LIM and SH3 protein 1 (LASP1) differentiates malignant chordomas from less malignant chondrosarcomas

ConclusionLASP1 is strongly expressed in the majority of chordoma cases and shows low expression in chondrosarcoma tissue. Since LASP1  is known to function as oncogene and regulate cell proliferation in other tumor types, this study implicates a role for LASP1 in chordoma biology. Further studies are warranted to improve understanding of LASP1’s expression and functioning within chordoma, both in vitro and in vivo.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research