact of the pandemic on the social determinants of health. In this first podcast, we're focussing on India and Nepal, and are joined by; Srinath Reddy, president of the Public Health Foundation of India. Biraj Swain, who works in global development in Asia and East Africa, is a senior media critic and Buddha Basnyat, director of the Oxford University Clinical Research Unit in Nepal. For mor...
Source: The BMJ Podcast - October 17, 2021 Category: General Medicine Authors: BMJ Group Source Type: podcasts

TWiV 806: COVID-19 clinical update #80 with Dr. Daniel Griffin
In COVID-19 clinical update #80, Daniel Griffin reviews infections in children, masking, testing to limit transmission, high barrier for monoclonal antibody escape, are boosters needed, use of steroids, grants for long COVID, and how the pandemic unfolds in Africa. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Hospitalization pre- and post-vaccines (Res Sq) Infection in children (medRxiv) Updated mask guidance (CDC) Transmission to masked and unmasked (MMWR) Daily testing in schools (Lancet) High barrier to mAb esca...
Source: This Week in Virology - MP3 Edition - September 18, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts