Spike In Dolphin Deaths Directly Tied To Deepwater Horizon Oil Spill, Researchers Say
A dramatic increase in dolphin deaths in the Gulf of Mexico is directly linked to the Deepwater Horizon oil spill, scientists concluded in a report published Wednesday.
Following the 2010 explosion on the drilling rig owned by British Petroleum (BP) and the subsequent spill of 4.9 million barrels (205.8 million gallons) of oil into the ocean, scientists have documented 1,281 dead and stranded cetaceans, primarily bottlenose dolphins, along the northern coast of the Gulf of Mexico.
In this photo taken May 10, 2015, a dead dolphin washes ashore in the Gulf of Mexico on Grand Isle, Louisiana.
In 2011, Louisiana saw 163 do...
Source: Science - The Huffington Post - May 20, 2015 Category: Science Source Type: news
How Do You Treat Adrenal Crisis?
Discussion
Septo-optic dysplasia (SOD) is a disorder of midline prosencephalic development early in gestation. It causes agenesis of the septum pellucidum and/or thinning or absence of the corpus callosum and pituitary hormone deficiencies. It has an incidence of 1:10,000 live births. Most cases appear to be due to a combination of genetic and environmental factors but there are rare familial cases which are most often autosomal recessive.
The phenotype is variable and diagnosis can occur at birth with more severe problems or later with milder ones. Patients must have at least 2 of 3 problems for diagnosis including uni- ...
Source: PediatricEducation.org - May 4, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Management of adrenal crisis
Adrenal crisis (AC) is a life-threatening emergency that may occur in patients with chronic adrenal insufficiency (AI). Due to the rarity of AI, physicians are often unfamiliar with the correct emergency treatment of AC. However, objective data supporting this assumption are lacking.
Hahner et al. conducted a prospective study to assess the current management of AC with a special focus on the time needed for initiation of parenteral glucocorticoid treatment in a well characterised cohort of patients with chronic AI and compared the results with expert opinion on optimal time targets and time limits in AC.
Their data demo...
Source: Society for Endocrinology - April 27, 2015 Category: Endocrinology Source Type: news
Opioid EndocrinopathyOpioid Endocrinopathy
Are opioids adverse effects more of a "pain" than you realized? Learn how opioids may be associated with hypogonadism, adrenal insufficiency, and other endocrine disorders. Endocrine Practice (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 3, 2015 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
High rates of adrenal crisis seen in patients with chronic insufficiency
A prospective study carried out by researchers at the University of Wuerzburg has found that adrenal crisis occurs in a large proportion of patients with chronic adrenal insufficiency, even if they are educated about managing the disease; the study was published this week in The Journal of Clinical Endocrinology & Metabolism. Healio
(Source: Society for Endocrinology)
Source: Society for Endocrinology - December 10, 2014 Category: Endocrinology Source Type: news
Adrenal insufficiency - 2014 Lancet review
Adrenal insufficiency is the deficient production or action of glucocorticoids, with or without deficiency also in mineralocorticoids and adrenal androgens. It is a life-threatening disorder that can result from:- primary adrenal failure- secondary adrenal disease due to impairment of the hypothalamic—pituitary axis Prompt diagnosis and management are essential. The clinical manifestations of primary adrenal insufficiency result from deficiency of all adrenocortical hormones, but they can also include signs of other concurrent autoimmune conditions. In secondary or tertiary adrenal insufficiency, the clinical picture res...
Source: Clinical Cases and Images - November 12, 2014 Category: Journals (General) Tags: Endocrinology Lancet Source Type: news
Evaluation of adrenal function in critically ill children
The activation of the hypothalamic-pituitary-adrenal axis in response to critical illness and the resulting release of cortisol
from the adrenal cortex are essential to stress adaptation and maintenance of cardiovascular homeostasis. However, there is no consensus on adequate adrenal response to critical illness.
Balbão et al., conducted a prospective study to evaluate adrenal function in critically ill children compared with a control group of healthy children by measuring salivary cortisol and serum total cortisol at baseline and after ACTH stimulation test. Another ...
Source: Society for Endocrinology - October 21, 2014 Category: Endocrinology Source Type: news
5ɑ-reductase and adrenal insufficiency
Patients with critical illness or hepatic failure exhibit impaired cortisol response to ACTH, or ‘relative adrenal insufficiency’. The mechanism could be that elevated bile acids inhibit inactivation of cortisol in liver by 5α-reductases, leading to downregulation of the hypothalamic–pituitary–adrenal axis and adrenocortical atrophy. Livingstone and colleagues investigated the consequences of 5α-reductase type 1 deficiency in mice. Their results confirm that impaired peripheral clearance of glucocorticoids can cause ‘relative adrenal insufficiency&rs...
Source: Society for Endocrinology - August 29, 2014 Category: Endocrinology Source Type: news
Wednesday's pick of the day
Today sees our two nurses' sessions, as well as two more Plenary Lectures together with a further satellite symposia New insights in the management of adrenal insufficiency and the importance of circadian rhythm, sponsored by ViraPharma
Make sure you're up and about for our first ever Society for Endocrinology Journal Awards. Five authors of winning papers from the Society's five official journals will present their work from 8am in room 1C.
We're also looking forward to our second Education Workshop: Practical publishing advice at 9.30, room 3B in which seven speakers ...
Source: Society for Endocrinology - March 26, 2014 Category: Endocrinology Source Type: news
Boy who could be killed by argument: Morgan Taylor's body could shut down in stressful event
Four-year-old Morgan Taylor, from Burnley, has adrenal insufficiency which means his body does not produce the stress hormone cortisol. (Source: the Mail online | Health)
Source: the Mail online | Health - October 8, 2013 Category: Consumer Health News Source Type: news
What Is the Best Approach to Tailoring Hydrocortisone Dose?What Is the Best Approach to Tailoring Hydrocortisone Dose?
Do you consider circadian rhythm when dosing hydrocortisone for patients with adrenal insufficiency? Clinical Endocrinology (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - May 3, 2013 Category: Endocrinology Tags: Diabetes & Endocrinology Journal Article Source Type: news
Predictive Factors of Adrenal InsufficiencyPredictive Factors of Adrenal Insufficiency
What is the strongest predictor for potential adrenal failure? BMC Endocrine Disorders (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 28, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
What Causes Hypercalcemia?
Discussion
Calcium homeostasis is regulated by mechanisms involving the absorption from the gastrointestinal tract, bone deposition and resorption, and renal excretion. To review Vitamin D homeostasis click here.
Serum calcium is found in three forms: free (47%), protein bound (43%) and diffusable calcium complexes (10%). The protein binding proteins are albumin (80%) and globulin (20%). The free calcium is the most important biologically. Acidosis also increases free calcium and alkalosis decreases free calcium.
Problems associated with hypercalcemia include nausea, emesis, abdominal pain, constipation, polyuria, dehydra...
Source: PediatricEducation.org - March 25, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news
Opioids can cause endocrine dysfunction
3 out of 5 stars
The Effect of Opioid Therapy on Endocrine Function. Brennan MJ. Am J Med 2013 Mar;126:S12-S18.
Abstract
In recent months, TPR has discussed recent medical literature detailing various averse effects of chronic opioid therapy, including narcotic bowel syndrome and opioid-induced hyperalgesia, Additional adverse effects include sedation, immune suppression, and worsening sleep apnea. This well done review article provides a helpful outline of yet another complication: depressed endocrine function.
The author notes that opioids affect 2 endocrine pathways. The first pathway is the hypothalamic-pituitary-...
Source: The Poison Review - February 26, 2013 Category: Toxicology Authors: Leon Tags: Medical adrenal endocrine function gonads hypothalamus narcotics opiates opioids ovaries pituitary testes Source Type: news
Tired and listless? You may need more stress hormone
Kaye Occleston was diagnosed with a potentially fatal disorder called adrenal insufficiency, 12 years after she became ill. (Source: the Mail online | Health)
Source: the Mail online | Health - February 19, 2013 Category: Consumer Health News Source Type: news
