The Effect of Rifampicin on Darunavir, Ritonavir, and Dolutegravir Exposure within Peripheral Blood Mononuclear Cells: a Dose Escalation Study

This study showed a differential impact of enzyme and/or transporter induction on DRV/r concentrations in plasma and PBMCs, highlighting the usefulness of studying intra-PBMC pharmacokinetics with drug-drug interactions. (This study has been registered at ClinicalTrials.gov under registration no. NCT03892161.).PMID:35583344 | DOI:10.1128/aac.00136-22

Source: Antimicrobial Agents and Chemotherapy - May 18, 2022 Category: Microbiology Authors: Amedeo De Nicol ò Andrea Calcagno Ilaria Motta Elisa De Vivo Antonio D'Avolio Giovanni Di Perri Lubbe Wiesner Isma-Eel Ebrahim Gary Maartens Catherine Orrell Helen McIlleron Source Type: research