FISH patterns of ROS1, MET, and ALK with a correlation of ALK immunohistochemistry in lung cancer: a case for introducing ALK immunohistochemistry & #39;Equivocal & #39; interpretation category in the Ventana anti-ALK (D5F3) CDx assay - A tertiary cancer center experience

Conclusions: ALK/ROS1/MET gene alterations were found in 25.18% of NSCLC cases. An ALK IHC “equivocal” interpretation category should be incorporated into practice. Atypical patterns of ROS1 and genomic heterogeneity need to be evaluated further for any clinical relevance.
Source: Indian Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research