N-terminally truncated A β4-x proteoforms and their relevance for Alzheimer’s pathophysiology

ConclusionsThe persistence of aggregation-prone A β4-x proteoforms likely contributes to the process of amyloid formation, self-perpetuating the amyloidogenic loop and exacerbating amyloid-mediated pathogenic pathways.

Source: Translational Neurodegeneration - June 1, 2022 Category: Neurology Source Type: research