Selection of Payloads for Antibody –Drug Conjugates Targeting Ubiquitously Expressed Tumor-Associated Antigens: a Case Study

In conclusion, SY02-DXd demonstrated superior efficacy and safety with the widest therapeutic window. Based on the efficacy and safety results, moderate cytotoxic payloads would be ideal choices for ADCs targeting ubiquitously expressed antigens.Graphical Abstract
Source: The AAPS Journal - Category: Drugs & Pharmacology Source Type: research