Autoimmune Disorders Associated With Surgical Remission of Cushing's Disease : A Cohort Study
CONCLUSION: Patients achieving surgical remission of CD have higher incidence of autoimmune disease than age- and sex-matched patients with NFPAs. Family history of autoimmune disease is a potential risk factor. Adrenal insufficiency may be a trigger.PRIMARY FUNDING SOURCE: Recordati Rare Diseases Inc.PMID:38373302 | DOI:10.7326/M23-2024 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - February 19, 2024 Category: Internal Medicine Authors: Dennis Delasi Nyanyo Masaaki Mikamoto Francesca Galbiati Ilan Remba-Shapiro Kevin Bode Sara Schoenfeld Pamela S Jones Brooke Swearingen Lisa B Nachtigall Source Type: research

Dual-release hydrocortisone improves body composition and the glucometabolic profile in patients with secondary adrenal insufficiency
ConclusionThis study suggests that switching to DR-HC leads to lower late-evening cortisol/cortisone exposure and a more favourable metabolic profile and body composition. In contrast, decreased osteocalcin with increasing sclerostin might indicate a negative impact on bones.Clinical trial registrationEudraCT201400203932 (Source: Endocrine)
Source: Endocrine - February 12, 2024 Category: Endocrinology Source Type: research

Course of COVID-19 infection in patients with congenital adrenal hyperplasia
ConclusionPatients with CAH with close follow-up do not appear to be at increased risk of acquiring COVID-19 or to have a more severe course of COVID-19 compared to the general USA population. Obesity may increase risk of acquiring COVID-19 in patients with CAH, and overall infection risk may be lower in those receiving short-acting and circadian glucocorticoid replacement therapy. Established age-appropriate guidelines for stress dosing during infectious illnesses should be used for patients with CAH and COVID-19. COVID-19 specific guidelines are not indicated. Clinical Trial Registration: ClinicalTrials.gov, identifier N...
Source: Frontiers in Endocrinology - February 9, 2024 Category: Endocrinology Source Type: research

Case report: Antiphospholipid syndrome presenting as primary adrenal insufficiency
(Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - February 7, 2024 Category: Rheumatology Authors: Akhil Pawan Goel, Atul Dhingra Tags: LETTER TO THE EDITOR Source Type: research

Glucocorticoid-induced adrenal insufficiency after therapy with intravenous methylprednisolone in patients with moderate-to-severe and active Graves ’ orbitopathy: assessment with a low-dose corticotropin test
ConclusionFor the first time, our research shows that administering IVMP in 12 weekly pulses can result in GC-induced AI. We suggest that patients should undergo careful evaluation for GC-induced AI, including LDT, after therapy with IVMP according to EUGOGO guidelines. Screening for altered adrenal reserve could prevent life-threatening complications, particularly during acute stress situations. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 4, 2024 Category: Endocrinology Source Type: research

Adrenal insufficiency in liver diseases - pathophysiology and underlying mechanisms
In conclusion, the complex pathophysiology of adrenal dysfunction in cirrhosis has not been fully elucidated yet and further research is needed in order to better understand this rather common entity in cirrhosis.PMID:38305832 | DOI:10.1007/s11154-024-09874-0 (Source: ENDOCR REV)
Source: ENDOCR REV - February 2, 2024 Category: Endocrinology Authors: Maria Kalafateli Ioanna Aggeletopoulou Christos Triantos Source Type: research

Adrenal insufficiency in liver diseases - pathophysiology and underlying mechanisms
In conclusion, the complex pathophysiology of adrenal dysfunction in cirrhosis has not been fully elucidated yet and further research is needed in order to better understand this rather common entity in cirrhosis. (Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - February 2, 2024 Category: Endocrinology Source Type: research

A retrospective study on weaning glucocorticoids and recovery of the hypothalamic-pituitary-adrenal axis
CONCLUSIONS: Patients with glucocorticoid induced AI maintained on once-daily prednisolone can recover HPA axis function when weaning. There is no apparent advantage to recover HPA axis function in converting to multiple dosing hydrocortisone.PMID:38298131 | DOI:10.1210/clinem/dgae059 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 1, 2024 Category: Endocrinology Authors: Muhammad Fahad Arshad Charlotte Elder John Newell-Price Richard Ross Miguel Debono Source Type: research

Novel agents to treat adrenal insufficiency: findings of preclinical and early clinical trials
Expert Opin Investig Drugs. 2024 Jan 29:1-12. doi: 10.1080/13543784.2024.2311207. Online ahead of print.ABSTRACTINTRODUCTION: Adrenal insufficiency currently affects over 300/million population, with higher morbidity and mortality compared to the general population. Current glucocorticoid replacement therapy is limited by a lack of reliable biomarkers to guide dosing, inter-patient variation in metabolism and narrow therapeutic window. Increased morbidity and mortality may relate to unappreciated under- or over-exposure to glucocorticoids and impaired cortisol circadian rhythm. New agents are required to emulate physiologi...
Source: Expert Opinion on Investigational Drugs - January 29, 2024 Category: Drugs & Pharmacology Authors: Andrew Peel R Louise Rushworth David J Torpy Source Type: research

Mortality in patients with adrenal insufficiency: a protocol for a systematic review and meta-analysis
Introduction Adrenal insufficiency (AI) is a rare disorder characterised by an impaired secretion of glucocorticoids from the adrenal glands. Treatment strategies for AI have developed over time with reduced glucocorticoid replacement doses and improved circadian exposure regimens, but whether this has resulted in better survival is unknown. The main purpose of this systematic review is to gather and synthesise available evidence on long-term mortality in patients with AI. The secondary aim is to study causes of death, with focus on cardiovascular and infectious diseases, in AI patients. Methods and analysis Studies publi...
Source: BMJ Open - January 29, 2024 Category: General Medicine Authors: Allosso, F., Dalakas, K., Bergthorsdottir, R., Chantzichristos, D., Hessman, E., Nwaru, B. I., Bobbio, E., Pasquali, D., Johannsson, G., Esposito, D. Tags: Open access, Diabetes and Endocrinology Source Type: research

Association of inflammatory bowel disease and autoimmune primary adrenal insufficiency
To assess the prevalence and association of inflammatory bowel disease (IBD) with autoimmune primary adrenal insufficiency (APAI). (Source: Gastroenterology)
Source: Gastroenterology - January 25, 2024 Category: Gastroenterology Authors: Salman Haider, Daryl Ramai, Saira Shah, Asad Ur Rahman, Moazzam Hussain, Iyad Al-Bustami, Praneeth Bandaru, Denzil Etienne Source Type: research

Iatrogenic adrenal insufficiency in adults
Nature Reviews Endocrinology, Published online: 25 January 2024; doi:10.1038/s41574-023-00929-xIatrogenic adrenal insufficiency (IAI) is the most common form of adrenal insufficiency in adult patients. This comprehensive Review aims to aid clinicians in identifying who is at risk of IAI, how to approach screening of at-risk populations and how to treat patients with IAI. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 25, 2024 Category: Endocrinology Authors: Julie Martin-Grace Maria Tomkins Michael W. O ’Reilly Mark Sherlock Source Type: research

Lack of NAD(P)+ transhydrogenase activity in patients with primary adrenal insufficiency due to NNT variants
CONCLUSIONS: The manifestation of PAI in NNT-mutated patients is associated with a complete lack of NNT activity. Evaluation of NNT activity can be useful to characterize disease-causing NNT variants.PMID:38261461 | DOI:10.1093/ejendo/lvae011 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - January 23, 2024 Category: Endocrinology Authors: Annelise Francisco Ayse Mine Yilmaz Goler Claudia Daniele Carvalho Navarro Asan Onder Melek Yildiz Yasemin Kendir Demirkol Betul Karademir Yilmaz Tuba Seven Menevse T ülay Güran Roger Frig ério Castilho Source Type: research

Immune checkpoint inhibitor-induced isolated adrenocorticotropic hormone deficiency: a systematic review
ConclusionIAD was predominant in elderly male patients mainly receiving anti-PD-1 or anti-PD-L1 antibodies. It was sometimes difficult to recognize IAD at first glance since non-specific symptoms were common and asymptomatic cases of IAD were also reported. Although IAD can be deadly, it usually does not affect the continued use of ICIs. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 22, 2024 Category: Endocrinology Source Type: research