Implications For Inflammation and Host-Microbiome Interactions In Bowel Dysfunction And Pain After Spinal Cord Injury

Neurogenic bowel (NB) affects up to 60% of people with spinal cord injury (SCI) and is characterized by slow colonic transit, constipation, and chronic abdominal pain. NB rarely resolves and tends to worsen over time, making it a long-term physical and psychological challenge for people with SCI. The knowledge gap surrounding the underlying mechanisms of NB after SCI means that interventions are symptom-focused with only modest gains reported. Identifying the mechanism(s) that initiate and maintain NB after SCI is critically important to the development of evidence-based, novel therapeutic options for bowel dysfunction and pain after SCI.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: 3 Source Type: research